Tolazoline

Tolazoline
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Intravenous
ATC code	C04AB02 (WHO) M02AX02 (WHO) QV03AB94 (WHO);
Identifiers
	IUPAC name 2-Benzyl-4,5-dihydro-1H-imidazole;
CAS Number	59-98-3 ;
PubChem CID	5504;
IUPHAR/BPS	7310;
DrugBank	DB00797 ;
ChemSpider	5303 ;
UNII	CHH9H12AQ3;
KEGG	D08614 ;
ChEBI	CHEBI:28502 ;
ChEMBL	ChEMBL770 ;
CompTox Dashboard (EPA)	DTXSID3023683 ;
ECHA InfoCard	100.000.408
Chemical and physical data
Formula	C10H12N2
Molar mass	160.220 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N\1=C(\NCC/1)Cc2ccccc2;
	InChI InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12) ; Key:JIVZKJJQOZQXQB-UHFFFAOYSA-N ;
	(verify)

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.^[1] It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). It has also been used (in conjunction with sodium nitroprusside) successfully as an antidote to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-HT_2A receptor agonist drugs such as 25I-NBOMe,^[2] DOB, and Bromodragonfly.^[3]^[4]

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It is however most commonly used in veterinary medicine, to reverse xylazine-induced sedation.^[5]^[6]

References