丙咪嗪是一種口服三環類抗抑鬱藥,主要用於治療抑鬱。它還可以治療焦慮和恐慌症。[5][6][7]
Quick Facts 臨床資料, 商品名(英語:Drug nomenclature) ...
丙咪嗪![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Imipramine.svg/175px-Imipramine.svg.png) |
![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1b/Imipramine-3D-balls.png/183px-Imipramine-3D-balls.png) |
臨床資料 |
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商品名 | Tofranil, Tofranil-PM, others |
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其他名稱 | Melipramine; G-22355 |
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AHFS/Drugs.com | Monograph |
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MedlinePlus | a682389 |
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核准狀況 |
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懷孕分級 | |
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給藥途徑 | By mouth, intramuscular injection |
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ATC碼 | |
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法律規範狀態 |
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法律規範 |
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藥物動力學數據 |
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生物利用度 | 94–96%[2] |
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血漿蛋白結合率 | 86%[3] |
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藥物代謝 | Liver (CYP1A2, CYP2C19, CYP2D6)[3] |
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代謝產物 | Desipramine[3] |
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生物半衰期 | 20 hours[3] |
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排泄途徑 | Kidney (80%), fecal (20%)[3] |
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識別資訊 |
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3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
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CAS號 | 50-49-7 Y |
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PubChem CID | |
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IUPHAR/BPS | |
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DrugBank | |
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ChemSpider | |
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UNII | |
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KEGG | |
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ChEBI | |
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ChEMBL | |
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PDB配體ID | |
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CompTox Dashboard (EPA) | |
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ECHA InfoCard | 100.000.039 ![編輯維基數據鏈接](//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png) |
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化學資訊 |
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化學式 | C19H24N2 |
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摩爾質量 | 280.42 g·mol−1 |
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3D模型(JSmol) | |
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CN(C)CCCN1c2ccccc2CCc2ccccc21
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InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 YKey:BCGWQEUPMDMJNV-UHFFFAOYSA-N Y
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丙咪嗪的常見副作用有口乾、昏睡、頭暈、低血壓、心跳過速、尿瀦留。丙咪嗪過量可能會導致死亡。
丙咪嗪於1951年被發現,並於1957年投入臨床使用。
Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, et al. Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: increasing the power of bioavailability tests. Journal of Pharmacokinetics and Biopharmaceutics. June 1979, 7 (3): 233–248. PMID 480146. S2CID 23232584. doi:10.1007/BF01060015.
Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ. Imipramine treatment in pediatric burn patients with symptoms of acute stress disorder: a pilot study. Journal of the American Academy of Child and Adolescent Psychiatry. July 1999, 38 (7): 873–882. PMID 10405506. doi:10.1097/00004583-199907000-00018.
Robert R, Tcheung WJ, Rosenberg L, Rosenberg M, Mitchell C, Villarreal C, et al. Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: a randomized, double-blind study. Burns. November 2008, 34 (7): 919–928. PMID 18675519. doi:10.1016/j.burns.2008.04.009.