白细胞介素-4

白细胞介素-4（白介素-4, Interleukin-4, IL-4）是II型辅助T细胞（Th2细胞）分泌的细胞因子。白细胞介素-4的生物作用，包括刺激活化B细胞和T细胞增殖、 CD4+T细胞分化成II型辅助T细胞. 它也在调节体液免疫和适应性免疫中起关键作用。白细胞介素-4诱导B细胞抗体类别转换向IgE，上调第二型主要组织兼容性复合体的产生。这一因子是由M.霍华德、W.保罗和E. 委特塔（Vitetta）在1982共同发现的。四年后人类白细胞介素-4的核苷酸序列中被分离，证实它与一小鼠蛋白B细胞刺激因子-1（BCSF-1）类似^[4].

白细胞介素-4
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1BBN、​1BCN、​1CYL、​1HIJ、​1HIK、​1HZI、​1IAR、​1ITI、​1ITL、​1ITM、​1RCB、​2B8U、​2B8X、​2B8Y、​2B8Z、​2B90、​2B91、​2CYK、​2D48、​2INT、​3BPL、​3BPN、​3QB7、​4YDY、​5FHX
识别号
别名	IL4；, Interleukin 4, IL-4
外部ID	MGI：96556 HomoloGene：491 GeneCards：IL4
基因位置（人类） 染色体 5号染色体 基因座 5q31.1 起始 132,009,678 bp 终止 132,018,370 bp
基因位置（小鼠） 染色体 小鼠11号染色体[1] 基因座 11 B1.3|11 31.97 cM 起始 53,493,809 bp[1] 终止 53,509,496 bp[1]
基因本体 分子功能 • 白细胞介素-4受体结合 • 血浆蛋白结合 • 生长因子活性 • 细胞因子受体结合 • 细胞因子活性 细胞组分 • 细胞外区域 • 细胞外空间 生物学过程 • positive regulation of T cell differentiation • dendritic cell differentiation • 内皮细胞凋亡过程的负调控 • negative regulation of complement-dependent cytotoxicity • regulation of phosphorylation • negative regulation of apoptotic process • myeloid dendritic cell differentiation • type 2 immune response • B cell activation • positive regulation of interleukin-13 production • 免疫反应 • B cell differentiation • T-helper 2 cell cytokine production • regulation of isotype switching • negative regulation of transcription, DNA-templated • negative regulation of epithelial cell migration • regulation of signaling receptor activity • cholesterol metabolic process • positive regulation of B cell proliferation • positive regulation of T cell proliferation • T细胞激活 • positive regulation of MHC class II biosynthetic process • negative regulation of osteoclast differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription by RNA polymerase II • positive regulation of isotype switching to IgE isotypes • positive regulation of isotype switching to IgG isotypes • regulation of immune response • cytokine-mediated signaling pathway • positive regulation of gene expression • positive regulation of macroautophagy • positive regulation of tyrosine phosphorylation of STAT protein • activation of Janus kinase activity • positive regulation of receptor-mediated endocytosis • positive regulation of cold-induced thermogenesis • negative regulation of neuroinflammatory response • positive regulation of amyloid-beta clearance • neuroinflammatory response • positive regulation of cellular respiration • positive regulation of ATP biosynthetic process Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3565	16189
Ensembl	ENSG00000113520	ENSMUSG00000000869
UniProt	P05112	P07750
mRNA​序列	NM_000589.4	NM_021283
蛋白序列	NP_000580 ​NP_758858 ​NP_001341919	NP_067258
基因位置​（UCSC）	Chr 5: 132.01 – 132.02 Mb	Chr 11: 53.49 – 53.51 Mb
PubMed​查找	[2]	[3]
维基数据
查看/编辑人类 查看/编辑小鼠

参看

• T细胞
• 辅助T细胞
• STAT6

参考文献

1. GRCm38: Ensembl release 89: ENSMUSG00000000869 - Ensembl, May 2017
2. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.

外部链接

• MeSH|Interleukin+4 （页面存档备份，存于互联网档案馆）