α1-B-糖蛋白（英語：Alpha-1-B glycoprotein）是一種功能未知的血漿糖蛋白，分子量為54.3 kDa，由A1BG 基因編碼[1]，和免疫球蛋白超家族成員的可變區序列有着一定相似性。胰管腺癌患者的胰液中會出現A1BG過表達[2]。
 | 沒有或很少條目連入本條目。 (2016年12月18日) |
| Alpha-1-B glycoprotein | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 標識 | |||||||||||||
| 代號 | A1BG; A1B; ABG; GAB; HYST2477 | ||||||||||||
| 擴展標識 | 遺傳學：138670 同源基因：11167 GeneCards: A1BG Gene | ||||||||||||
| |||||||||||||
| 直系同源體 | |||||||||||||
| 物種 | 人類 | 小鼠 | |||||||||||
| Entrez | 1 | 117586 | |||||||||||
| Ensembl | ENSG00000121410 | ENSMUSG00000022347 | |||||||||||
| UniProt | P04217 | Q19LI2 | |||||||||||
| mRNA序列 | NM_130786 | NM_001081067 | |||||||||||
| 蛋白序列 | NP_570602 | NP_001074536 | |||||||||||
| 基因位置 |
Chr 19: 58.86 – 58.86 Mb |
Chr 15: 60.92 – 60.92 Mb | |||||||||||
| PubMed查詢 | [1] | [2] | |||||||||||
同源體
如下表所示，α-1-B糖蛋白在如下動物中都是保守的，很可能在所有哺乳動物中都具有一定的保守性[3]。
| 拉丁文學名 | 通用名 | 與人類分化的時間（百萬年前）[4] | NCBI蛋白質編碼 | 與人類的序列相似性 | 蛋白序列長度 | 基因名 |
|---|---|---|---|---|---|---|
| Homo sapiens[5] | 人類 | -- | NP_570602 | 100% | 495 | A1BG |
| Pan troglodytes[6] | 黑猩猩 | 6.2 | XP_001146669 | 97.0% | 501 | PREDICTED: Alpha-1B-glycoprotein isoform 4 |
| Pan Paniscus[7] | 倭黑猩猩 | 6.3 | XP_003816677 | 97.0% | 499 | A1BG |
| Gorilla gorilla gorilla [8] | 大猩猩 | 8.8 | XP_004061652 | 95.0% | 275 | PREDICTED: alpha-1B-glycoprotein |
| Pongo Abelii[9] | 蘇門達臘猩猩 | 15.7 | XP_002829953 | 95.0% | 495 | alpha-1B-glycoprotein isoform 1 |
| Macaca mulatta[10] | 普通獼猴 | 29.0 | XM_001101821 | 88.0% | 351 | hypothetical protein EGK_11172, partial |
| Callithrix jacchus[11] | 普通狨 | 42.6 | XP_002762619 | 83.0% | 500 | A1BG |
| Mus musculus [12] | 小家鼠 | 91.0 | NP_001074536 | 44.0% | 512 | alpha-1B-glycoprotein precursor |
| Felis catus[13] | 貓 | 94.2 | XP_003997399 | 62.0% | 481 | PREDICTED: alpha-1B-glycoprotein |
| Equus caballus[14] | 馬 | 97.4 | XP_001495344 | 58.0% | 568 | PREDICTED: alpha-1B-glycoprotein-like |
| Loxodonta africana [15] | 非洲象 | 104.7 | XP_003406722 | 61.0% | 520 | PREDICTED: alpha-1B-glycoprotein-like |
An initial NCBI Blast alignment of alpha-1B glycoprotein illustrates that the protein is mainly composed of three immunoglobulin domains.[17]There is a large segment of amino acids from position 297 to 400 that is not shown to be an immunoglobulin domain. However, a NCBI BLAST alignment of just the amino acids from 297-400 does illustrate that the latter sequence is indeed a fourth immunoglobulin domain.[18]Ultimately, alpha-1B glycoprotein seems to be primarily composed of four immunoglobulin domains.
參考文獻
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