DDR2 (gen)

, ili (klaster diferencijacije ), je ljudski gen^[1], koji je član broj 2 familije diskoidin domen receptora.

Diskoidin domen receptor familija, izoforma 2
Identifikatori
Simboli	DDR2; MIG20a; NTRKR3; TKT; TYRO10
Vanjski ID	OMIM: 191311 MGI: 1345277 HomoloGene: 68505 GeneCards: DDR2 Gene
Ontologija gena Molekularna funkcija • nukleotidno vezivanje • aktivnost protein-tirozin kinaze • aktivnost trasmembranskog protein tirozin kinaza receptora • receptorska aktivnost • vezivanje • aktivnost transferaze Celularna komponenta • integralno sa membranom plazme • membrana Biološki proces • fosforilacija proteinskih aminokiselina • ćelijska adhezija • transdukcija signala • transmebranski receptor protein tirozin kinaza signalni put • pozitivna regulacija ćelijske proliferacije
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	4921	18214
Ensembl	ENSG00000162733	ENSMUSG00000026674
UniProt	Q16832	Q62371
RefSeq (mRNA)	NM_001014796	NM_022563
RefSeq (protein)	NP_001014796	NP_072075
Lokacija (UCSC)	Chr 1: 160.87 - 161.02 Mb	Chr 1: 171.81 - 171.95 Mb
PubMed pretraga

Receptor tirozin kinaze () igraju ključnu ulogu u komunikaciji ćelija sa njihovim mikro okruženjem. Ti molekuli su vezani za regulaciju ćelijskog rasta, diferencijacije i metabolizma. U više slučajeva biohemijski mehanizam kojim sprovodi signal kroz membranu je pokazan da se sastoji od ligand indukovane oligomerizacije receptora, i naknadne intracelularna fosforilacije. Ova autofosforilacija dovodi do naknadne fosforilacije citosolnih proteina, kao i do asocijacije sa drugim molekulima koji su vezani za pleiotropske efekte transdukcije signala. proteini imaju trojnu strukturu koja se sastoji od ekstracelularnog, transmembranskog, i citoplazmatičnog regiona. Ovaj gen kodira pripadnika nove RTK podklase sa različitim ekstracelularnim regionom koji okružuje domen sličan faktoru . Alternativno spajanje (engl. ) ovog gena na 5' UTR dovodi do nekoliko transkript varijanti.^[1]

Interakcije

Demonstrirano je da ima protein-protein interakciju sa .^[2]

Reference

1. „Entrez Gene: DDR2 discoidin domain receptor family, member 2”.
2. Ikeda, Kazuo; Wang Li-Hsien; Torres Richard; Zhao Hong; Olaso Elvira; Eng Francis J; Labrador Pablo; Klein Rudiger; Lovett David; Yancopoulos George D; Friedman Scott L; Lin Hsin Chieh (2002). „Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen”. J. Biol. Chem. United States. 277 (21): 19206—12. ISSN 0021-9258. PMID 11884411. doi:10.1074/jbc.M201078200.

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