P73

p73，又称为TP73，是p53蛋白家族的成员之一，以其分子量为73kD而得名，存在多种转录变体。p73的结构和功能均与p53类似，为肿瘤抑制蛋白，能调控细胞增殖并促进细胞凋亡。过表达p73的细胞增殖会停止。

P73
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4GUQ、​1COK、​1DXS、​2KBY、​2MPS、​2WQI、​2WQJ、​2WTT、​2XWC、​3VD0、​3VD1、​3VD2、​4A63、​4G82、​4G83、​4GUO
识别号
别名	TP73；, P73, tumor protein p73, CILD47
外部ID	OMIM：601990 MGI：1336991 HomoloGene：3960 GeneCards：TP73
基因位置（人类） 染色体 1号染色体[1] 基因座 1p36.32 起始 3,652,516 bp[1] 终止 3,736,201 bp[1]
基因位置（小鼠） 染色体 小鼠4号染色体[2] 基因座 4 E2|4 83.79 cM 起始 154,140,706 bp[2] 终止 154,224,665 bp[2]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • DNA结合 • sequence-specific DNA binding • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • chromatin binding • 金属离子结合 • RNA polymerase II cis-regulatory region sequence-specific DNA binding • damaged DNA binding • 血浆蛋白结合 • 相同蛋白质结合 • protein kinase binding • p53 binding • DNA结合转录因子活性 • MDM2/MDM4 family protein binding • DNA-binding transcription factor activity, RNA polymerase II-specific 细胞组分 • 细胞质 • 高尔基体 • 细胞内膜结合细胞器 • 转录调节复合物 • 细胞连接 • 染色质 • 细胞核 • 线粒体 • 核质 • 细胞质基质 生物学过程 • negative regulation of neuron apoptotic process • positive regulation of oligodendrocyte differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • 肾的发生 • cellular response to UV • negative regulation of transcription by RNA polymerase II • protein tetramerization • transcription, DNA-templated • cellular response to DNA damage stimulus • mitotic G1 DNA damage checkpoint signaling • response to organonitrogen compound • intrinsic apoptotic signaling pathway in response to DNA damage • regulation of mitotic cell cycle • positive regulation of apoptotic process • 基因调节 • DNA错配修复 • 细胞周期 • negative regulation of cardiac muscle cell proliferation • viral process • negative regulation of JUN kinase activity • response to gamma radiation • response to X-ray • positive regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • negative regulation of cell population proliferation • 细胞凋亡 • regulation of signal transduction by p53 class mediator • transcription by RNA polymerase II • regulation of apoptotic process • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of transcription, DNA-templated • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	7161	22062
Ensembl	ENSG00000078900	ENSMUSG00000029026
UniProt	O15350	Q9JJP2
mRNA​序列	NM_001126240 ​NM_001126241 ​NM_001126242 ​NM_001204184 ​NM_001204185 ​NM_001204186 ​NM_001204187 ​NM_001204188 ​NM_001204189 ​NM_001204190 ​NM_001204191 ​NM_001204192 ​NM_005427	NM_001126330 ​NM_001126331 ​NM_011642
蛋白序列	NP_001119712 ​NP_001119713 ​NP_001119714 ​NP_001191113 ​NP_001191114 ​NP_001191115 ​NP_001191116 ​NP_001191117 ​NP_001191118 ​NP_001191119 ​NP_001191120 ​NP_001191121 ​NP_005418	NP_001119802 ​NP_001119803 ​NP_035772
基因位置​（UCSC）	Chr 1: 3.65 – 3.74 Mb	Chr 4: 154.14 – 154.22 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

参见

• p53
• p63

参考文献

1. GRCh38: Ensembl release 89: ENSG00000078900 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029026 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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• Melino, Gerry. p73, the "assistant" guardian of the genome?. Annals of the New York Academy of Sciences. 2003-12, 1010: 9–15 [2021-11-10]. ISSN 0077-8923. PMID 15033688. doi:10.1196/annals.1299.002. （原始内容存档于2021-11-10）.
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• Rossi, Mario; Sayan, A. Emre; Terrinoni, Alessandro; Melino, Gerry; Knight, Richard A. Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. Annals of the New York Academy of Sciences. 2004-12, 1028: 143–149 [2021-11-10]. ISSN 0077-8923. PMID 15650240. doi:10.1196/annals.1322.015. （原始内容存档于2021-11-10）.
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• Harms, Kelly Lynn; Chen, Xinbin. p19 ras Brings a New Twist to the Regulation of p73 by Mdm2. Science's STKE. 2006-05-30, 2006 (337) [2021-11-10]. ISSN 1525-8882. PMID 16738062. doi:10.1126/stke.3372006pe24. （原始内容存档于2022-03-11） （英语）.
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