多巴胺β羟化酶生物催化剂 / 维基百科,自由的 encyclopedia 多巴胺β羟化酶 (英语:Dopamine β-hydroxylase,简称DBH)是一种多巴胺转化为去甲肾上腺素的酶。 Dopamine is converted to norepinephrine by the enzyme dopamine β-hydroxylase. Ascorbic acid serves as a cofactor. Quick Facts 多巴胺β羟化酶, 已知的结构 ...多巴胺β羟化酶已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表4ZEL识别号别名DBH;, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase, ORTHYP1外部IDOMIM:609312 MGI:94864 HomoloGene:615 GeneCards:DBH EC number1.14.17.1相关疾病dopamine beta-hydroxylase deficiency[1]为以下药物的标靶nepicastat[2]基因位置(人类)染色体9号染色体[3]基因座9q34.2起始133,636,363 bp[3]终止133,659,329 bp[3]基因位置(小鼠)染色体小鼠2号染色体[4]基因座2 A3|2 19.29 cM起始27,055,245 bp[4]终止27,073,212 bp[4]RNA表达模式查阅更多表达数据基因本体分子功能• 金属离子结合• monooxygenase activity• oxidoreductase activity• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen• L-ascorbic acid binding• 催化活性• dopamine beta-monooxygenase activity• copper ion binding细胞组分• 细胞质• transport vesicle membrane• integral component of membrane• chromaffin granule lumen• chromaffin granule membrane• cytoplasmic vesicle• 膜• 细胞外区域• 细胞外空间• secretory granule membrane• secretory granule lumen• 细胞内膜结合细胞器• 内质网• 微管组织中心生物学过程• response to amphetamine• 化学性突触传递• homoiothermy• leukocyte mediated immunity• visual learning• fear response• behavioral response to ethanol• locomotory behavior• regulation of extrinsic apoptotic signaling pathway• regulation of cell population proliferation• positive regulation of vasoconstriction• glucose homeostasis• 母性行为• 记忆• leukocyte migration• response to pain• blood vessel remodeling• cytokine production• 联想型学习• catecholamine biosynthetic process• dopamine catabolic process• norepinephrine biosynthetic process• octopamine biosynthetic process• positive regulation of cold-induced thermogenesisSources:Amigo / QuickGO直系同源物种人类小鼠Entrez162113166EnsemblENSG00000123454ENSMUSG00000000889UniProtP09172Q64237mRNA序列NM_000787NM_138942蛋白序列NP_000778NP_620392基因位置(UCSC)Chr 9: 133.64 – 133.66 MbChr 2: 27.06 – 27.07 MbPubMed查找[5][6]维基数据查看/编辑人类查看/编辑小鼠Close 多巴胺β羟化酶是一个由四个相同亚基组成的290千道尔顿加氧酶,催化需维生素C作为辅因子[7]。
多巴胺β羟化酶 (英语:Dopamine β-hydroxylase,简称DBH)是一种多巴胺转化为去甲肾上腺素的酶。 Dopamine is converted to norepinephrine by the enzyme dopamine β-hydroxylase. Ascorbic acid serves as a cofactor. Quick Facts 多巴胺β羟化酶, 已知的结构 ...多巴胺β羟化酶已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表4ZEL识别号别名DBH;, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase, ORTHYP1外部IDOMIM:609312 MGI:94864 HomoloGene:615 GeneCards:DBH EC number1.14.17.1相关疾病dopamine beta-hydroxylase deficiency[1]为以下药物的标靶nepicastat[2]基因位置(人类)染色体9号染色体[3]基因座9q34.2起始133,636,363 bp[3]终止133,659,329 bp[3]基因位置(小鼠)染色体小鼠2号染色体[4]基因座2 A3|2 19.29 cM起始27,055,245 bp[4]终止27,073,212 bp[4]RNA表达模式查阅更多表达数据基因本体分子功能• 金属离子结合• monooxygenase activity• oxidoreductase activity• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen• L-ascorbic acid binding• 催化活性• dopamine beta-monooxygenase activity• copper ion binding细胞组分• 细胞质• transport vesicle membrane• integral component of membrane• chromaffin granule lumen• chromaffin granule membrane• cytoplasmic vesicle• 膜• 细胞外区域• 细胞外空间• secretory granule membrane• secretory granule lumen• 细胞内膜结合细胞器• 内质网• 微管组织中心生物学过程• response to amphetamine• 化学性突触传递• homoiothermy• leukocyte mediated immunity• visual learning• fear response• behavioral response to ethanol• locomotory behavior• regulation of extrinsic apoptotic signaling pathway• regulation of cell population proliferation• positive regulation of vasoconstriction• glucose homeostasis• 母性行为• 记忆• leukocyte migration• response to pain• blood vessel remodeling• cytokine production• 联想型学习• catecholamine biosynthetic process• dopamine catabolic process• norepinephrine biosynthetic process• octopamine biosynthetic process• positive regulation of cold-induced thermogenesisSources:Amigo / QuickGO直系同源物种人类小鼠Entrez162113166EnsemblENSG00000123454ENSMUSG00000000889UniProtP09172Q64237mRNA序列NM_000787NM_138942蛋白序列NP_000778NP_620392基因位置(UCSC)Chr 9: 133.64 – 133.66 MbChr 2: 27.06 – 27.07 MbPubMed查找[5][6]维基数据查看/编辑人类查看/编辑小鼠Close 多巴胺β羟化酶是一个由四个相同亚基组成的290千道尔顿加氧酶,催化需维生素C作为辅因子[7]。