視黃酸誘導孤兒G蛋白偶聯受體

視黃酸誘導孤兒G蛋白偶聯受體（英語：Retinoic Acid-Inducible orphan G-protein-coupled receptor），縮寫為RAIG，是一組四個密切相關的G蛋白偶聯受體，其表達由視黃酸誘導。^[1]^[2]^[3]^[4]

Quick Facts G蛋白偶聯受體，家族C，第5組，成員A（英語：GPRC5A）, 識別 ...

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Quick Facts G蛋白偶聯受體，家族C，第5組，成員B（英語：GPRC5B）, 識別 ...

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Quick Facts G蛋白偶聯受體，家族C，第5組，成員C（英語：GPRC5C）, 識別 ...

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Quick Facts G蛋白偶聯受體，家族C，第5組，成員D（英語：GPRC5D）, 識別 ...

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這些蛋白質的確切功能尚未確定，但它們可能提供了視黃酸影響G蛋白信號轉導級聯的機制。此外，RAIG受體與捲曲類G蛋白偶聯受體的成員相互作用，並似乎激活Wnt信號通路。^[5]

參考資料

[1]
Cheng Y, Lotan R. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J. Biol. Chem. 1998, 273 (52): 35008–15. PMID 9857033. doi:10.1074/jbc.273.52.35008 .
[2]
Bräuner-Osborne H, Krogsgaard-Larsen P. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Genomics. 2000, 65 (2): 121–8. PMID 10783259. doi:10.1006/geno.2000.6164.
[3]
Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Genomics. 2000, 67 (1): 8–18. PMID 10945465. doi:10.1006/geno.2000.6226.
[4]
Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim. Biophys. Acta. 2001, 1518 (3): 237–48. PMID 11311935. doi:10.1016/s0167-4781(01)00197-x.
[5]
Harada Y, Yokota C, Habas R, Slusarski DC, He X. Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling. Biochem. Biophys. Res. Commun. 2007, 358 (4): 968–75. PMC 2854581 . PMID 17521608. doi:10.1016/j.bbrc.2007.04.208.