Gonadotropin

Gonadotropini (glikoproteinski hormoni) su proteinski hormoni koje izlučuju gonodotrpne ćelije anteriorne hipofize kičmenjaka.^[1][2][3] Ova familija proteina obuhvata sisarske hormone: folikulostimulišući hormon (FSH), luteinizirajući hormon (LH), posteljične horionske gonadotropine hCG i eCG^[4] i horionski gonadotropin (CG), kao i bar dve forme ribljih gonadotropina. Ovi hormoni su centralni u kompleksnom endokrinom sistemu koji reguliše normalni rast, seksualno razviće, i reproduktivnu funkciju.^[5] LH i FSH hormone izlučuje anteriorna hipofiza, dok se hCG i eCG izlučuju iz posteljice.^[6]

Glikoproteinski hormon

Identifikatori
Simbol	Hormone_6
Pfam	PF00236
InterPro	IPR000476
PROSITE	PDOC00623
SCOP	1hcn
Superfamilija	1hcn
OPM protein	1fl7
Dostupne PDB strukture: Pfam structures PDB RCSB PDB; PDBe PDBsum strukturni pregled

Gonadotropin se ponekad skaćeno obeležava sa Gn.

Reference

1. Parhar, Ishwar S. (2002). Gonadotropin-releasing Hormone: Molecules and Receptors. Amsterdam: Elsevier. ISBN 0-444-50979-8.
2. Pierce JG, Parsons TF (1981). „Glycoprotein hormones: structure and function”. Annu. Rev. Biochem. 50: 465–495. DOI:10.1146/annurev.bi.50.070181.002341. PMID 6267989.
3. Stockell Hartree A, Renwick AG (1992). „Molecular structures of glycoprotein hormones and functions of their carbohydrate components”. Biochem. J. 287 (Pt 3): 665–679. PMC 1133060. PMID 1445230.
4. Goodwin RG, Moncman CL, Rottman FM, Nilson JH (1983). „Characterization and nucleotide sequence of the gene for the common alpha subunit of the bovine pituitary glycoprotein hormones”. Nucleic Acids Res. 11 (19): 6873–6882. DOI:10.1093/nar/11.19.6873. PMC 326420. PMID 6314263.
5. Godine JE, Chin WW, Habener JF (1982). „alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs”. J. Biol. Chem. 257 (14): 8368–8371. PMID 6177696.
6. Golos TG, Durning M, Fisher JM (1991). „Molecular cloning of the rhesus glycoprotein hormone alpha-subunit gene”. DNA Cell Biol. 10 (5): 367–380. DOI:10.1089/dna.1991.10.367. PMID 1713773.

Literatura

• Parhar, Ishwar S. (2002). Gonadotropin-releasing Hormone: Molecules and Receptors. Amsterdam: Elsevier. ISBN 0-444-50979-8.

Vanjske veze

• MeSH Gonadotropins
• 10th International Symposium on GnRH