CXCL9

CXCL9（英语：Chemokine (C-X-C motif) ligand 9）是一小分子的细胞因子属于CXC趋化因子家族，又被称作“干扰素伽玛诱导的单核细胞因子”（Monokine induced by gamma interferon, MIG）^[5] 。CXCL9是T细胞趋化因子^[5] 。干扰素伽玛诱导CXCL9的表达。人类的CXCL9与CXCL10，CXCL11的基因相邻聚集在第四染色体上^[6] 。CXCL9，CXCL10, CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用^[7][8] 。

CXCL9
识别号
别名	CXCL9；, CMK, Humig, MIG, SCYB9, crg-10, C-X-C motif chemokine ligand 9
外部ID	OMIM：601704 MGI：1352449 HomoloGene：1813 GeneCards：CXCL9
基因位置（人类） 染色体 4号染色体[1] 基因座 4q21.1 起始 76,001,275 bp[1] 终止 76,007,509 bp[1]
基因位置（小鼠） 染色体 小鼠5号染色体[2] 基因座 5 E2|5 46.51 cM 起始 92,469,206 bp[2] 终止 92,475,938 bp[2]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • 细胞因子活性 • CXCR3 chemokine receptor binding • chemokine activity • 血浆蛋白结合 细胞组分 • 细胞外区域 • external side of plasma membrane • 细胞外空间 • 胞内 生物学过程 • G protein-coupled receptor signaling pathway • chemokine-mediated signaling pathway • cell-cell signaling • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of cAMP-mediated signaling • 趋化性 • positive regulation of leukocyte chemotaxis • cellular defense response • positive regulation of myoblast fusion • response to lipopolysaccharide • regulation of cell population proliferation • positive regulation of myoblast differentiation • defense response to virus • 免疫反应 • 信号转导 • defense response • inflammatory response • T cell chemotaxis • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to bacterium • neutrophil chemotaxis • leukocyte chemotaxis • cellular response to lipopolysaccharide Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	4283	17329
Ensembl	ENSG00000138755	ENSMUSG00000029417
UniProt	Q07325	P18340
mRNA​序列	NM_002416	NM_008599
蛋白序列	NP_002407	NP_032625
基因位置​（UCSC）	Chr 4: 76 – 76.01 Mb	Chr 5: 92.47 – 92.48 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

参见

• 趋化因子
• CXCR3
• CXCL10
• CXCL11

参考文献

1. GRCh38: Ensembl release 89: ENSG00000138755 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029417 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM. Human Mig chemokine: biochemical and functional characterization. J Exp Med. 1995 Nov 1;182(5):1301-14.
6. Lee HH, Farber JM. Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster". Cytogenet Cell Genet. 1996;74(4):255-8.
7. Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
8. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

外部链接

• Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（页面存档备份，存于互联网档案馆）