BAX

BAX
Наявні структури
PDB	Пошук ортологів: PDBe RCSB
Список кодів PDB
	4BDU, 1F16, 2G5B, 2K7W, 2LR1, 3PK1, 3PL7, 4BD2, 4BD6, 4BD7, 4BD8, 4UF2, 4ZIE, 4ZIF, 4ZIG, 4ZIH, 4ZII, 4S0O
Ідентифікатори
Символи	BAX, BCL2L4, BCL2 associated X protein, BCL2 associated X, apoptosis regulator
Зовнішні ІД	OMIM: 600040 MGI: 99702 HomoloGene: 7242 GeneCards: BAX
Онтологія гена
Молекулярна функція	• protein homodimerization activity; • channel activity; • GO:0001948, GO:0016582 protein binding; • BH3 domain binding; • chaperone binding; • protein heterodimerization activity; • identical protein binding; • lipid binding; • Hsp70 protein binding;
Клітинна компонента	• гіалоплазма; • nuclear envelope; • мембрана; • Bcl-2 family protein complex; • мітохондрія; • клітинне ядро; • mitochondrial permeability transition pore complex; • мітохондріальна мембрана; • BAX complex; • ендоплазматичний ретикулум; • екзосома; • pore complex; • integral component of membrane; • внутрішньоклітинний; • endoplasmic reticulum membrane; • цитоплазма; • мітохондріальна зовнішня мембрана; • cell periphery;
Біологічний процес	• GO:1904089 negative regulation of neuron apoptotic process; • response to ionizing radiation; • germ cell development; • positive regulation of calcium ion transport into cytosol; • glycosphingolipid metabolic process; • B cell apoptotic process; • response to salt stress; • Sertoli cell proliferation; • thymocyte apoptotic process; • T cell homeostatic proliferation; • post-embryonic development; • regulation of mitochondrial membrane permeability involved in apoptotic process; • negative regulation of protein binding; • cellular response to DNA damage stimulus; • regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; • odontogenesis of dentin-containing tooth; • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; • positive regulation of IRE1-mediated unfolded protein response; • blood vessel remodeling; • positive regulation of neuron apoptotic process; • apoptotic process involved in blood vessel morphogenesis; • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; • Сперматогенез; • apoptotic signaling pathway; • проліферація; • mitochondrion morphogenesis; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • negative regulation of cell population proliferation; • cellular response to organic substance; • B cell homeostatic proliferation; • limb morphogenesis; • release of matrix enzymes from mitochondria; • extrinsic apoptotic signaling pathway; • розвиток нирки; • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; • negative regulation of apoptotic signaling pathway; • myeloid cell homeostasis; • regulation of neuron apoptotic process; • regulation of cysteine-type endopeptidase activity involved in apoptotic process; • endoplasmic reticulum calcium ion homeostasis; • response to wounding; • intrinsic apoptotic signaling pathway by p53 class mediator; • hypothalamus development; • GO:0022415 viral process; • protein homooligomerization; • response to gamma radiation; • negative regulation of fibroblast proliferation; • positive regulation of intrinsic apoptotic signaling pathway; • response to toxic substance; • B cell negative selection; • GO:1990613 mitochondrial fusion; • neuron apoptotic process; • male gonad development; • positive regulation of B cell apoptotic process; • regulation of protein heterodimerization activity; • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; • cellular response to UV; • sex differentiation; • neuron migration; • B cell homeostasis; • positive regulation of release of sequestered calcium ion into cytosol; • positive regulation of apoptotic process involved in mammary gland involution; • нейробіологія розвитку; • spermatid differentiation; • development of secondary sexual characteristics; • positive regulation of developmental pigmentation; • retina development in camera-type eye; • response to axon injury; • positive regulation of mitochondrial membrane permeability involved in apoptotic process; • cerebral cortex development; • ovarian follicle development; • запліднення; • ectopic germ cell programmed cell death; • homeostasis of number of cells within a tissue; • positive regulation of release of cytochrome c from mitochondria; • B cell receptor apoptotic signaling pathway; • negative regulation of endoplasmic reticulum calcium ion concentration; • regulation of protein homodimerization activity; • apoptotic process involved in embryonic digit morphogenesis; • leukocyte homeostasis; • positive regulation of apoptotic DNA fragmentation; • mitochondrial fragmentation involved in apoptotic process; • positive regulation of endoplasmic reticulum unfolded protein response; • establishment or maintenance of transmembrane electrochemical gradient; • homeostasis of number of cells; • vagina development; • post-embryonic camera-type eye morphogenesis; • regulation of mammary gland epithelial cell proliferation; • retinal cell programmed cell death; • regulation of cell cycle; • regulation of mitochondrial membrane potential; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • apoptotic mitochondrial changes; • protein complex oligomerization; • regulation of nitrogen utilization; • negative regulation of peptidyl-serine phosphorylation; • positive regulation of apoptotic process; • positive regulation of protein oligomerization; • extrinsic apoptotic signaling pathway via death domain receptors; • release of cytochrome c from mitochondria; • GO:0097285 апоптоз; • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • intrinsic apoptotic signaling pathway; • regulation of apoptotic process; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • intrinsic apoptotic signaling pathway in response to DNA damage; • extrinsic apoptotic signaling pathway in absence of ligand; • transcription initiation from RNA polymerase II promoter; • Unfolded Protein Response; • negative regulation of mitochondrial membrane potential;
	Джерела:Amigo / QuickGO
Шаблон експресії
	; ;
	Більше даних
Ортологи
	581
	12028
	ENSG00000087088
	ENSMUSG00000003873
	Q07812; Q5ZPJ0
	Q07813
NM_001291428; NM_001291429; NM_001291430; NM_001291431; NM_004324;
	NM_138761; NM_138762; NM_138763; NM_138764
	NM_007527
NP_001278357; NP_001278358; NP_001278359; NP_001278360; NP_004315;
	NP_620116; NP_620118; NP_620119; NP_001278358.1
	NP_031553
	Вікідані
Див./Ред. для людей	Див./Ред. для мишей

BAX (англ. BCL2 associated X, apoptosis regulator) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 19-ї хромосоми.^[3] Довжина поліпептидного ланцюга білка становить 192 амінокислот, а молекулярна маса — 21 184^[4].

Послідовність амінокислот

10	20	30	40	50
MDGSGEQPRG	GGPTSSEQIM	KTGALLLQGF	IQDRAGRMGG	EAPELALDPV
PQDASTKKLS	ECLKRIGDEL	DSNMELQRMI	AAVDTDSPRE	VFFRVAADMF
SDGNFNWGRV	VALFYFASKL	VLKALCTKVP	ELIRTIMGWT	LDFLRERLLG
WIQDQGGWDG	LLSYFGTPTW	QTVTIFVAGV	LTASLTIWKK	MG

A: Аланін

C: Цистеїн

D: Аспарагінова кислота

E: Глутамінова кислота

F: Фенілаланін

G: Гліцин

I: Ізолейцин

K: Лізин

L: Лейцин

M: Метіонін

N: Аспарагін

P: Пролін

Q: Глутамін

R: Аргінін

S: Серин

T: Треонін

V: Валін

W: Триптофан

Y: Тирозин

Коротка інформація Наявні структури, PDB ...

Закрити

Задіяний у таких біологічних процесах, як апоптоз, взаємодія хазяїн-вірус, ацетилювання, альтернативний сплайсинг. Локалізований у цитоплазмі, мембрані, мітохондрії.

[3]

[4]

[1]

[2]

BAX

Література

Примітки

Див. також

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Література

Примітки

Див. також

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