2009年,Legendre AM的實驗小組對Sass and Sass生產的試驗性藥物「聚異戊烯免疫刺激劑」(英語:polyprenyl immunostimulant,簡稱PI)進行了實驗,三隻使用了PI的乾性FIP患貓均生存了超過一年時間[34]。2017年,Legendre實驗小組進行了60隻乾性FIP患貓範圍的PI療效實驗,其中52隻(87%)未能活過200天,但有4隻(7%)生存了300天以上[35]。
另外,市面亦有輝瑞公司的PRIMUCELL鼻腔疫苗,但其預防效果具有爭議。輝瑞公司在1991年取得該疫苗許可時進行的實驗規模過小,且過於久遠;其理論上起效條件也頗為苛刻,要求貓必須完全未曾接觸貓冠狀病毒,儘早斷奶,此後徹底隔離,嚴格控制環境衛生,但這些措施仍無法完全保證貓不會患上FIP,因貓冠狀病毒過於普遍。此外,該疫苗研發於20世紀70年代,彼時有關冠狀病毒的研究和了解非常有限。美國貓科執業醫師協會(英語:American Association of Feline Practitioners)以及歐洲貓科疾病顧問委員會(英語:European Advisory Board on Cat Diseases)均未建議使用該疫苗。
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