Troponina C tipo 1

A troponina C, músculos esquelético lento e cardíaco ou troponina C tipo 1 (TNNC1) é unha proteína que nos humanos está codificada no xene TNNC1 do cromosoma 3.^[1] É unha das dúas isoformas da troponina C; a outra é a TNNC2. Esta isoforma intervén na regulación da contracción muscular no músculo esquelético de contracción lenta e no músculo cardíaco ao unirse a ións calcio. Cando está unida ao calcio, a contracción muscular é posible. A troponina é un complexo de tres subunidades proteicas: troponina C, T e I.

PDB 1aj4
Troponina C 1, músculo esquelético lento e cardíaca
Identificadores
Símbolo	TNNC1 ; CMD1Z; CMH13; TN-C; TNC; TNNC
Entrez	7134
OMIM	191040
RefSeq	NP_003271
UniProt	P63316
Outros datos
Locus	Cr. 3 p21.3-14.3.(52.49 – 52.49 Mb)

Interaccións

A troponina C tipo 1 interacciona con TNNI3.^{[2][3][4][5][6]}

Notas

1. "Entrez Gene: TNNC1 troponin C type 1 (slow)".
2. Ward, Douglas G; Brewer Susan M; Gallon Clare E; Gao Yuan; Levine Barry A; Trayer Ian P (May 2004). "NMR and mutagenesis studies on the phosphorylation region of human cardiac troponin I". Biochemistry (United States) 43 (19): 5772–81. ISSN 0006-2960. PMID 15134451. doi:10.1021/bi036310m.
3. Ward, Douglas G; Brewer Susan M; Calvert Melanie J; Gallon Clare E; Gao Yuan; Trayer Ian P (Apr 2004). "Characterization of the interaction between the N-terminal extension of human cardiac troponin I and troponin C". Biochemistry (United States) 43 (13): 4020–7. ISSN 0006-2960. PMID 15049709. doi:10.1021/bi036128l.
4. Ward, Douglas G; Brewer Susan M; Cornes Michael P; Trayer Ian P (Sep 2003). "A cross-linking study of the N-terminal extension of human cardiac troponin I". Biochemistry (United States) 42 (34): 10324–32. ISSN 0006-2960. PMID 12939162. doi:10.1021/bi034495r.
5. Wang, Xu; Li Monica X; Sykes Brian D (Aug 2002). "Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil". J. Biol. Chem. (United States) 277 (34): 31124–33. ISSN 0021-9258. PMID 12060657. doi:10.1074/jbc.M203896200.
6. Li, Monica X; Saude Erik J; Wang Xu; Pearlstone Joyce R; Smillie Lawrence B; Sykes Brian D (Jul 2002). "Kinetic studies of calcium and cardiac troponin I peptide binding to human cardiac troponin C using NMR spectroscopy". Eur. Biophys. J. (Germany) 31 (4): 245–56. ISSN 0175-7571. PMID 12122471. doi:10.1007/s00249-002-0227-1.

Véxase tamén

Bibliografía

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• Song WJ, Van Keuren ML, Drabkin HA; et al. (1997). "Assignment of the human slow twitch skeletal muscle/cardiac troponin C gene (TNNC1) to human chromosome 3p21.3-->3p14.3 using somatic cell hybrids.". Cytogenet. Cell Genet. 75 (1): 36–7. PMID 8995486. doi:10.1159/000134453.
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• Keane NE, Quirk PG, Gao Y; et al. (1997). "The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase--structural consequences and functional implications.". Eur. J. Biochem. 248 (2): 329–37. PMID 9346285. doi:10.1111/j.1432-1033.1997.00329.x.
• Stefancsik R, Jha PK, Sarkar S (1998). "Identification and mutagenesis of a highly conserved domain in troponin T responsible for troponin I binding: potential role for coiled coil interaction.". Proc. Natl. Acad. Sci. U.S.A. 95 (3): 957–62. PMC 18637. PMID 9448267. doi:10.1073/pnas.95.3.957.
• Vassylyev DG, Takeda S, Wakatsuki S; et al. (1998). "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 4847–52. PMC 20176. PMID 9560191. doi:10.1073/pnas.95.9.4847.
• Redwood C, Lohmann K, Bing W; et al. (2000). "Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein.". Circ. Res. 86 (11): 1146–52. PMID 10850966. doi:10.1161/01.res.86.11.1146.
• Hoffmann B, Schmidt-Traub H, Perrot A; et al. (2001). "First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy.". Hum. Mutat. 17 (6): 524. PMID 11385718. doi:10.1002/humu.1143.
• Schmidtmann A, Lohmann K, Jaquet K (2002). "The interaction of the bisphosphorylated N-terminal arm of cardiac troponin I-A 31P-NMR study.". FEBS Lett. 513 (2-3): 289–93. PMID 11904166. doi:10.1016/S0014-5793(02)02340-2.
• Lindhout DA, Li MX, Schieve D, Sykes BD (2002). "Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C.". Biochemistry 41 (23): 7267–74. PMID 12044157. doi:10.1021/bi020100c.
• Wang X, Li MX, Sykes BD (2002). "Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil.". J. Biol. Chem. 277 (34): 31124–33. PMID 12060657. doi:10.1074/jbc.M203896200.
• Li MX, Saude EJ, Wang X; et al. (2003). "Kinetic studies of calcium and cardiac troponin I peptide binding to human cardiac troponin C using NMR spectroscopy.". Eur. Biophys. J. 31 (4): 245–56. PMID 12122471. doi:10.1007/s00249-002-0227-1.

Ligazóns externas

• GeneReviews/NIH/NCBI/UW entrada sobre a cardiopatía hipertrófica familiar