Beta-Karbolin

β-Karbolin (9H-pirido[3,4-b]indol, norharman) je heterociklično jedinjenje koje sadrži azot. On je osnova klase jedinjenja poznatih kao β-karbolini.^[5][6]

β-Karbolin
IUPAC ime
Drugi nazivi	9H-pirido[3,4-b]indol
Identifikacija
CAS registarski broj	244-63-3 Y
PubChem[1][2]	64961
ChemSpider[3]	58486 Y
MeSH	norharman
ChEBI	109895
ChEMBL[4]	CHEMBL275224 Y
Jmol-3D slike	Slika 1
Svojstva
Molekulska formula	C11H8N2
Molarna masa	168,20 g/mol
Y (šta je ovo?)   (verifikuj) Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
Infobox references

Struktura

β-Karbolin pripada grupi [[indolni alkaloid| Beilstein = 7 | pages = 1407–11 | pmid = 22043251 | pmc = 3201054}}</ref> Različiti nivoi zasićenja su mogući u trećem prstenu, što je označeno u donjoj strukturnoj formuli obojenim dvostrukim vezama: | Gmelin = | 3DMet =

Substituted beta-carbolines (structural formula)

Primeri β-karbolina

Neki od važnijih β-karbolina su navedeni u ovoj tabeli.

Kratko ime	Crvena veza	Plava veza	R1	R6	R7	Struktura
β-Karbolin	×	×	H	H	H
Triptolin			H	H	H
Pinolin			H	OCH3	H
Harman	×		CH3	H	H
Harmin	×	×	CH3	H	OCH3
Harmalin	×		CH3	H	OCH3
Tetrahidroharmin			CH3	HH	OCH3

Reference

1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
5. Katritzky A.R., Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry. Academic Press. ISBN 0080429882.
6. Clayden Jonathan, Nick Greeves, Stuart Warren, Peter Wothers (2001). Organic chemistry. Oxford, Oxfordshire: Oxford University Press. ISBN 0-19-850346-6.

Literatura

Spoljašnje veze

Portal Hemija

• MeSH Beta-Carbolines
• TiHKAL #44
• Farzin D, Mansouri N (July 2006). „Antidepressant-like effect of harmane and other beta-carbolines in the mouse forced swim test”. Eur Neuropsychopharmacol 16 (5): 324–8. DOI:10.1016/j.euroneuro.2005.08.005. PMID 16183262.