Kalpastatin je protein koji je kod ljudi kodiran CAST genom.[4][5][6][7]
Кратке чињенице CAST, Identifikatori ...
Затвори
Protein kodiran ovim genom je endogeni inhibitor kalpaina (kalcijum-zavisne cisteinske proteaze). On se sastoji od N-terminalnog domena L i četiri ponavljajuća kalpain-inhibitorna domena (domeni 1-4). Ovaj protein učestvuje u proteolizi amiloidnog prekurzornog proteina. Kalpain/kalpastatinski sistem učestvuje u brojnim membranskim fuzionim procesima, kao što su neuralno vezikularna egzocitoza i agregacija trombocita i crvenih krvnih zrnaca. Smatra se da ovaj protein takođe utiče na nivoe izražavanja gena koji kodiraju strukturne i regulatorne proteine. Poznato je nekoliko alternativno splajsovanih transkriptnih varijanti ovog gena, mada oni nisu u potpunosti ispitani.[7]
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