CRADD

含有死亡结构域的蛋白质CRADD（英语：Death domain-containing protein CRADD）是人类中由CRADD基因编码的蛋白质。^[6][7][8]

CRADD
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 2O71、​2OF5、​3CRD
识别号
别名	CRADD；, MRT34, RAIDD, CASP2 and RIPK1 domain containing adaptor with death domain
外部ID	OMIM：603454 MGI：1336168 HomoloGene：2821 GeneCards：CRADD
相关疾病
阿茲海默症、​syndromic intellectual disability[1]
基因位置（人类） 染色体 12号染色体[2] 基因座 12q22 起始 93,677,375 bp[2] 终止 93,894,840 bp[2]
基因位置（小鼠） 染色体 小鼠10号染色体[3] 基因座 10 C2|10 49.26 cM 起始 95,010,608 bp[3] 终止 95,159,995 bp[3]
基因本体 分子功能 • protein-macromolecule adaptor activity • 血浆蛋白结合 • 蛋白酶结合 • death domain binding 细胞组分 • 细胞质 • 细胞核 • 细胞质基质 生物学过程 • cellular response to mechanical stimulus • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic process • extrinsic apoptotic signaling pathway via death domain receptors • 信号转导 • 细胞凋亡 • regulation of apoptotic process • positive regulation of apoptotic process • apoptotic signaling pathway Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	8738	12905
Ensembl	ENSG00000169372	ENSMUSG00000045867
UniProt	P78560 Q8IY43	O88843
mRNA​序列	NM_003805 ​NM_001320099 ​NM_001320100 ​NM_001320101 ​NM_001330126	NM_009950 ​NM_001330138 ​NM_001330141 ​NM_001330175
蛋白序列	NP_001307028 ​NP_001307029 ​NP_001307030 ​NP_001317055 ​NP_003796 NP_001307028.1	NP_001317067 ​NP_001317070 ​NP_001317104 ​NP_034080
基因位置​（UCSC）	Chr 12: 93.68 – 93.89 Mb	Chr 10: 95.01 – 95.16 Mb
PubMed​查找	[4]	[5]
维基数据
查看/编辑人类 查看/编辑小鼠

功能

该基因编码的蛋白质是含有死亡结构域（CARD/DD）的蛋白质，已被证明可诱导细胞凋亡。通过其CARD结构域（英语：CARD (domain)），该蛋白与胱天蛋白酶2/ICH1相互作用，从而将胱天蛋白酶2/ICH1募集到细胞死亡信号转导复合物中，该复合物包括肿瘤坏死因子受体1（英语：Tumor necrosis factor receptor 1）（TNFR1A）、RIPK1（英语：RIPK1）/RIP激酶和许多其他含有CARD结构域的蛋白。^[8]

相互作用

CRADD已被证明与RIPK1（英语：RIPK1）^[6][7]和胱天蛋白酶2^[6][9][10]相互作用。

参考资料

1. 與CRADD相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000169372 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000045867 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule (PDF). Nature. January 1997, 385 (6611): 86–9. Bibcode:1997Natur.385...86D. PMID 8985253. S2CID 4317538. doi:10.1038/385086a0. hdl:2027.42/62739 .
7. Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. March 1997, 57 (4): 615–9. PMID 9044836.
8. Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain. [2024-01-20]. （原始内容存档于2010-12-05）.
9. Tinel A, Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. May 2004, 304 (5672): 843–6. Bibcode:2004Sci...304..843T. PMID 15073321. S2CID 6583298. doi:10.1126/science.1095432.
10. Droin N, Beauchemin M, Solary E, Bertrand R. Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. December 2000, 60 (24): 7039–47. PMID 11156409.

外部链接

• Human CRADD genome location and CRADD gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

延伸阅读

• Lennon G, Auffray C, Polymeropoulos M, Soares MB. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics. 1996, 33 (1): 151–2. PMID 8617505. doi:10.1006/geno.1996.0177 .
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M. Generation and analysis of 280,000 human expressed sequence tags. Genome Res. 1996, 6 (9): 807–28. PMID 8889549. doi:10.1101/gr.6.9.807 .
• Chou JJ, Matsuo H, Duan H, Wagner G. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell. 1998, 94 (2): 171–80. PMID 9695946. S2CID 16499945. doi:10.1016/S0092-8674(00)81417-8 .
• Horvat S, Medrano JF. A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region. Genomics. 1998, 54 (1): 159–64. PMID 9806843. doi:10.1006/geno.1998.5540.
• Shearwin-Whyatt LM, Harvey NL, Kumar S. Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. Cell Death Differ. 2000, 7 (2): 155–65. PMID 10713730. doi:10.1038/sj.cdd.4400632 .
• Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L. Activation of the NF-kappaB pathway by caspase 8 and its homologs. Oncogene. 2000, 19 (39): 4451–60. PMID 11002417. doi:10.1038/sj.onc.1203812 .
• Droin N, Beauchemin M, Solary E, Bertrand R. Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. 2000, 60 (24): 7039–47. PMID 11156409.
• Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. 2002, 277 (16): 13430–7. PMID 11832478. doi:10.1074/jbc.M108029200 .
• Tinel A, Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. 2004, 304 (5672): 843–6. Bibcode:2004Sci...304..843T. PMID 15073321. S2CID 6583298. doi:10.1126/science.1095432.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209.
• Park HH, Wu H. Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly. J. Mol. Biol. 2006, 357 (2): 358–64. PMC 2902980 . PMID 16434054. doi:10.1016/j.jmb.2005.12.082.
• Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene. 2006, 25 (41): 5683–92. PMID 16652156. doi:10.1038/sj.onc.1209569 .
• Park HH, Wu H. Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD. Acta Crystallographica Section F. 2007, 63 (Pt 3): 229–32. PMC 2330181 . PMID 17329820. doi:10.1107/S1744309107007889.