A troponina C, músculo esquelético rápido ou troponina C tipo 2 (TNNC2) é unha proteína que nos humanos está codificada no xene TNNC2 do cromosoma 20.[1][2] É unha das dúas isoformas da troponina C; a outra é a TNNC1. Esta isoforma está presente nos músculos esqueléticos de contracción rápida, e únese a ións calcio, regulando a contracción muscular. Cando está unida ao calcio, a contracción muscular é posible. A troponina é un complexo de tres subunidades: troponina C, T e I.[2]
Gahlmann R, Kedes L (Aug 1990). "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene". J Biol Chem 265 (21): 12520–8. PMID 2373703.
Bibliografía
- Romero-Herrera AE, Castillo O, Lehmann H (1977). "Human skeletal muscle proteins. The primary structure of troponin C.". J. Mol. Evol. 8 (3): 251–70. PMID 978749. doi:10.1007/bf01730999.
- Tomasselli AG, Hui JO, Adams L; et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.". J. Biol. Chem. 266 (22): 14548–53. PMID 1907279.
- Gahlmann R, Wade R, Gunning P, Kedes L (1988). "Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts.". J. Mol. Biol. 201 (2): 379–91. PMID 3166492. doi:10.1016/0022-2836(88)90145-3.
- Prentice H, Kloner RA, Prigozy T; et al. (1995). "Tissue restricted gene expression assayed by direct DNA injection into cardiac and skeletal muscle.". J. Mol. Cell. Cardiol. 26 (10): 1393–401. PMID 7869399. doi:10.1006/jmcc.1994.1157.
- Tiso N, Rampoldi L, Pallavicini A; et al. (1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast.". Biochem. Biophys. Res. Commun. 230 (2): 347–50. PMID 9016781. doi:10.1006/bbrc.1996.5958.
- Townsend PJ, Yacoub MH, Barton PJ (1998). "Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis.". Ann. Hum. Genet. 61 (Pt 5): 457–9. PMID 9459007. doi:10.1046/j.1469-1809.1997.6150457.x.
- Vassylyev DG, Takeda S, Wakatsuki S; et al. (1998). "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 4847–52. PMC 20176. PMID 9560191. doi:10.1073/pnas.95.9.4847.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
