Kalsitonin

Kalsitonin (juga dikenali sebagai tirokalsitonin) ialah suatu hormon polipeptida linear asid asid 32-amino yang dihasilkan di dalam manusia terutamanya oleh sel parafolikel (juga dikenali sebagai sel C) bagi tiroid, dan pada banyak lagi haiwan di dalam jasad ultimobrankium.^[4] Hormon ini bertindak untuk mengurangkan kalsium darah (Ca²⁺), bertentangan dengan kesan hormon paratiroid (PTH).^[5] Kalsitonin telah dijumpai pada ikan, reptilia, burung, dan mamalia. Kepentingannya pada manusia belum diasaskan dengan baik seperti kepentingannya pada haiwan lain, kerana fungsinya biasanya tidak ketara dalam pengawalaturan homeostasis kalsium normal.^[6] Hormon ini tergolong dalam keluarga protein seperti kalsitonin.

Kalsitonin
Struktur sedia ada PDB Pencarian ortolog: PDBe RCSB Senarai kod PDB 2JXZ,%%s1LS7
Pengecam
Alias	CALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
Pengecam-pengecam luaran	OMIM: 114130 MGI: 2151253 HomoloGene: 88401 GeneCards: CALCA
Kedudukan gen (Manusia) Kr. Kromosom 11[1] Jalur 11p15.2 Mula 14,966,668 bp[1] Tamat 14,972,351 bp[1]
Corak ekspresi RNA Bgee Human Mouse (ortholog) Top expressed in Ganglion akar dorsal trigeminal ganglion quadriceps femoris muscle vastus lateralis muscle cerebellar vermis Kelenjar pankreas human kidney Epithelium of choroid plexus tibialis anterior muscle right lobe of liver Top expressed in facial motor nucleus motor neuron lumbar spinal ganglion anterior horn of spinal cord lactiferous gland merih trigeminal ganglion tian tian vestibular membrane of cochlear duct More reference expression data BioGPS Rujukan lanjutan untuk data ekspresi
Ontologi gen Fungsi molekul hormone activity calcitonin receptor binding Pengikatan protein plasma identical protein binding signaling receptor binding protein-containing complex binding Komponen sel Sitoplasma Intrasel extracellular region akson terminal bouton neuronal cell body neuron projection nukleus sel Ekstrasel Proses biologi cellular response to nerve growth factor stimulus positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway negative regulation of smooth muscle contraction regulation of heart contraction monocyte chemotaxis negative regulation of blood pressure positive regulation of cytosolic calcium ion concentration cellular response to tumor necrosis factor penuaan vasodilation cellular calcium ion homeostasis response to heat negative regulation of nervous system process positive regulation of ossification activation of adenylate cyclase activity regulation of heart rate detection of temperature stimulus involved in sensory perception of pain negative regulation of ossification response to pain artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure feeding behavior inflammatory response neuropeptide signaling pathway negative regulation of transcription, DNA-templated activation of protein kinase activity embryo implantation negative regulation of bone resorption regulation of signaling receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of cytosolic calcium ion concentration leukocyte cell-cell adhesion G protein-coupled receptor internalization positive regulation of interleukin-1 alpha production response to yeast negative regulation of osteoclast differentiation cell-cell signaling antibacterial humoral response positive regulation of macrophage differentiation receptor internalization regulation of blood pressure protein phosphorylation vasculature development defense response to Gram-negative bacterium endothelial cell proliferation positive regulation of interleukin-8 production nervous system process involved in regulation of systemic arterial blood pressure negative regulation of calcium ion transport into cytosol Sistem imun semula jadi endothelial cell migration antifungal humoral response defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide amylin receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway Sumber:Amigo / QuickGO
Ortolog Spesies Manusia Mencit Entrez 796 12310 Ensembl ENSG00000110680 ENSMUSG00000030669 UniProt P06881 P70160 Q99JA0 RefSeq (mRNA) NM_001033952 NM_001033953 NM_001741 NM_001378949 NM_001378950 NM_001033954 NM_007587 NM_001289444 NM_001305616 RefSeq (protein) NP_001029125.1 NP_001029126 NP_001276373 NP_001292545 NP_031613 NP_001029126.1 NP_001276373.1 Kedudukan (UCSC) Chr 11: 14.97 – 14.97 Mb tiada data Carian PubMed [2] [3]
Wikidata
Papar/Sunting data manusia Papar/Sunting data mencit

Lihat juga

• Prokalsitonin

Rujukan

1. GRCh38: Ensembl release 89: ENSG00000110680 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Costoff A. "Sect. 5, Ch. 6: Anatomy, Structure, and Synthesis of Calcitonin (CT)". Endocrinology: hormonal control of calcium and phosphate. Kolej Perubatan Georgia. Dicapai pada 7 Ogos 2008. Cite has empty unknown parameter: |coauthors= (bantuan)
5. Boron WF, Boulpaep EL (2004). "Endocrine system chapter". Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3.
6. Costoff A. "Sect. 5, Ch. 6: Biological Actions of CT". Kolej Perubatan Georgia. Diarkibkan daripada yang asal pada 2008-07-05. Dicapai pada 7 Ogos 2008. Cite has empty unknown parameter: |coauthors= (bantuan)

Bacaan lanjut

• MacIntyre I, Alevizaki M, Bevis PJ, Zaidi M (1987). "Calcitonin and the peptides from the calcitonin gene". Clin. Orthop. Relat. Res. &na, (217): 45–55. doi:10.1097/00003086-198704000-00007. PMID 3549095.CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)
• Di Angelantonio S, Giniatullin R, Costa V; dll. (2004). "Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells". Br. J. Pharmacol. 139 (6): 1061–73. doi:10.1038/sj.bjp.0705337. PMC 1573932. PMID 12871824. Explicit use of et al. in: |author= (bantuan)CS1 maint: multiple names: authors list (link)
• Findlay DM, Sexton PM (2005). "Calcitonin". Growth Factors. 22 (4): 217–24. doi:10.1080/08977190410001728033. PMID 15621724.
• Sponholz C, Sakr Y, Reinhart K, Brunkhorst F (2007). "Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature". Critical care (London, England). 10 (5): R145. doi:10.1186/cc5067. PMC 1751067. PMID 17038199.CS1 maint: multiple names: authors list (link)
• Schneider HG, Lam QT (2007). "Procalcitonin for the clinical laboratory: a review". Pathology. 39 (4): 383–90. doi:10.1080/00313020701444564. PMID 17676478.

Pautan luar

• The Calcitonin Protein
• Calcitonin dalam Tajuk Subjek Perubatan (MeSH) di Perpustakaan Perubatan Negara AS