Pasou a ser coñecida tras a súa relación con John Lennon con quen casou en Xibraltar, Reino Unido en 1969.
A súa obra como artista, marcada sempre polo experimentalismo atinxiu a arte plástica e tamén á música pop. Os seus discos en colaboración con John Lennon inclúen Unfinished Music 1: Two Virgins, Unfinished Music 2: Life With The Lions, Wedding Album, Sometime In New York City: Live Jam, Double Fantasy e o póstumo Milk & Honey.
1968: Unfinished Music No.1: Two Virgins (& John Lennon)
1969: Unfinished Music No. 2: Life with the Lions (& John Lennon)
1969: Wedding Album (& John Lennon)
1969: Live Peace in Toronto 1969 (& John Lennon)
1970: Yoko Ono/Plastic Ono Band (& Plastic Ono Band)
1971: Fly
1972: Some Time in New York City (& John Lennon)
1973: Approximately Infinite Universe
1973: Feeling the Space
1973: Welcome: The Many Sides of Yoko Ono (Promo, Japan)
1974: A Story (Veröffentlicht 1997)
1980: Double Fantasy (& John Lennon)
1981: Season of Glass
1982: It’s Alright (I See Rainbows)
1984: Milk and Honey (& John Lennon)
1984: Every Man Has a Woman (Tribute-Album)
1985: Starpeace
1992: Onobox (6-CD-Box)
1992: Walking on Thin Ice
1995: Rising
1995: New York Rock (Musical)
1996: Rising Mixes
2001: Blueprint for a Sunrise
2007: Yes, I’m a Witch (Remix-Album)
2007: Open Your Box (Remix-Album)
2009: Between My Head and the Sky (& Plastic Ono Band)