Mizoprostol

Mizoprostol
(IUPAC) ime
	Metil 7-((1R,2R,3R)-3-hidroksi-2-((S,E)-4-hidroksi-4-metilokt-1-enil)-5-oksociklopentil)heptanoat
Klinički podaci
Robne marke	Citotek
AHFS/Drugs.com	Monografija
MedlinePlus	a689009
Identifikatori
CAS broj	59122-46-2
ATC kod	A02BB01
PubChem	5282381
DrugBank	DB00929
ChemSpider	4445541
UNII	0E43V0BB57
KEGG	D00419
ChEMBL	CHEMBL606
Hemijski podaci
Formula	C22H38O5
Mol. masa	382,534 g/mol
SMILES	eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost	ektenzivno se apsorbuje
Vezivanje za proteine plazme	85%
Metabolizam	deesterifikuje se do mizoprostolne kiseline
Poluvreme eliminacije	20–40 minuta
Izlučivanje	Renalno:80%; Fekalno:15%
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno, Vaginalno, podjezično

Mizoprostol je lek koji se koristi za sprečavanje čireva na dvanaestopalačnom crevu uzrokovanih nesteroidnim antiinflamatornim lekovima (NSAID), za tretiranje neuspešnog pobačaja, za indukovanje porođaja, i kao abortifacijent. Mizoprostol je u prodaji pod imenima Citotek, i više generičkih formulacija.^[6]^[7]

Kratke činjenice (IUPAC) ime, Klinički podaci ...

Zatvori

Farmakološki, mizoprostol je sintetički prostaglandin E₁ (PGE₁) analog.

[1]
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
[2]
Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
[3]
Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
[4]
Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
[5]
Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
[6]
Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
[7]
Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.

Misoprostol.org an independent website containing dosage guidelines and advice on misoprostol use.
The Mechanism of Action and Pharmacology of Mifepristone, Misoprostol, and Methotrexate Arhivirano 2016-07-25 na Wayback Machine-u

[1] [1]
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] [2]
Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] [3]
Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] [4]
Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] [5]
Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Goodman_Gilman-6] [6]
Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.

[PDR-7] [7]
Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.

[6]

[7]

[1]

[2]

[3]

[4]

[5]

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Mizoprostol

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Reference

Spoljašnje veze

(IUPAC) ime

Metil 7-((1R,2R,3R)-3-hidroksi-2-((S,E)-4-hidroksi-4-metilokt-1-enil)-5-oksociklopentil)heptanoat
Klinički podaci
Robne marke	Citotek
AHFS/Drugs.com	Monografija
MedlinePlus	a689009
Identifikatori
CAS broj	59122-46-2
ATC kod	A02BB01
PubChem^[1]^[2]	5282381
DrugBank	DB00929
ChemSpider^[3]	4445541
UNII	0E43V0BB57^Y
KEGG^[4]	D00419^Y
ChEMBL^[5]	CHEMBL606^Y
Hemijski podaci
Formula	C₂₂H₃₈O₅
Mol. masa	382,534 g/mol
SMILES	eMolekuli & PubHem

Farmakokinetički podaci
Bioraspoloživost	ektenzivno se apsorbuje
Vezivanje za proteine plazme	85%
Metabolizam	deesterifikuje se do mizoprostolne kiseline
Poluvreme eliminacije	20–40 minuta
Izlučivanje	Renalno:80% Fekalno:15%
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno, Vaginalno, podjezično