Glikogenin glukoziltransferaza

Glikogenin glukoziltransferaza (EC 2.4.1.186, glikogenin, prajmirajuća glukoziltransferaza, UDP-glukoza:glikogenin glukoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-glukoza:glikogenin alfa-D-glukoziltransferaza.^{[1][2][3][4][5][6][7][8][9][10]} Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-alfa-D-glukoza + glikogenin ${\displaystyle \rightleftharpoons }$ UDP + alfa-D-glukozilglikogenin

Glikogenin glukoziltransferaza
Identifikatori
EC broj	2.4.1.186
CAS broj	117590-73-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Ovaj enzim prvo katalizuje sopstvenu glukozilaciju, normalno na Tyr-194 proteina ako je grupa slobodna. On zatim vrši glukozilaciju glukozilnih grupa dok se formira molekul sa 5--13 ostataka. Dalje produžavanje glikogenskog lanca izvodi enzim EC 2.4.1.11, glikogen (skrob) sintaza.

Reference

1. Krisman, C.R. and Barengo, R. (1975). „A precursor of glycogen biosynthesis: α-1,4-glucan-protein”. Eur. J. Biochem. 52: 117-123. PMID 809265.
2. Pitcher, J., Smythe, C., Campbell, D.G. and Cohen, P. (1987). „Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin”. Eur. J. Biochem. 169: 497-502. PMID 3121316.
3. Pitcher, J., Smythe, C. and Cohen, P. (1988). „Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle”. Eur. J. Biochem. 176: 391-395. PMID 2970965.
4. Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). „The biogenesis of rabbit-muscle glycogen”. u: Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. str. 65-84.
5. Rodriguez, I.R. and Whelan, W.J. (1985). „A novel glycosyl-amino acid linkage: rabbit-muscle glycogen is covalently linked to a protein via tyrosine”. Biochem. Biophys. Res. Commun. 132: 829-836. PMID 4062948.
6. Lomako, J., Lomako, W.M. and Whelan, W.J. (1988). „A self-glucosylating protein is the primer for rabbit muscle glycogen biosynthesis”. FASEB J. 2: 3097-3103. PMID 2973423.
7. Alonso, M.D., Lomako, J., Lomako, W.M. and Whelan, W.J. (1995). „Catalytic activities of glycogenin additional to autocatalytic self-glucosylation”. J. Biol. Chem. 270: 15315-15319. PMID 7797519.
8. Alonso, M.D., Lomako, J., Lomako, W.M. and Whelan, W.J. (1995). „A new look at the biogenesis of glycogen”. FASEB J. 9: 1126-1137. PMID 7672505.
9. Mu, J. and Roach, P.J. (1998). „Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism”. J. Biol. Chem. 273: 34850-34856. PMID 9857012.
10. Gibbons, B.J., Roach, P.J. and Hurley, T.D. (2002). „Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin”. J. Mol. Biol. 319: 463-177. PMID 12051921.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

• Kennedy, L.D., Kirkman, B.R., Lomako, J., Rodriguez, I.R. and Whelan, W.J. (1985). „The biogenesis of rabbit-muscle glycogen”. u: Berman, M.C. and Opie, L.A.. Membranes and Muscle. ICSU Press/IRL Press, Oxford. str. 65-84.

Spoljašnje veze

• MeSH Glycogenin+glucosyltransferase