SYNPO

Synaptopodin is a protein that in humans is encoded by the SYNPO gene.^[5][6][7]

SYNPO
Identifiers
Aliases	SYNPO, synaptopodin
External IDs	OMIM: 608155; MGI: 1099446; HomoloGene: 5274; GeneCards: SYNPO; OMA:SYNPO - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 150,601,080 bp[1] End 150,659,207 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 D3- E1 Start 60,727,045 bp[2] End 60,793,214 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh apex of heart Descending thoracic aorta gastrocnemius muscle Skeletal muscle tissue of rectus abdominis ascending aorta right coronary artery right auricle tendon of biceps brachii left ventricle Top expressed in ascending aorta aortic valve muscle of thigh external carotid artery tunica media of zone of aorta lumbar spinal ganglion dentate gyrus of hippocampal formation granule cell superior frontal gyrus cumulus cell ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin binding Cellular component cytoplasm perikaryon cell junction postsynaptic membrane dendritic spine plasma membrane cell projection synapse cytoskeleton membrane postsynaptic density bicellular tight junction Z discdkac nucleus actin cytoskeleton stress fiber spine apparatus Schaffer collateral - CA1 synapse glutamatergic synapse Biological process positive regulation of actin filament bundle assembly regulation of stress fiber assembly spine apparatus assembly visual learning regulation of long-term neuronal synaptic plasticity modification of dendritic spine postsynaptic modulation of chemical synaptic transmission positive regulation of postsynaptic cytosolic calcium concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11346 104027 Ensembl ENSG00000171992 ENSMUSG00000043079 UniProt Q8N3V7 Q8CC35 RefSeq (mRNA) NM_001109974 NM_001166208 NM_001166209 NM_007286 NM_001109975 NM_177340 RefSeq (protein) NP_001103444 NP_001159680 NP_001159681 NP_009217 NP_001103445 NP_796314 Location (UCSC) Chr 5: 150.6 – 150.66 Mb Chr 18: 60.73 – 60.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM]^[7]

Interactions

SYNPO has been shown to interact with MAGI1.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000171992 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043079 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mundel P, Heid HW, Mundel TM, Krüger M, Reiser J, Kriz W (Oct 1997). "Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes". The Journal of Cell Biology. 139 (1): 193–204. doi:10.1083/jcb.139.1.193. PMC 2139823. PMID 9314539.
6. Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
7. "Entrez Gene: SYNPO synaptopodin".
8. Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B (Aug 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". The Journal of Biological Chemistry. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (Sep 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B (Aug 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". The Journal of Biological Chemistry. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, Klotman PE (Sep 2004). "Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways". The Journal of Clinical Investigation. 114 (5): 643–51. doi:10.1172/JCI21004. PMC 514582. PMID 15343382.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Kremerskothen J, Plaas C, Kindler S, Frotscher M, Barnekow A (Feb 2005). "Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/alpha-actinin binding protein". Journal of Neurochemistry. 92 (3): 597–606. doi:10.1111/j.1471-4159.2004.02888.x. PMID 15659229. S2CID 1837841.
• Asanuma K, Kim K, Oh J, Giardino L, Chabanis S, Faul C, Reiser J, Mundel P (May 2005). "Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner". The Journal of Clinical Investigation. 115 (5): 1188–98. doi:10.1172/JCI23371. PMC 1070637. PMID 15841212.
• Husain M, D'Agati VD, He JC, Klotman ME, Klotman PE (Nov 2005). "HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN". AIDS. 19 (17): 1975–80. doi:10.1097/01.aids.0000191918.42110.27. PMID 16260903. S2CID 40286329.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Hirakawa M, Tsuruya K, Yotsueda H, Tokumoto M, Ikeda H, Katafuchi R, Fujimi S, Hirakata H, Iida M (Jul 2006). "Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis". Life Sciences. 79 (8): 757–63. doi:10.1016/j.lfs.2006.02.031. PMID 16564554.
• Asanuma K, Yanagida-Asanuma E, Faul C, Tomino Y, Kim K, Mundel P (May 2006). "Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling". Nature Cell Biology. 8 (5): 485–91. doi:10.1038/ncb1400. PMID 16622418. S2CID 12861229.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Garovic VD, Wagner SJ, Petrovic LM, Gray CE, Hall P, Sugimoto H, Kalluri R, Grande JP (Apr 2007). "Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia". Nephrology, Dialysis, Transplantation. 22 (4): 1136–43. doi:10.1093/ndt/gfl711. PMID 17255128.