ZEB1

鋅指結構E-box-結合同源框1（Zinc finger E-box-binding homeobox 1）是一個由人類基因ZEB1編碼的蛋白質^[6][7][8]。

ZEB1
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 2E19
識別號
別名	ZEB1；, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
外部ID	OMIM：189909 MGI：1344313 HomoloGene：31779 GeneCards：ZEB1
相關疾病
富克斯營養不良[1]
基因位置（人類） 染色體 10號染色體[2] 基因座 10p11.22 起始 31,318,495 bp[2] 終止 31,529,814 bp[2]
基因位置（小鼠） 染色體 小鼠18號染色體[3] 基因座 18 4.42 cM|18 A1 起始 5,591,860 bp[3] 終止 5,775,467 bp[3]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • DNA結合 • transcription corepressor activity • 轉錄共活化因子活性 • 鋅離子結合 • 轉錄因子結合 • chromatin binding • 金屬離子結合 • 血漿蛋白結合 • nucleic acid binding • DNA結合轉錄阻遏物活性，RNA聚合酶II特異性 • DNA結合轉錄因子活性 • E-box binding • DNA-binding transcription factor activity, RNA polymerase II-specific 細胞組分 • 轉錄調節複合物 • 細胞核 • 核質 • 細胞質基質 生物學過程 • pattern specification process • embryonic skeletal system morphogenesis • regulation of smooth muscle cell differentiation • animal organ development • 細胞分化 • semicircular canal morphogenesis • regulation of transcription, DNA-templated • regulation of transcription by RNA polymerase II • transcription, DNA-templated • 神經系統的發育 • regulation of transforming growth factor beta receptor signaling pathway • regulation of T cell differentiation in thymus • central nervous system development • 軟骨生成 • regulation of mesenchymal cell proliferation • embryonic camera-type eye morphogenesis • cochlea morphogenesis • 免疫反應 • embryonic morphogenesis • cellular response to amino acid stimulus • 細胞增殖 • negative regulation of epithelial cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • negative regulation of transcription, DNA-templated • positive regulation of neuron differentiation • negative regulation of transcription by RNA polymerase II • negative regulation of endothelial cell differentiation • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	6935	21417
Ensembl	ENSG00000148516	ENSMUSG00000024238
UniProt	P37275	Q64318
mRNA​序列	NM_001128128 ​NM_001174093 ​NM_001174094 ​NM_001174095 ​NM_001174096 ​NM_030751 ​NM_001323638 ​NM_001323641 ​NM_001323642 ​NM_001323643 ​NM_001323644 ​NM_001323645 ​NM_001323646 ​NM_001323647 ​NM_001323648 ​NM_001323649 ​NM_001323650 ​NM_001323651 ​NM_001323652 ​NM_001323653 ​NM_001323654 ​NM_001323655 ​NM_001323656 ​NM_001323657 ​NM_001323658 ​NM_001323659 ​NM_001323660 ​NM_001323661 ​NM_001323662 ​NM_001323663 ​NM_001323664 ​NM_001323665 ​NM_001323666 ​NM_001323671 ​NM_001323672 ​NM_001323673 ​NM_001323674 ​NM_001323675 ​NM_001323676 ​NM_001323677 ​NM_001323678	NM_011546 ​NM_001360981 ​NM_001360982
蛋白序列	NP_001121600 ​NP_001167564 ​NP_001167565 ​NP_001167566 ​NP_001167567 ​NP_001310567 ​NP_001310570 ​NP_001310571 ​NP_001310572 ​NP_001310573 ​NP_001310574 ​NP_001310575 ​NP_001310576 ​NP_001310577 ​NP_001310578 ​NP_001310579 ​NP_001310580 ​NP_001310581 ​NP_001310582 ​NP_001310583 ​NP_001310584 ​NP_001310585 ​NP_001310586 ​NP_001310587 ​NP_001310588 ​NP_001310589 ​NP_001310590 ​NP_001310591 ​NP_001310592 ​NP_001310593 ​NP_001310594 ​NP_001310595 ​NP_001310600 ​NP_001310601 ​NP_001310602 ​NP_001310603 ​NP_001310604 ​NP_001310605 ​NP_001310606 ​NP_001310607 ​NP_110378	NP_035676 ​NP_001347910 ​NP_001347911
基因位置​（UCSC）	Chr 10: 31.32 – 31.53 Mb	Chr 18: 5.59 – 5.78 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

ZEB1（以前稱為TCF8）編碼一種帶有鋅指結構域和同源框結構域的轉錄因子，結合位點為白血球介素-2基因轉錄起始位點上游100個bp處，通過負調控來抑制白介2的表達。^[9]。ZEB1和其哺乳動物中的旁系同源蛋白ZEB2都屬於同源框轉錄因子家族中的鋅指結構家族中的Zeb家族。ZEB1蛋白質有7個鋅指結構和1個同源框結構^[10]，見右側圖。

臨床意義

基因突變對基因與 後多形角膜營養最近的一項研究建議其作出貢獻的作用，在 肺癌 的侵襲和轉移的發展。^[11]

參考文獻

1. 與ZEB1相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000148516 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000024238 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. Genomics. September 1992, 14 (1): 194–6. PMID 1427828. doi:10.1016/S0888-7543(05)80307-6.
7. Identification of a zinc finger protein that inhibits IL-2 gene expression. Science. December 1991, 254 (5039): 1791–4. PMID 1840704. doi:10.1126/science.1840704.
8. Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1.
9. Identification of a zinc finger protein that inhibits IL-2 gene expression. Science. December 1991, 254 (5039): 1791–4. PMID 1840704. doi:10.1126/science.1840704.
10. Homeodomain proteins: an update. Chromosoma. July 2016, 125 (3): 497–521. PMC 4901127 . PMID 26464018. doi:10.1007/s00412-015-0543-8.
11. Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1. Laboratory Investigation; A Journal of Technical Methods and Pathology. April 2014, 94 (4): 362–70. PMID 24468793. doi:10.1038/labinvest.2013.153.

外部連結

• FactorBook ZEB1