Umeclidinium bromide

Chemical compound From Wikipedia, the free encyclopedia

Umeclidinium bromide

Umeclidinium bromide, sold under the brand name Incruse Ellipta, is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).[3] It is also approved for this indication in combination with vilanterol (as umeclidinium bromide/vilanterol)[4][5] and also as a triple-therapy combination as fluticasone furoate/umeclidinium bromide/vilanterol.[6]

Quick Facts Clinical data, Trade names ...
Umeclidinium bromide
Thumb
Thumb
Clinical data
Trade namesIncruse Ellipta
Other namesGSK573719A
License data
Routes of
administration
Inhalation (DPI)
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding~89%[3]
MetabolismLiver (CYP2D6)
Elimination half-life11 hours
ExcretionFeces (58%) and urine (22%)
Identifiers
  • Diphenyl-[1-(2-phenylmethoxyethyl)-1-azoniabicyclo[2.2.2]octan-4-yl]methanol bromide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard100.166.375
Chemical and physical data
FormulaC29H34BrNO2
Molar mass508.500 g·mol−1
3D model (JSmol)
  • OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2.[Br-]
  • InChI=1S/C29H34NO2.BrH/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25;/h1-15,31H,16-24H2;1H/q+1;/p-1
  • Key:PEJHHXHHNGORMP-UHFFFAOYSA-M
Close

It is on the World Health Organization's List of Essential Medicines.[7] In 2020, it was the 245th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[8][9]

References

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.