CEBPG

CCAAT/增強子結合蛋白γ，簡稱C/EBP-γ或CEBPG是一種在人體中由CEBPG基因編碼的蛋白質。^[5][6]

CEBPG
識別號
別名	CEBPG；, GPE1BP, IG/EBP-1, CCAAT/enhancer binding protein gamma, CCAAT enhancer binding protein gamma
外部ID	OMIM：138972 MGI：104982 HomoloGene：1368 GeneCards：CEBPG
基因位置（人類） 染色體 19號染色體[1] 基因座 19q13.11 起始 33,373,685 bp[1] 終止 33,382,686 bp[1]
基因位置（小鼠） 染色體 小鼠7號染色體[2] 基因座 7|7 B2 起始 34,745,847 bp[2] 終止 34,755,998 bp[2]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • DNA結合 • protein homodimerization activity • DNA結合轉錄因子活性 • DNA-binding transcription activator activity, RNA polymerase II-specific • 轉錄因子結合 • RNA polymerase II cis-regulatory region sequence-specific DNA binding • 血漿蛋白結合 • sequence-specific DNA binding • protein heterodimerization activity • DNA-binding transcription factor activity, RNA polymerase II-specific • double-stranded DNA binding • RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending 細胞組分 • 核質 • 細胞核 生物學過程 • regulation of transcription, DNA-templated • positive regulation of DNA repair • positive regulation of DNA-binding transcription factor activity • negative regulation of DNA-binding transcription factor activity • transcription, DNA-templated • enucleate erythrocyte differentiation • 免疫反應 • mRNA metabolic process • B cell differentiation • positive regulation of DNA binding • positive regulation of transcription by RNA polymerase II • natural killer cell mediated cytotoxicity • transcription by RNA polymerase II • liver development • regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	1054	12611
Ensembl	ENSG00000153879	ENSMUSG00000056216
UniProt	P53567	P53568
mRNA​序列	NM_001806 ​NM_001252296	NM_009884
蛋白序列	NP_001239225 ​NP_001797	NP_034014
基因位置​（UCSC）	Chr 19: 33.37 – 33.38 Mb	Chr 7: 34.75 – 34.76 Mb
PubMed​查找	[3]	[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

C/EBP轉錄因子家族調節病毒和細胞CCAAT/增強子元件介導的轉錄。C/EBP蛋白包含bZIP區域，其特徵在於蛋白質的C端一半中的兩個基序：一個參與DNA結合的鹼性區域和一個參與二聚化的白氨酸拉鏈基序。 C/EBP家族由幾種相關的蛋白質組成，即C/EBP-α、C/EBP-β、C/EBP-γ和C/EBP-δ，它們形成同源二聚體並相互形成異源二聚體。CEBPG可以與Fos合作以結合PRE-I增強子元件。^[6]

參見

• CCAAT/增強子結合蛋白

參考文獻

1. GRCh38: Ensembl release 89: ENSG00000153879 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056216 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Williams SC, Cantwell CA, Johnson PF. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. Oct 1991, 5 (9): 1553–67. PMID 1884998. doi:10.1101/gad.5.9.1553 .
6. Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma. [2022-11-01]. （原始內容存檔於2009-05-11）.

閱讀

• Nishizawa M, Nagata S. cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein.. FEBS Lett. 1992, 299 (1): 36–8. PMID 1371974. S2CID 34097395. doi:10.1016/0014-5793(92)80094-W .
• Thomassin H, Hamel D, Bernier D, et al. Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma.. Nucleic Acids Res. 1992, 20 (12): 3091–8. PMC 312443 . PMID 1377818. doi:10.1093/nar/20.12.3091.
• Nishizawa M, Wakabayashi-Ito N, Nagata S. Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1.. FEBS Lett. 1991, 282 (1): 95–7. PMID 1709121. S2CID 948618. doi:10.1016/0014-5793(91)80452-9.
• Cooper C, Henderson A, Artandi S, et al. Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators.. Nucleic Acids Res. 1996, 23 (21): 4371–7. PMC 307392 . PMID 7501458. doi:10.1093/nar/23.21.4371.
• Davydov IV, Bohmann D, Krammer PH, Li-Weber M. Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.. Gene. 1995, 161 (2): 271–5. PMID 7665092. doi:10.1016/0378-1119(95)00271-7.
• Lundgren M, Larsson C, Femino A, et al. Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site.. J. Immunol. 1994, 153 (7): 2983–95. PMID 8089482.
• Martin ML, Lieberman PM, Curran T. Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.. Mol. Cell. Biol. 1996, 16 (5): 2110–8. PMC 231198 . PMID 8628277. doi:10.1128/mcb.16.5.2110.
• Gao H, Parkin S, Johnson PF, Schwartz RC. C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters.. J. Biol. Chem. 2002, 277 (41): 38827–37. PMID 12177065. doi:10.1074/jbc.M206224200 .
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
• Hattori T, Ohoka N, Inoue Y, et al. C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.. Oncogene. 2003, 22 (9): 1273–80. PMID 12618752. doi:10.1038/sj.onc.1206204 .
• Newman JR, Keating AE. Comprehensive identification of human bZIP interactions with coiled-coil arrays.. Science. 2003, 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. PMID 12805554. S2CID 36715183. doi:10.1126/science.1084648.
• Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
• Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network.. Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209.
• Mullins DN, Crawford EL, Khuder SA, et al. CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma.. BMC Cancer. 2006, 5: 141. PMC 1310620 . PMID 16255782. doi:10.1186/1471-2407-5-141.

外部連結

• 醫學主題詞表（MeSH）：CEBPG+protein,+human
• Human CEBPG genome location and CEBPG gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.