ベンゾジアゼピン薬物乱用(ベンゾジアゼピンやくぶつらんよう、benzodiazepine drug abuse)とは、ベンゾジアゼピン系を、高揚感を得るなど娯楽目的で使用したり、医師の指示なく長期間に渡って使用し続けること[1][2]。ベンゾジアゼピン系薬物は他の一般的薬物に比べて乱用率が高い。娯楽用途でベンゾジアゼピン系を用いる場合、多くは経口投与されるが、鼻腔内投与や静脈注射されることもある。娯楽用途使用によって生じる効果はアルコール中毒に似ている[2][3]。霊長類での試験ではバルビツール酸系と類似の効果とされる[4]。
Sheehan MF, Sheehan DV, Torres A, Coppola A, Francis E(1991).“Snorting benzodiazepines”.Am J Drug Alcohol Abuse17(4): 457-68.doi:10.3109/00952999109001605.PMID1684083.
Woolverton WL, Nader MA(December 1995).“Effects of several benzodiazepines, alone and in combination with flumazenil, in rhesus monkeys trained to discriminate pentobarbital from saline”.Psychopharmacology (Berl.)122(3): 230-6.doi:10.1007/BF02246544.PMID8748392.
Griffiths RR, Lamb RJ, Sannerud CA, Ator NA, Brady JV(1991).“Self-injection of barbiturates, benzodiazepines and other sedative-anxiolytics in baboons”.Psychopharmacology (Berl.)103(2): 154-61.doi:10.1007/BF02244196.PMID1674158.
Griffiths RR, Wolf B(August 1990).“Relative abuse liability of different benzodiazepines in drug abusers”.J Clin Psychopharmacol10(4): 237-43.doi:10.1097/00004714-199008000-00002.PMID1981067.
Chatterjee, A.;Uprety, L.; Chapagain, M.; Kafle, K.(1996).“Drug abuse in Nepal: a rapid assessment study”.Bulletin on Narcotics48(1–2): 11–33.PMID9839033.
Garretty, D. J.;Wolff, K.; Hay, A. W.; Raistrick, D.(January 1997).“Benzodiazepine misuse by drug addicts”.Annals of Clinical Biochemistry34(Pt 1): 68–73.PMID9022890.
Bergman, U.;Dahl-Puustinen, M. L.(1989).“Use of prescription forgeries in a drug abuse surveillance network”.European Journal of Clinical Pharmacology36(6): 621–623.doi:10.1007/BF00637747.PMID2776820.
Jones, A. W.;Holmgren, A.; Kugelberg, F. C.(April 2007).“Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results”.Therapeutic Drug Monitor29(2): 248–260.doi:10.1097/FTD.0b013e31803d3c04.PMID17417081.
Cosbey, S. H.(December 1986).“Drugs and the impaired driver in Northern Ireland: an analytical survey”.Forensic Science International32(4): 245–58.doi:10.1016/0379-0738(86)90201-X.PMID3804143.
Lader, M. H.(1999).“Limitations on the use of benzodiazepines in anxiety and insomnia: are they justified?”.European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology9(Suppl 6): S399–405.doi:10.1016/S0924-977X(99)00051-6.PMID10622686.
Ciraulo, D. A.;Barnhill, J. G.;Greenblatt, D. J.;Shader, R. I.;Ciraulo, A. M.;Tarmey, M. F.;Molloy, M. A.;Foti, M. E.(Sep 1988).“Abuse liability and clinical pharmacokinetics of alprazolam in alcoholic men”.The Journal of Clinical Psychiatry49(9): 333–337.PMID3417618.
Ciraulo, D. A.;Sarid-Segal, O.;Knapp, C.;Ciraulo, A. M.;Greenblatt, D. J.;Shader, R. I.(Jul 1996).“Liability to alprazolam abuse in daughters of alcoholics”.The American Journal of Psychiatry153(7): 956–958.PMID8659624.
Evans, S. M.;Levin, F. R.;Fischman, M. W.(Jun 2000).“Increased sensitivity to alprazolam in females with a paternal history of alcoholism”.Psychopharmacology150(2): 150–162.doi:10.1007/s002130000421.PMID10907668.
Streeter, C. C.;Ciraulo, D. A.;Harris, G. J.;Kaufman, M. J.;Lewis, R. F.;Knapp, C. M.;Ciraulo, A. M.;Maas, L. C.et al.(May 1998).“Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism”.Psychiatry Research82(2): 69–82.doi:10.1016/S0925-4927(98)00009-2.PMID9754450.
Shimane T, Matsumoto T, Wada K(October 2012).“Prevention of overlapping prescriptions of psychotropic drugs by community pharmacists”.日本アルコール・薬物医学会雑誌47(5): 202–10.PMID23393998.