WS-12

WS-12
	IUPAC名; (1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide
識別
CAS號	68489-09-8
PubChem	11266244
ChemSpider	9441255
SMILES	C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C;
性質
化學式	C18H27NO2
摩爾質量	289.41 g·mol−1
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

WS-12，化學式C₁₈H₂₇NO₂，是一種含氮有機化合物，能作為離子通道 TRPM8的強效選擇性激動劑，與依色林相比，WS-12對TRPM8的激動劑效力略低，但其對TRPM8的選擇性卻高得多。^[1]^[2]^[3]^[4]^[5]

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參考文獻

[1]
Bödding M, Wissenbach U, Flockerzi V. Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium. December 2007, 42 (6): 618–28. PMID 17517434. doi:10.1016/j.ceca.2007.03.005.
[2]
Sherkheli MA, Vogt-Eisele AK, Bura D, Beltrán Márques LR, Gisselmann G, Hatt H. Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. Journal of Pharmacy & Pharmaceutical Sciences. 2010, 13 (2): 242–53. PMID 20816009. doi:10.18433/j3n88n .
[3]
Liu B, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE. TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain. October 2013, 154 (10): 2169–77. PMC 3778045 . PMID 23820004. doi:10.1016/j.pain.2013.06.043.
[4]
Peixoto-Neves D, Soni H, Adebiyi A. Oxidant-induced increase in norepinephrine secretion from PC12 cells is dependent on TRPM8 channel-mediated intracellular calcium elevation. Biochemical and Biophysical Research Communications. November 2018, 506 (3): 709–715. PMID 30376995. S2CID 53107273. doi:10.1016/j.bbrc.2018.10.120.
[5]
Yin Y, Le SC, Hsu AL, Borgnia MJ, Yang H, Lee SY. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science. March 2019, 363 (6430). PMC 6478609 . PMID 30733385. doi:10.1126/science.aav9334 .