STK25

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.^[5][6][7][8]

STK25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XIK, 3W8H, 4NZW
Identifiers
Aliases	STK25, SOK1, YSK1, serine/threonine kinase 25
External IDs	OMIM: 602255; MGI: 1891699; HomoloGene: 48428; GeneCards: STK25; OMA:STK25 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,492,670 bp[1] End 241,509,730 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 D|1 47.25 cM Start 93,547,473 bp[2] End 93,586,381 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh right lobe of thyroid gland right hemisphere of cerebellum gastrocnemius muscle left lobe of thyroid gland right frontal lobe apex of heart ventricular zone anterior pituitary ganglionic eminence Top expressed in spermatocyte dentate gyrus of hippocampal formation granule cell neural layer of retina spermatid superior frontal gyrus ventricular zone genital tubercle muscle of thigh right ventricle tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein homodimerization activity metal ion binding kinase activity protein binding ATP binding protein serine/threonine kinase activity MAP kinase kinase kinase kinase activity Cellular component cytoplasm Golgi apparatus Golgi membrane extracellular exosome Biological process intrinsic apoptotic signaling pathway in response to hydrogen peroxide phosphorylation response to oxidative stress positive regulation of axonogenesis establishment of Golgi localization Golgi reassembly establishment or maintenance of cell polarity protein phosphorylation Golgi localization protein autophosphorylation response to hydrogen peroxide signal transduction positive regulation of stress-activated MAPK cascade MAPK cascade regulation of mitotic cell cycle regulation of apoptotic process neuron projection morphogenesis stress-activated protein kinase signaling cascade activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10494 59041 Ensembl ENSG00000115694 ENSMUSG00000026277 UniProt O00506 Q9Z2W1 RefSeq (mRNA) NM_001271977 NM_001271978 NM_001271979 NM_001271980 NM_001282305 NM_001282306 NM_001282307 NM_001282308 NM_006374 NM_021537 RefSeq (protein) NP_001258906 NP_001258907 NP_001258908 NP_001258909 NP_001269234 NP_001269235 NP_001269236 NP_001269237 NP_006365 NP_067512 Location (UCSC) Chr 2: 241.49 – 241.51 Mb Chr 1: 93.55 – 93.59 Mb PubMed search [3] [4]
Wikidata
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Interactions

STK25 has been shown to interact with STRN,^[9] PDCD10^[10] and MOBKL3.^[9]