Bombezin

Bombezin je peptid sa 14-aminokiselina^[3], koji je originalno izolovan iz kože žabe. On ima dva poznata homologa kod sisara koji se nazivaju neuromedin B i peptid oslobađanja gastrina.

Bombezin
Drugi nazivi	Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Identifikacija
CAS registarski broj	31362-50-2
PubChem[1][2]	16133891
IUPHAR ligand	616
Svojstva
Molekulska formula	C71H110N24O18S
Molarna masa	1619.85
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
Infobox references

Bombezin stimuliše oslobađanje gastrina i G ćelija. On aktivira tri različita G protein spregnuta receptora, koji su poznati kao BBR1 2 & 3.^[4] On takođe aktivira te receptore u mozgu. Zajedno sa holecistokininom, on je drugi najveći izvor negativnog povratnog signala koji zaustavlja traženje hrane.^[5]

Bombezin je takođe marker tumora za rak malih ćelija pluća, gastričnog karcinoma, i neuroblastoma.^[6]

Povezano

• Neuromedin B
• Neuromedin U

Reference

1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
3. Gonzalez N, Moody TW, Igarashi H, Ito T, Jensen RT (February 2008). „Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states”. Current Opinion in Endocrinology, Diabetes, and Obesity 15 (1): 58–64. DOI:10.1097/MED.0b013e3282f3709b. PMC 2631407. PMID 18185064.
4. Weber HC (February 2009). „Regulation and signaling of human bombezin receptors and their biological effects”. Current Opinion in Endocrinology, Diabetes, and Obesity 16 (1): 66–71. PMID 19115523.
5. Yamada K, Wada E, Wada K (November 2000). „Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice”. Annals of Medicine 32 (8): 519–29. PMID 11127929.
6. Ohlsson B, Fredäng N, Axelson J (December 1999). „The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines”. Scandinavian Journal of Gastroenterology 34 (12): 1224–9. PMID 10636070.

Spoljašnje veze

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