CD86

CD86
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	1I85、1NCN
識別號
別名	CD86；, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule
外部ID	OMIM：601020 MGI：101773 HomoloGene：10443 GeneCards：CD86
相關疾病
	多發性硬化症
為以下藥物的標靶
	阿巴西普
基因位置（人類）
染色體	3號染色體
終止	122,121,139 bp
基因位置（小鼠）
染色體	小鼠16號染色體
終止	36,486,443 bp
RNA表達模式
	; ; ; ;
	查閱更多表達數據
基因本體
分子功能	• coreceptor activity; • virus receptor activity; • 血漿蛋白結合; • signaling receptor binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • signaling receptor activity;
細胞組分	• integral component of membrane; • 細胞內膜結合細胞器; • 膜; • 細胞膜; • cell surface; • 外排體; • external side of plasma membrane;
生物學過程	• response to yeast; • 適應性免疫; • response to interferon-gamma; • immune system process; • cell-cell signaling; • T cell costimulation; • 老化; • myeloid dendritic cell differentiation; • cellular response to cytokine stimulus; • T cell proliferation involved in immune response; • toll-like receptor signaling pathway; • positive regulation of transcription, DNA-templated; • B cell activation; • response to lipopolysaccharide; • cellular response to metal ion; • negative regulation of T cell anergy; • defense response to virus; • 免疫反應; • positive regulation of T cell proliferation; • positive regulation of cell population proliferation; • positive regulation of T-helper 2 cell differentiation; • 病毒進入; • viral process; • toll-like receptor 3 signaling pathway; • cellular response to lipopolysaccharide; • T細胞活化; • positive regulation of activated T cell proliferation; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of protein kinase B signaling; • 信號轉導; • cell surface receptor signaling pathway; • cytokine-mediated signaling pathway; • negative regulation of T cell proliferation;
	Sources:Amigo / QuickGO
直系同源
	942
	12524
	ENSG00000114013
	ENSMUSG00000022901
	P42081
	P42082
	NM_176892; NM_001206924; NM_001206925; NM_006889; NM_175862
	NM_019388
	NP_001193853; NP_001193854; NP_008820; NP_787058; NP_795711
	NP_062261
	維基數據
檢視/編輯人類	檢視/編輯小鼠

CD86（英語：Cluster of Differentiation 86，分化群86，也稱為B7-2）是一個位於3號染色體的人類基因，屬於免疫球蛋白超家族中的B7蛋白質家族^[7]，在樹突狀細胞、朗格漢斯細胞、巨噬細胞、B細胞（包括記憶B細胞）等抗原呈遞細胞上表達^[8]。