腺苷A3受體

腺苷A₃受體(Adenosine A₃ receptor)，也稱為ADORA3，是一種腺苷受體，也表示編碼它的人類基因。

腺苷A3受體
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 1OEA、​1R7N
識別號
別名	ADORA3；, A3AR, AD026, bA552M11.5, adenosine A3 receptor
外部ID	OMIM：600445 MGI：104847 HomoloGene：550 GeneCards：ADORA3
相關疾病
肥胖症[1]
為以下藥物的標靶
腺苷、​BAY 60-6583、​Regadenoson、​CCPA、​CGS-21680、​cyclopentyladenosine、​咖啡因、​CGS 15943、​8-環戊基-1,3-二丙基黃嘌呤、​flavone、​高良姜素、​istradefylline、​尼卡地平、​瑞德南特、​rolofylline、​櫻花素、​sch-442416、​sch-58261、​茶鹼、​ZM-241385、​腺苷、​namodenoson[2]
基因位置（人類） 染色體 1號染色體[3] 基因座 1p13.2 起始 111,499,429 bp[3] 終止 111,503,633 bp[3]
基因位置（小鼠） 染色體 小鼠3號染色體[4] 基因座 3 F2.2|3 46.45 cM 起始 105,778,174 bp[4] 終止 105,816,242 bp[4]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • G protein-coupled adenosine receptor activity • G protein-coupled receptor activity • signal transducer activity 細胞組分 • integral component of membrane • 細胞膜 • 膜 • integral component of plasma membrane 生物學過程 • G protein-coupled adenosine receptor signaling pathway • inflammatory response • 信號轉導 • activation of adenylate cyclase activity • regulation of heart contraction • response to wounding • negative regulation of cell population proliferation • negative regulation of cell migration • negative regulation of NF-kappaB transcription factor activity • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	140	11542
Ensembl	ENSG00000282608	ENSMUSG00000000562
UniProt	P0DMS8	Q61618,Q3U4C5
mRNA​序列	NM_001302679 ​NM_000677 ​NM_001302678	NM_009631
蛋白序列	NP_000668 ​NP_001289607 ​NP_001289608	NP_033761
基因位置​（UCSC）	Chr 1: 111.5 – 111.5 Mb	Chr 3: 105.78 – 105.82 Mb
PubMed​查找	[5]	[6]
維基數據
檢視/編輯人類 檢視/編輯小鼠

參考資料

1. 與腺苷A3受體相關的疾病；在維基數據上查看/編輯參考.
2. 對Adenosine A3 receptor起作用的藥物；在維基數據上查看/編輯參考.
3. GRCh38: Ensembl release 89: ENSG00000282608 - Ensembl, May 2017
4. GRCm38: Ensembl release 89: ENSMUSG00000000562 - Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

延伸閱讀

• Klotz KN. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch. Pharmacol. 2001, 362 (4–5): 382–91. PMID 11111832. S2CID 12938732. doi:10.1007/s002100000315.
• Monitto CL, Levitt RC, DiSilvestre D, Holroyd KJ. Localization of the A3 adenosine receptor gene (ADORA3) to human chromosome 1p. Genomics. 1995, 26 (3): 637–8. PMID 7607699. doi:10.1016/0888-7543(95)80194-Q.
• Salvatore CA, Jacobson MA, Taylor HE, et al. Molecular cloning and characterization of the human A3 adenosine receptor. Proc. Natl. Acad. Sci. U.S.A. 1993, 90 (21): 10365–9. PMC 47775 . PMID 8234299. doi:10.1073/pnas.90.21.10365.
• Sajjadi FG, Firestein GS. cDNA cloning and sequence analysis of the human A3 adenosine receptor. Biochim. Biophys. Acta. 1993, 1179 (1): 105–7. PMID 8399349. doi:10.1016/0167-4889(93)90077-3.
• Murrison EM, Goodson SJ, Edbrooke MR, Harris CA. Cloning and characterisation of the human adenosine A3 receptor gene. FEBS Lett. 1996, 384 (3): 243–6. PMID 8617363. S2CID 3170758. doi:10.1016/0014-5793(96)00324-9.
• Bonaldo MF, Lennon G, Soares MB. Normalization and subtraction: two approaches to facilitate gene discovery. Genome Res. 1997, 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791 .
• Bouma MG, Jeunhomme TM, Boyle DL, et al. Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. J. Immunol. 1997, 158 (11): 5400–8. PMID 9164961.
• Atkinson MR, Townsend-Nicholson A, Nicholl JK, et al. Cloning, characterisation and chromosomal assignment of the human adenosine A3 receptor (ADORA3) gene. Neurosci. Res. 1998, 29 (1): 73–9. PMID 9293494. S2CID 36060683. doi:10.1016/S0168-0102(97)00073-4.
• Palmer TM, Harris CA, Coote J, Stiles GL. Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor. Mol. Pharmacol. 1997, 52 (4): 632–40. PMID 9380026. doi:10.1124/mol.52.4.632.
• Liang BT, Jacobson KA. A physiological role of the adenosine A3 receptor: Sustained cardioprotection. Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (12): 6995–9. PMC 22715 . PMID 9618527. doi:10.1073/pnas.95.12.6995.
• Dougherty C, Barucha J, Schofield PR, et al. Cardiac myocytes rendered ischemia resistant by expressing the human adenosine A1 or A3 receptor. FASEB J. 1999, 12 (15): 1785–92. PMC 5550893 . PMID 9837869. doi:10.1096/fasebj.12.15.1785.
• Murphy WJ, Eizirik E, Johnson WE, et al. Molecular phylogenetics and the origins of placental mammals. Nature. 2001, 409 (6820): 614–8. PMID 11214319. S2CID 4373847. doi:10.1038/35054550.
• Gao ZG, Chen A, Barak D, et al. Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor. J. Biol. Chem. 2002, 277 (21): 19056–63. PMC 5602557 . PMID 11891221. doi:10.1074/jbc.M110960200.
• Broussas M, Cornillet-Lefèbvre P, Potron G, Nguyên P. Adenosine inhibits tissue factor expression by LPS-stimulated human monocytes: involvement of the A3 adenosine receptor. Thromb. Haemost. 2003, 88 (1): 123–30. PMID 12152652. doi:10.1055/s-0037-1613164.
• Merighi S, Mirandola P, Milani D, et al. Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells. J. Invest. Dermatol. 2002, 119 (4): 923–33. PMID 12406340. doi:10.1046/j.1523-1747.2002.00111.x.
• Trincavelli ML, Tuscano D, Marroni M, et al. A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation. Mol. Pharmacol. 2002, 62 (6): 1373–84. PMC 4806643 . PMID 12435805. doi:10.1124/mol.62.6.1373.
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
• Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. Circ. Res. 2003, 92 (5): 485–92. PMID 12600879. doi:10.1161/01.RES.0000061572.10929.2D .
• Gao ZG, Kim SK, Gross AS, et al. Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor. Mol. Pharmacol. 2003, 63 (5): 1021–31. PMC 4367541 . PMID 12695530. doi:10.1124/mol.63.5.1021.

外部連結

• Adenosine Receptors: A₃. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始內容存檔於2020-11-30）.
• Human ADORA3 genome location and ADORA3 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.