Bacillaenum

Bacillaenum (Anglice: bacillaene) est antibioticum ex Bacillo subtili natum, primum anno 1995 agnitum.^[1] Bacillaenum est molecula linearis cum duo nodis amidis: primus acidum α-hydroxy-carboxylicum et ω-acidum aminocarboxylicum religat, quod hexaenum coniugatum continet, et alter acidum carboxylicum religat quod hexaenum continet et acidum (ω-1)-carboxylicum, quod trienum coniugatum continet.^[2] Bacillaenum contra latum bacteriorum spectrum in spectationibus diffusionis in catino agaroso agit. Investigationes in vitro indicant hoc antibioticum synthesin proteini prokaryotici, sed non synthesin proteini eukaryotici, inhibere.

Congeries genorum ≈80-kb pksX Bacillo subtili inusitatam synthasin peptidi^? polyketidi/nonribosomalis^? hybridam (hybrid polyketide/nonribosomal peptide synthase) insignit, quae ad productionem bacillaeni antibiotici et non circumscripti adligata est.

Notae

1. P. S. Patel, S. Huang, S. Fisher, D. Pirnik, C. Aklonis, L. Dean, E. Meyers, P. Fernandes, F. Mayerl, "Bacillaene, a novel inhibitor of procaryotic protein synthesis produced by Bacillus subtilis: production, taxonomy, isolation, physico-chemical characterization and biological activity," Journal of Antibiotics (Tokyo), Sept. 1995, 48(9): 997–1003.
2. Rebecca A. Butcher, Frank C. Schroeder, Michael A. Fischbach, Paul D. Straight, Roberto Kolter, Christopher T. Walsh, Jon Clardy, "The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis," Proceedings of the National Academy of Sciences (U.S.A.), 18 Ianuarii 2007: 17234808.

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