MAGI1

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1 gene.^[5][6][7]

MAGI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WBP, 2KPK, 2KPL, 2Q9V, 2R4H, 2YSD, 2YSE, 2ZAJ, 3BPU
Identifiers
Aliases	MAGI1, AIP-3, AIP3, BAIAP1, BAP-1, BAP1, MAGI-1, Magi1d, TNRC19, WWP3, membrane associated guanylate kinase, WW and PDZ domain containing 1, MAGI-1b
External IDs	OMIM: 602625; MGI: 1203522; HomoloGene: 31257; GeneCards: MAGI1; OMA:MAGI1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.1 Start 65,353,525 bp[1] End 66,038,918 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 93,652,436 bp[2] End 94,260,898 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone sural nerve corpus callosum ganglionic eminence Achilles tendon superior frontal gyrus Cerebellum cerebellar cortex prefrontal cortex cerebellar hemisphere Top expressed in ventricular zone otic vesicle ventromedial nucleus zygote lateral hypothalamus genital tubercle ventral tegmental area saccule lumbar spinal ganglion inferior colliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular adaptor activity nucleotide binding protein C-terminus binding protein binding ATP binding alpha-actinin binding Cellular component adherens junction cell junction plasma membrane cell projection membrane cell-cell junction nucleoplasm bicellular tight junction nucleus cytoplasm Biological process neuron death cell surface receptor signaling pathway cell adhesion protein-containing complex assembly signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9223 14924 Ensembl ENSG00000282956 ENSG00000151276 ENSMUSG00000045095 UniProt Q96QZ7 Q6RHR9 RefSeq (mRNA) NM_001033057 NM_004742 NM_015520 NM_001365903 NM_001365904 NM_001365905 NM_001029850 NM_001083320 NM_001083321 NM_001286784 NM_001286785 NM_001286786 NM_001286788 NM_010367 RefSeq (protein) NP_001028229 NP_004733 NP_056335 NP_001352832 NP_001352833 NP_001352834 NP_001025021 NP_001076789 NP_001076790 NP_001273713 NP_001273714 NP_001273715 NP_001273717 NP_034497 Location (UCSC) Chr 3: 65.35 – 66.04 Mb Chr 6: 93.65 – 94.26 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell–cell contact. The product of this gene may play a role as scaffolding protein at cell–cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]

Interactions

MAGI1 has been shown to interact with:

• ACCN3,^[8]
• ATN1,^[9]
• Actinin alpha 4,^[10]
• Beta-catenin,^[11]
• Brain-specific angiogenesis inhibitor 1,^[5]
• Calcium-activated potassium channel subunit alpha-1,^[12]
• FCHSD2,^[13]
• LRP2,^[14] and
• SYNPO.^[10]