Ubikvitin je protein koji je kod čoveka kodiran genom.[1][2][3]
Кратке чињенице Dostupne strukture, Identifikatori ...
Ubikvitin C |
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1aar, 1cmx, 1d3z, 1f9j, 1fxt, 1g6j, 1gjz, 1nbf, 1ogw, 1otr, 1p3q, 1q0w, 1q5w, 1s1q, 1sif, 1tbe, 1ubi, 1ubq, 1ud7, 1uzx, 1v80, 1v81, 1wr1, 1wr6, 1wrd, 1xd3, 1xqq, 1yd8, 1yiw, 1yj1, 1yx5, 1yx6, 1zgu, 2ayo, 2bgf, 2c7m, 2c7n, 2d3g, 2den, 2dx5, 2fcm, 2fcn, 2fcq, 2fcs, 2fid, 2fif, 2fuh, 2g3q, 2g45, 2gbj, 2gbk, 2gbm, 2gbn, 2gbr, 2gmi, 2hd5, 2hth, 2ibi, 2j7q, 2nr2, 2o6v, 2oob |
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Simboli |
UBC; HMG20 |
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Vanjski ID |
OMIM: 191340 MGI: 98889 HomoloGene: 39626 GeneCards: UBC Gene |
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podaci |
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Vrsta |
Čovek |
Miš |
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Entrez |
7316 |
22190 |
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Ensembl |
ENSG00000150991 |
ENSMUSG00000008348 |
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UniProt |
P0CG48 |
Q3TH47 |
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RefSeq (mRNA) |
XM_001132949 |
XM_001001910 |
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RefSeq (protein) |
XP_001132949 |
XP_001001910 |
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Lokacija (UCSC) |
Chr 12: 123.96 - 123.97 Mb |
Chr 5: 125.68 - 125.68 Mb |
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PubMed pretraga |
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Затвори
Za ubikvitin C je pokazano da interaguje sa ,[4][5] ,[4][5] Parkin (ligazom),[6][7] kinazom 1,[8] ,[9][10][11][12][13] ,[14] ,[15] ,[16] ,[17][18] ,[19] ,[20][21][22] receptorom epidermalnog faktora rasta,[23][24][25] ,[26] Basigin,[27] ,[9][12][28][29] ,[30][31] ,[9][13][32][33][34] ,[35][36][37] Kapa opioidnim receptorom,[38] ,[39] ,[33][40][41] tiroidnim hormonskim receptorom alfa,[14] transkriptnim faktorom,[42] ,[43][44] ,[39] ,[14] [45][46][47] i .[23][35][36][37][48][49][50][51]
Marinovic AC, Zheng B, Mitch WE, Price SR (2002). „Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1”. J Biol Chem. 277 (19): 16673—81. PMID 11872750. doi:10.1074/jbc.M200501200.
Boulkroun, Sheerazed; Ruffieux-Daidié Dorothée; . (2008). „Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3”. Am. J. Physiol. Renal Physiol. United States. 295 (4): F889—900. ISSN 0363-6127. PMID 18632802. doi:10.1152/ajprenal.00001.2008.
Kawahara, Kohichi; Makoto, Hashimoto; . (2008). „alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease”. J. Biol. Chem. United States. 283 (11): 6979—87. ISSN 0021-9258. PMID 18195004. doi:10.1074/jbc.M710418200.
Panasyuk, Ganna; Ivan, Nemazanyy; . (2008). „Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1”. Biochem. Biophys. Res. Commun. United States. 369 (2): 339—43. PMID 18279656. doi:10.1016/j.bbrc.2008.02.016.
Newton, Kim; Matsumoto Marissa L; . (2008). „Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies”. Cell. United States. 134 (4): 668—78. PMID 18724939. doi:10.1016/j.cell.2008.07.039.
Tan, Fengwei; Lifang, Lu; . (2008). „Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells”. Proteomics. Germany. 8 (14): 2885—96. PMID 18655026. doi:10.1002/pmic.200700887.
Stolfi, Carmine; Daniele, Fina; . (2008). „Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase”. Carcinogenesis. England. 29 (6): 1258—66. PMID 18495657. doi:10.1093/carcin/bgn122.
Park, Young-Kwon; Ahn Dae-Ro; . (2008). „Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation”. Mol. Pharmacol. United States. 74 (1): 236—45. PMID 18426857. doi:10.1124/mol.108.045278.
Sehat, Bita; Sandra, Andersson; . (2008). „Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis”. Cancer Res. United States. 68 (14): 5669—77. PMID 18632619. doi:10.1158/0008-5472.CAN-07-6364.
Zhou, Fangfang; Long, Zhang; . (2008). „The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation”. J. Biol. Chem. United States. 283 (21): 14506—15. ISSN 0021-9258. PMID 18367454. doi:10.1074/jbc.M706136200.
Wang, Wen-Juan; Li Qing-Quan; . (2008). „Interaction between CD147 and P-glycoprotein and their regulation by ubiquitination in breast cancer cells”. Chemotherapy. Switzerland. 54 (4): 291—301. PMID 18689982. doi:10.1159/000151225.
Varfolomeev, Eugene; Tatiana, Goncharov; . (2008). „c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation”. J. Biol. Chem. United States. 283 (36): 24295—9. ISSN 0021-9258. PMID 18621737. doi:10.1074/jbc.C800128200.
Bertrand, Mathieu J M; Snezana, Milutinovic; . (2008). „cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination”. Mol. Cell. United States. 30 (6): 689—700. PMID 18570872. doi:10.1016/j.molcel.2008.05.014.
Ivanchuk, Stacey M.; Soma, Mondal; Rutka James T (2008). „p14ARF interacts with DAXX: effects on HDM2 and p53”. Cell Cycle. United States. 7 (12): 1836—50. PMID 18583933. doi:10.4161/cc.7.12.6025.
