Gastrin

Gastrin je proteinski hormon koji sintetišu i sekretuju G ćelije (gastrinske ćelije) želuca. Difuznog je dejstva, indukuje sekreciju želudačne kiseline i stimuliše pokrete želuca. NJegovo postojanje je privi predložio 1905. Britanski fiziolog Džon Sidni Edkins,^[1][2]. Gastrin su izolovali 1964. Gregori i Trejsi u Liverpulu.^[3]

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Gastrin
Identifikatori
Simboli	GAST; GAS
Vanjski ID	OMIM: 137250 MGI: 104768 HomoloGene: 628 GeneCards: GAST Gene
Ontologija gena Molekulska funkcija • aktivnost hormona Ćelijska komponenta • ekstracelularni region • rastvorna frakcija Biološki proces • kontrakcija glatkih mišića • prenos signala
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2520	14459
Ensembl	ENSG00000184502	ENSMUSG00000017165
UniProt	P01350	Q6GSF5
Ref. Sekv. (iRNK)	NM_000805	NM_010257
Ref. Sekv. (protein)	NP_000796	NP_034387
Lokacija (UCSC)	Chr 17: 37.12 - 37.13 Mb	Chr 11: 100.15 - 100.15 Mb
PubMed pretraga

Reference

1. Edkins JS (1906-03-13). „The chemical mechanism of gastric secretion”. J. Physiol. (Lond.) 34 (1-2): 133–44. PMC 1465807. PMID 16992839.
2. Modlin IM, Kidd M, Marks IN, Tang LH (1997). „The pivotal role of John S. Edkins in the discovery of gastrin”. World J Surg 21 (2): 226–34. DOI:10.1007/s002689900221. PMID 8995084.
3. Gregory RA, Tracy HJ (1964). „The constitution and properties of two gastrins extracted from hog antral mucosa”. Gut 5: 103–14. DOI:10.1136/gut.5.2.103. PMC 1552180. PMID 14159395.

Literatura

• Rozengurt E, Walsh JH (2001). „Gastrin, CCK, signaling, and cancer”. Annu. Rev. Physiol. 63: 49–76. DOI:10.1146/annurev.physiol.63.1.49. PMID 11181948.
• Dockray GJ (2005). „Clinical endocrinology and metabolism. Gastrin”. Best Pract. Res. Clin. Endocrinol. Metab. 18 (4): 555–68. DOI:10.1016/j.beem.2004.07.003. PMID 15533775.
• Anlauf M, Garbrecht N, Henopp T, et al. (2006). „Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features”. World J. Gastroenterol. 12 (34): 5440–6. PMID 17006979.
• Polosatov MV, Klimov PK, Masevich CG, et al. (1979). „Interaction of synthetic human big gastrin with blood proteins of man and animals”. Acta hepato-gastroenterologica 26 (2): 154–9. PMID 463490.
• Fritsch WP, Hausamen TU, Scholten T (1977). „[Gastrointestinal hormones. I. Hormones of the gastrin group]”. Zeitschrift für Gastroenterologie 15 (4): 264–76. PMID 871064.
• Higashimoto Y, Himeno S, Shinomura Y, et al. (1989). „Purification and structural determination of urinary NH2-terminal big gastrin fragments”. Biochem. Biophys. Res. Commun. 160 (3): 1364–70. DOI:10.1016/S0006-291X(89)80154-8. PMID 2730647.
• Pauwels S, Najdovski T, Dimaline R, et al. (1989). „Degradation of human gastrin and CCK by endopeptidase 24.11: differential behaviour of the sulphated and unsulphated peptides”. Biochim. Biophys. Acta 996 (1-2): 82–8. PMID 2736261.
• Lund T, Geurts van Kessel AH, Haun S, Dixon JE (1986). „The genes for human gastrin and cholecystokinin are located on different chromosomes”. Hum. Genet. 73 (1): 77–80. DOI:10.1007/BF00292669. PMID 3011648.
• Kariya Y, Kato K, Hayashizaki Y, et al. (1987). „Expression of human gastrin gene in normal and gastrinoma tissues”. Gene 50 (1-3): 345–52. DOI:10.1016/0378-1119(86)90338-0. PMID 3034736.
• Gregory RA, Tracy HJ, Agarwal KL, Grossman MI (1969). „Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue”. Gut 10 (8): 603–8. DOI:10.1136/gut.10.8.603. PMC 1552899. PMID 5822140.
• Bentley PH, Kenner GW, Sheppard RC (1967). „Structures of human gastrins I and II”. Nature 209 (5023): 583–5. DOI:10.1038/209583b0. PMID 5921183.
• Ito R, Sato K, Helmer T, et al. (1984). „Structural analysis of the gene encoding human gastrin: the large intron contains an Alu sequence”. Proc. Natl. Acad. Sci. U.S.A. 81 (15): 4662–6. DOI:10.1073/pnas.81.15.4662. PMC 391550. PMID 6087340.
• Wiborg O, Berglund L, Boel E, et al. (1984). „Structure of a human gastrin gene”. Proc. Natl. Acad. Sci. U.S.A. 81 (4): 1067–9. DOI:10.1073/pnas.81.4.1067. PMC 344765. PMID 6322186.
• Kato K, Hayashizaki Y, Takahashi Y, et al. (1984). „Molecular cloning of the human gastrin gene”. Nucleic Acids Res. 11 (23): 8197–203. DOI:10.1093/nar/11.23.8197. PMC 326575. PMID 6324077.
• Boel E, Vuust J, Norris F, et al. (1983). „Molecular cloning of human gastrin cDNA: evidence for evolution of gastrin by gene duplication”. Proc. Natl. Acad. Sci. U.S.A. 80 (10): 2866–9. DOI:10.1073/pnas.80.10.2866. PMC 393933. PMID 6574456.
• Kato K, Himeno S, Takahashi Y, et al. (1984). „Molecular cloning of human gastrin precursor cDNA”. Gene 26 (1): 53–7. DOI:10.1016/0378-1119(83)90035-5. PMID 6689486.
• Koh TJ, Wang TC (1995). „Molecular cloning and sequencing of the murine gastrin gene”. Biochem. Biophys. Res. Commun. 216 (1): 34–41. DOI:10.1006/bbrc.1995.2588. PMID 7488110.
• Rehfeld JF, Hansen CP, Johnsen AH (1995). „Post-poly(Glu) cleavage and degradation modified by O-sulfated tyrosine: a novel post-translational processing mechanism”. EMBO J. 14 (2): 389–96. PMC 398093. PMID 7530658.
• Rehfeld JF, Johnsen AH (1994). „Identification of gastrin component I as gastrin-71. The largest possible bioactive progastrin product”. Eur. J. Biochem. 223 (3): 765–73. DOI:10.1111/j.1432-1033.1994.tb19051.x. PMID 8055952.
• Varro A, Dockray GJ (1993). „Post-translational processing of progastrin: inhibition of cleavage, phosphorylation and sulphation by brefeldin A”. Biochem. J. 295 (Pt 3): 813–9. PMC 1134634. PMID 8240296.

Vanjske veze

• Pregled Arhivirano 2017-05-19 na Wayback Machine-u