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Chemical compound From Wikipedia, the free encyclopedia
Dimethoxybromoamphetamine (DOB), also known as brolamfetamine (INN)[2] and bromo-DMA, is a psychedelic drug and substituted amphetamine of the phenethylamine class of compounds. DOB was first synthesized by Alexander Shulgin in 1967.[3][4] Its synthesis and effects are documented in Shulgin's book PiHKAL: A Chemical Love Story.[3]
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| Other names | DOB; 4-Bromo-2,5-dimethoxyamphetamine; Brolamfetamine; Brolamphetamine; Bromo-DMA; 2,5-Dimethoxy-4-bromo-α-methylphenethylamine; 4-Bromo-2,5-dimethoxyphenyl-isopropylamine |
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| Formula | C11H16BrNO2 |
| Molar mass | 274.158 g·mol−1 |
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| Melting point | 63–65 °C (145–149 °F) (207–208 °C hydrochloride) |
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The full name of the chemical is 2,5-dimethoxy-4-bromoamphetamine. DOB has a stereocenter and R-(−)-DOB is the eutomer. This is an important finding as it is suggestive that it is targeting different receptors relative to most other phenethylamines (e.g. MDMA) where the R-isomer serves as the distomer. The toxicity of DOB is not fully known, although high doses may cause serious vasoconstriction of the extremities. DOB is one of the most potent compounds in PiHKAL; while the active dose is similar to that of DOI, another psychedelic amphetamine, DOB has been shown to have a higher efficacy in triggering downstream effects mediated by 5-HT2 receptors,[5] making it likely to be slightly more dangerous than DOI in overdose, due to greater vasoconstrictive action. Omission of the amphetamine related α-methyl leads to 2C-B, a compound that possesses a lower affinity for the 5-HT2A receptor and is a weaker receptor agonist which results in drastically reduced vasoconstriction.[citation needed]
DOB is a serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonist or partial agonist.[6] Its psychedelic effects are mediated by its agonistic properties at the 5-HT2A receptor. Due to its selectivity, DOB is often used in scientific research when studying the 5-HT2 receptor subfamily. It is an agonist of human TAAR1.[7]
It has been suggested that DOB is a prodrug metabolized in the lungs.[3][8]
Excessively high doses of this hallucinogen may cause diffuse arterial spasm.[9] The vasospasm responded readily to intra-arterial and intravenous vasodilators, such as tolazoline.
DOB was first synthesized by Alexander Shulgin in 1967.[3] It was first described in the scientific literature in a paper by Shulgin, Claudio Naranjo, and another colleague in 1971.[4] The INN of DOB, brolamfetamine, was proposed and recommended by the World Health Organization in 1986.[10][11] It was registered with the organization as a supposed "anorexic" (appetite suppressant).[12]
Internationally, DOB is a Schedule I substance under the Convention on Psychotropic Substances and the drug is legal only for medical, industrial or scientific purposes.[13]
Listed as a Schedule 1 as it is an analogue of amphetamine.[14]
DOB is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (February 2017).[15] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[15]
Schedule I, possession of at least 10 mg is a criminal offence.[16]
DOB is a Class A drug in the United Kingdom under the Misuse of Drugs Act 1971.
DOB is a Schedule I controlled substance under federal law in the United States.[17] It was scheduled in 1973.[18]
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