Vilanterol

Vilanterol is an ultra-long-acting β₂-adrenoceptor agonist which was approved in May 2013 in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of chronic obstructive pulmonary disease (COPD).^[1][2] The combination is also approved for the treatment of asthma in Canada, Europe, Japan^[3] and New Zealand.^[4]

Vilanterol

Clinical data
License data	EU EMA: by INN
Pregnancy category	AU: B3
ATC code	R03AK10 (WHO) (+fluticasone) R03AL03 (WHO) (+umeclidinium)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Identifiers
IUPAC name 4-{(1R)-2-[(6-{2-[(2,6-Dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
CAS Number	503068-34-6
PubChem CID	10184665
IUPHAR/BPS	7353
ChemSpider	8360167
UNII	028LZY775B
KEGG	D09696
ChEBI	CHEBI:75037
ChEMBL	ChEMBL1198857
CompTox Dashboard (EPA)	DTXSID80198318
ECHA InfoCard	100.217.751
Chemical and physical data
Formula	C24H33Cl2NO5
Molar mass	486.43 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1cc(c(c(c1)Cl)COCCOCCCCCCNC[C@@H](c2ccc(c(c2)CO)O)O)Cl
InChI InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1 Key:DAFYYTQWSAWIGS-DEOSSOPVSA-N

Vilanterol is available in following combinations:

• with inhaled corticosteroid fluticasone furoate—fluticasone furoate/vilanterol (trade names Breo Ellipta (U.S., NZ), Relvar Ellipta (EU, RU, JPN))
• with muscarinic antagonist umeclidinium bromide—umeclidinium bromide/vilanterol (trade name Anoro Ellipta)
• with inhaled corticosteroid fluticasone furoate and muscarinic antagonist umeclidinium bromide—fluticasone furoate/umeclidinium bromide/vilanterol (trade name Trelegy Ellipta)

See also

• Salmeterol—the long-acting β₂-adrenergic receptor agonist from which vilanterol was derived.

References

1. "FDA approves Breo Ellipta to treat chronic obstructive pulmonary disease". Food and Drug Administration. Retrieved 10 May 2013.
2. McKeage K (September 2014). "Fluticasone furoate/vilanterol: a review of its use in chronic obstructive pulmonary disease". Drugs. 74 (13): 1509–22. doi:10.1007/s40265-014-0269-6. PMID 25074268. S2CID 29379731.
3. Syed YY (March 2015). "Fluticasone furoate/vilanterol: a review of its use in patients with asthma". Drugs. 75 (4): 407–18. doi:10.1007/s40265-015-0354-5. PMID 25648266. S2CID 24563680.
4. Zealand (www.bka.co.nz), Site designed and developed by bka interactive ltd, Auckland, New (22 June 2019). "Fluticasone and vilanterol | Health Navigator NZ". Health Navigator New Zealand.{{cite web}}: CS1 maint: multiple names: authors list (link)