CSF2RB

CSF2RB又称为CD131（cluster of differentiation 131），是以下I型细胞因子受体的共用亚基：

• GM-CSF受体
• IL-3受体
• IL-5受体^[5]

CSF2RB
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1C8P、​1EGJ、​1GH7、​2GYS、​4NKQ、​5DWU、​2NA9、​2NA8
识别号
别名	CSF2RB；, CD131, CDw131, IL3RB, IL5RB, SMDP5, colony stimulating factor 2 receptor beta common subunit, betaGMR, colony stimulating factor 2 receptor subunit beta
外部ID	OMIM：138981 MGI：1339759 HomoloGene：339 GeneCards：CSF2RB
基因位置（人类） 染色体 22号染色体[1] 基因座 22q12.3 起始 36,913,628 bp[1] 终止 36,940,439 bp[1]
基因位置（小鼠） 染色体 小鼠15号染色体[2] 基因座 15 E1|15 37.36 cM 起始 78,209,952 bp[2] 终止 78,238,047 bp[2]
基因本体 分子功能 • interleukin-3 receptor activity • interleukin-5 receptor activity • 血浆蛋白结合 • cytokine receptor activity • protein tyrosine kinase activity • signaling receptor activity 细胞组分 • integral component of membrane • 膜 • 细胞膜 • integral component of plasma membrane • granulocyte macrophage colony-stimulating factor receptor complex • 胞内 生物学过程 • respiratory gaseous exchange by respiratory system • MAPK cascade • 信号转导 • response to lipopolysaccharide • peptidyl-tyrosine phosphorylation • interleukin-5-mediated signaling pathway • cellular response to interleukin-3 • interleukin-3-mediated signaling pathway • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	1439	12983
Ensembl	ENSG00000100368	ENSMUSG00000071713
UniProt	P32927	P26955
mRNA​序列	NM_000395	NM_007780 ​NM_001358854
蛋白序列	NP_000386	NP_031806 ​NP_001345783
基因位置​（UCSC）	Chr 22: 36.91 – 36.94 Mb	Chr 15: 78.21 – 78.24 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. GRCh38: Ensembl release 89: ENSG00000100368 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071713 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Woodcock et al., Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 1994 November 1; 13(21): 5176–5185.

外部链接

• 医学主题词表（MeSH）：Cytokine+Receptor+Common+beta+Subunit