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Chemical compound From Wikipedia, the free encyclopedia
Z-FA-FMK, abbreviating for benzyloxycarbonyl-phenylalanyl-alanyl-fluoromethyl ketone, is a very potent irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain. It also selectively inhibits effector caspases 2, 3, 6, and 7 but not caspases 8 and 10.[1] This compound has been shown to block the production of IL1-α, IL1-β, and TNF-α induced by LPS in macrophages by inhibiting NF-κB pathways.
Names | |
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IUPAC name
N-[(1S)-2-[(3-Fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-,phenylmethyl ester | |
Other names
Z-Phe-Ala-Fluoromethyl Ketone | |
Identifiers | |
3D model (JSmol) |
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PubChem CID |
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UNII | |
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Properties | |
C21H23FN2O4 | |
Molar mass | 386.423 g·mol−1 |
Density | 1.207 g/cm3 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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