TSFM

TSFM全称线粒体热稳定延伸因子（英语：Elongation factor Ts, mitochondrial）是由基因 TSFM 编码的蛋白质，是细菌中EF-Ts（热稳定延伸因子）的同源物^[5][6]。

TSFM
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 2CP9
识别号
别名	TSFM；, EFTS, EFTSMT, Ts translation elongation factor, mitochondrial
外部ID	OMIM：604723 MGI：1913649 HomoloGene：4184 GeneCards：TSFM
基因位置（人类） 染色体 12号染色体[1] 基因座 12q14.1 起始 57,782,761 bp[1] 终止 57,808,071 bp[1]
基因位置（小鼠） 染色体 小鼠10号染色体[2] 基因座 10|10 D3 起始 126,847,441 bp[2] 终止 126,866,709 bp[2]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • translation elongation factor activity • RNA binding • 血浆蛋白结合 细胞组分 • 线粒体基质 • 胞内 • 线粒体 • 细胞核 生物学过程 • translational elongation • regulation of DNA-templated transcription, elongation • 蛋白质生物合成 • mitochondrial translational elongation • regulation of mitochondrial translation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	10102	66399
Ensembl	ENSG00000123297	ENSMUSG00000040521
UniProt	P43897	Q9CZR8
mRNA​序列	NM_005726 ​NM_001172695 ​NM_001172696 ​NM_001172697	NM_025537
蛋白序列	NP_001166166 ​NP_001166167 ​NP_001166168 ​NP_005717	NP_079813
基因位置​（UCSC）	Chr 12: 57.78 – 57.81 Mb	Chr 10: 126.85 – 126.87 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. GRCh38: Ensembl release 89: ENSG00000123297 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040521 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xin H, Woriax V, Burkhart W, Spremulli LL. Cloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver. J Biol Chem. Aug 1995, 270 (29): 17243–9. PMID 7615523. doi:10.1074/jbc.270.29.17243 .
6. Entrez Gene: TSFM Ts translation elongation factor, mitochondrial. [2022-02-10]. （原始内容存档于2010-12-05）.

延伸阅读

• Smeitink JA, Elpeleg O, Antonicka H, et al. Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs.. Am. J. Hum. Genet. 2006, 79 (5): 869–77. PMC 1698578 . PMID 17033963. doi:10.1086/508434.
• Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA. The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1.. Hum. Mol. Genet. 2006, 15 (11): 1835–46. PMID 16632485. doi:10.1093/hmg/ddl106 .
• Maksimov VV, Arman IP, Tarantul VZ. [Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]. Genetika. 2006, 42 (2): 274–7. PMID 16583711.
• Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
• Vernon JL, Burr PC, Wiley JE, Farwell MA. Assignment of the mitochondrial translation elongation factor Ts gene (TSFM) to human chromosome 12 bands q13→q14 by in situ hybridization and with somatic cell hybrids.. Cytogenet. Cell Genet. 2000, 89 (3–4): 145–6. PMID 10965106. S2CID 201991811. doi:10.1159/000015596.
• Bonaldo MF, Lennon G, Soares MB. Normalization and subtraction: two approaches to facilitate gene discovery. Genome Res. 1997, 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791 .
• Benkowski LA, Takemoto C, Ott G, et al. Interaction of mitochondrial elongation factors Tu.Ts with aminoacyl-tRNA. Nucleic Acids Symp. Ser. 1996, (33): 163–6. PMID 8643359.

外部链接

• Template:UCSC genome browser
• Template:UCSC gene details