Glikogenin glukoziltransferaza (EC 2.4.1.186, glikogenin, prajmirajuća glukoziltransferaza, UDP-glukoza:glikogenin glukoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-glukoza:glikogenin alfa-D-glukoziltransferaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-glukoza + glikogenin UDP + alfa-D-glukozilglikogenin
Kratke činjenice Identifikatori, EC broj ...
Zatvori
Ovaj enzim prvo katalizuje sopstvenu glukozilaciju, normalno na Tyr-194 proteina ako je grupa slobodna. On zatim vrši glukozilaciju glukozilnih grupa dok se formira molekul sa 5--13 ostataka. Dalje produžavanje glikogenskog lanca izvodi enzim EC 2.4.1.11, glikogen (skrob) sintaza.
Krisman, C.R. and Barengo, R. (1975). „A precursor of glycogen biosynthesis: α-1,4-glucan-protein”. Eur. J. Biochem. 52: 117-123. PMID 809265. Pitcher, J., Smythe, C., Campbell, D.G. and Cohen, P. (1987). „Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin”. Eur. J. Biochem. 169: 497-502. PMID 3121316. Pitcher, J., Smythe, C. and Cohen, P. (1988). „Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle”. Eur. J. Biochem. 176: 391-395. PMID 2970965. Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). „The biogenesis of rabbit-muscle glycogen”. u: Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. str. 65-84.
Rodriguez, I.R. and Whelan, W.J. (1985). „A novel glycosyl-amino acid linkage: rabbit-muscle glycogen is covalently linked to a protein via tyrosine”. Biochem. Biophys. Res. Commun. 132: 829-836. PMID 4062948. Alonso, M.D., Lomako, J., Lomako, W.M. and Whelan, W.J. (1995). „Catalytic activities of glycogenin additional to autocatalytic self-glucosylation”. J. Biol. Chem. 270: 15315-15319. PMID 7797519. Mu, J. and Roach, P.J. (1998). „Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism”. J. Biol. Chem. 273: 34850-34856. PMID 9857012. Gibbons, B.J., Roach, P.J. and Hurley, T.D. (2002). „Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin”. J. Mol. Biol. 319: 463-177. PMID 12051921.
- Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). „The biogenesis of rabbit-muscle glycogen”. u: Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. str. 65-84.