CD66b

CD66b（cluster of differentiation 66，分化簇66b，也称为“癌胚抗原相关细胞黏附分子8”，Carcinoembryonic antigen-related cell adhesion molecule 8，缩写CEACAM8）是一种细胞表面蛋白质，属于癌胚抗原（CEA）蛋白质家族，通过糖磷脂酰肌醇（GPI）锚定在细胞膜上，在粒细胞上高表达，可作为粒细胞的标志物，参与细胞黏附、细胞迁移和病原体识别^[3] 。

CEACAM8
已知的结构 PDB 人类UniProt搜索: PDBe RCSB PDBID列表 2DKS、​4Y88、​4YIQ、​4WTZ
识别号
别名	CEACAM8；, CD66b, CD67, CGM6, NCA-95, carcinoembryonic antigen related cell adhesion molecule 8, CEA cell adhesion molecule 8
外部ID	OMIM：615747 HomoloGene：68205 GeneCards：CEACAM8
基因位置（人类） 染色体 19号染色体[1] 基因座 19q13.2 起始 42,580,243 bp[1] 终止 42,595,055 bp[1]
基因本体 分子功能 • 血浆蛋白结合 • protein heterodimerization activity 细胞组分 • anchored component of membrane • 细胞膜 • integral component of plasma membrane • 外排体 • 膜 • 细胞外空间 • azurophil granule membrane • specific granule membrane • tertiary granule membrane • cell surface 生物学过程 • 免疫反应 • leukocyte migration • neutrophil degranulation • 细胞粘附 • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	1088	无数据
Ensembl	ENSG00000124469	无数据
UniProt	P31997	无数据
mRNA​序列	NM_001816	无数据
蛋白序列	NP_001807	无数据
基因位置​（UCSC）	Chr 19: 42.58 – 42.6 Mb	无数据
PubMed​查找	[2]	无数据
维基数据
查看/编辑人类

参考文献

1. GRCh38: Ensembl release 89: ENSG00000124469 - Ensembl, May 2017
2. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Entrez Gene: CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8.

延伸阅读

• Khan WN, Frängsmyr L, Teglund S, et al. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.. Genomics. 1992, 14 (2): 384–90. PMID 1427854. doi:10.1016/S0888-7543(05)80230-7.
• Oikawa S, Inuzuka C, Kuroki M, et al. A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains.. J. Biol. Chem. 1991, 266 (13): 7995–8001. PMID 2022629. doi:10.1016/S0021-9258(18)92930-3 .
• Berling B, Kolbinger F, Grunert F, et al. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow.. Cancer Res. 1990, 50 (20): 6534–9. PMID 2208113.
• Arakawa F, Kuroki M, Misumi Y, et al. Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family.. Biochem. Biophys. Res. Commun. 1990, 166 (3): 1063–71. PMID 2306228. doi:10.1016/0006-291X(90)90975-S.
• Eades-Perner AM, Thompson J, van der Putten H, Zimmermann W. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes.. Blood. 1998, 91 (2): 663–72. PMID 9427723. doi:10.1182/blood.V91.2.663 .
• Torsteinsdóttir I, Arvidson NG, Hällgren R, Håkansson L. Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids.. Scand. J. Immunol. 1999, 50 (4): 433–9. PMID 10520185. S2CID 5692060. doi:10.1046/j.1365-3083.1999.00602.x.
• Oikawa S, Sugiyama M, Kuroki M, et al. Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8.. Biochem. Biophys. Res. Commun. 2001, 278 (3): 564–8. PMID 11095950. doi:10.1006/bbrc.2000.3858.
• Singer BB, Scheffrahn I, Heymann R, et al. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes.. J. Immunol. 2002, 168 (10): 5139–46. PMID 11994468. doi:10.4049/jimmunol.168.10.5139 .
• Zhao L, Xu S, Peterson C, et al. Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes.. J. Immunol. Methods. 2002, 270 (1): 27–35. PMID 12379336. doi:10.1016/s0022-1759(02)00215-6.
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
• Grimwood J, Gordon LA, Olsen A, et al. The DNA sequence and biology of human chromosome 19.. Nature. 2004, 428 (6982): 529–35. Bibcode:2004Natur.428..529G. PMID 15057824. doi:10.1038/nature02399 .
• Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
• Ramachandran P, Boontheung P, Xie Y, et al. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.. J. Proteome Res. 2006, 5 (6): 1493–503. PMID 16740002. doi:10.1021/pr050492k.

外部链接

• 医学主题词表（MeSH）：CEACAM8+protein,+human
• Human CEACAM8 genome location and CEACAM8 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
• PDBe-KB （页面存档备份，存于互联网档案馆） provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8)

CD66b引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。