Yang, Wensheng; Dicker David T; . (2008). „CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2”. Cell Cycle. United States. 7 (5): 670—82. PMID 18382127. doi:10.4161/cc.7.5.5701.
Li, Jian-Guo; Haines Dale S; Liu-Chen Lee-Yuan (2008). „Agonist-promoted Lys63-linked polyubiquitination of the human kappa-opioid receptor is involved in receptor down-regulation”. Mol. Pharmacol. United States. 73 (4): 1319—30. PMID 18212250. doi:10.1124/mol.107.042846.
Al-Hakim, Abdallah K.; Anna, Zagorska; . (2008). „Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains”. Biochem. J. England. 411 (2): 249—60. PMID 18254724. doi:10.1042/BJ20080067.
Didelot, C; D, Lanneau; . (2008). „Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation”. Cell Death Differ. England. 15 (5): 859—66. ISSN 1350-9047. PMID 18239673. doi:10.1038/cdd.2008.5.
Wang, Yi-Ting; Chuang Jian-Ying; . (2008). „Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process”. J. Mol. Biol. England. 380 (5): 869—85. PMID 18572193. doi:10.1016/j.jmb.2008.05.043.
Carpentier, Isabelle; Beatrice, Coornaert; Rudi, Beyaert (2008). „Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation”. Biochem. Biophys. Res. Commun. United States. 374 (4): 752—7. PMID 18671942. doi:10.1016/j.bbrc.2008.07.103.
Lee, Yeon Sook; Han Jung Min; . (2008). „AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2”. Biochem. Biophys. Res. Commun. United States. 371 (3): 395—400. PMID 18448069. doi:10.1016/j.bbrc.2008.04.099.
Dohmesen, Christoph; Max, Koeppel; Matthias, Dobbelstein (2008). „Specific inhibition of Mdm2-mediated neddylation by Tip60”. Cell Cycle. United States. 7 (2): 222—31. PMID 18264029. doi:10.4161/cc.7.2.5185.
- Mazzé FM, Degrève L (2006). „The role of viral and cellular proteins in the budding of human immunodeficiency virus.”. Acta Virol. 50 (2): 75—85. PMID 16808324.
- H, Kanayama; K, Tanaka; M, Aki; . (1992). „Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells.”. Cancer Res. 51 (24): 6677—85. PMID 1660345.
- Baker RT, Board PG (1989). „Unequal crossover generates variation in ubiquitin coding unit number at the human UbC polyubiquitin locus.”. Am. J. Hum. Genet. 44 (4): 534—42. PMC 1715567 . PMID 2564731.
- Einspanier R, Sharma HS, Scheit KH (1987). „Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in human ovarian granulosa cells.”. Biochem. Biophys. Res. Commun. 147 (2): 581—7. PMID 2820408. doi:10.1016/0006-291X(87)90970-3.
- O, Wiborg; MS, Pedersen; A, Wind; . (1985). „The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.”. EMBO J. 4 (3): 755—9. PMC 554252 . PMID 2988935.
- B, Andersson; MA, Wentland; JY, Ricafrente; . (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138.
- M, Nenoi; K, Mita; S, Ichimura; . (1996). „Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells.”. Gene. 175 (1-2): 179—85. PMID 8917096. doi:10.1016/0378-1119(96)00145-X.
- W, Yu; B, Andersson; KC, Worley; . (1997). „Large-scale concatenation cDNA sequencing.”. Genome Res. 7 (4): 353—8. PMC 139146 . PMID 9110174.
- Nenoi M, Mita K, Ichimura S, Kawano A (1998). „Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus.”. Genetics. 148 (2): 867—76. PMC 1459823 . PMID 9504932.
- DE, Ott; LV, Coren; TD, Copeland; . (1998). „Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus.”. J. Virol. 72 (4): 2962—8. PMC 109742 . PMID 9525617.
- NS, Kim; T, Yamaguchi; S, Sekine; . (1998). „Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product.”. J. Biochem. 124 (1): 35—9. PMID 9644242.
- U, Schubert; DE, Ott; EN, Chertova; . (2001). „Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.”. Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13057—62. PMC 27177 . PMID 11087859. doi:10.1073/pnas.97.24.13057.
- B, Strack; A, Calistri; MA, Accola; . (2001). „A role for ubiquitin ligase recruitment in retrovirus release.”. Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13063—8. PMC 27178 . PMID 11087860. doi:10.1073/pnas.97.24.13063.
- DE, Ott; LV, Coren; EN, Chertova; . (2001). „Ubiquitination of HIV-1 and MuLV Gag.”. Virology. 278 (1): 111—21. PMID 11112487. doi:10.1006/viro.2000.0648.
- Strack B, Calistri A, Göttlinger HG (2002). „Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis.”. J. Virol. 76 (11): 5472—9. PMC 137019 . PMID 11991975. doi:10.1128/JVI.76.11.5472-5479.2002.
- L, Huang; L, Feng; L, Yang; . (2003). „Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.”. Mol. Biol. Rep. 29 (3): 317—23. PMID 12463424. doi:10.1023/A:1020409217215.
- RL, Strausberg; EA, Feingold; LH, Grouse; . (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- DE, Ott; LV, Coren; RC, Sowder; . (2003). „Retroviruses have differing requirements for proteasome function in the budding process.”. J. Virol. 77 (6): 3384—93. PMC 149504 . PMID 12610113. doi:10.1128/JVI.77.6.3384-3393.2003.
- PC, Evans; TS, Smith; MJ, Lai; . (2003). „A novel type of deubiquitinating enzyme.”. J. Biol. Chem. 278 (25): 23180—6. PMID 12682062. doi:10.1074/jbc.M301863200.