味觉感受器,类型2,成员14,TAS2R14 是一个人类基因组中TAS2R14基因编码的蛋白质,是苦味味觉感受器的一员[1][2][3]。
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该基因所属的味觉感受器家族是G蛋白偶联受体超家族中的一员,其蛋白主要表达在舌头和腭的上皮味觉受体细胞中。它们是组织在基因组中的基因集群,在小鼠和人类中表达在苦味位点。在功能表达研究中,TAS2R14与(-)-α-侧柏酮(苦艾酒和印防己毒素中的原发性神经毒性剂)相关[4]。该基因所在的味觉感受器基因簇位于12号染色体短臂13带[3]。
TAS2R14和其它几种苦味感受器也在人类呼吸道平滑肌细胞上表达。它们在这些细胞中的活化会导致细胞内钙离子增加,从而触发钾离子通道打开,使细胞膜超极化,平滑肌放松。因此,这些受体的活化会导致支气管扩张。[5]
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