NME1-NME2

NM23-LV (also known as NME1-NME2) is a human gene.^[4]

NME1-NME2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3BBB, 3BBF, 1NSK, 3BBC, 1NUE
Identifiers
Aliases	NME1-NME2, NM23-LV, NMELV, NME1-NME2 readthrough
External IDs	MGI: 3648428; HomoloGene: 39553; GeneCards: NME1-NME2; OMA:NME1-NME2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 51,153,590 bp[1] End 51,171,744 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad stromal cell of endometrium prefrontal cortex testicle appendix dorsolateral prefrontal cortex Brodmann area 9 right adrenal gland mucosa of transverse colon islet of Langerhans n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity DNA binding nucleotide binding protein histidine kinase activity DNA-binding transcription factor activity metal ion binding kinase activity protein binding ATP binding nucleoside diphosphate kinase activity protein serine/threonine kinase activity fatty acid binding intermediate filament binding enzyme binding transcription coactivator activity GDP binding G-quadruplex DNA binding Cellular component cytoplasm cytosol cell projection focal adhesion ruffle extracellular exosome nucleus cell periphery lamellipodium extracellular region secretory granule lumen ficolin-1-rich granule lumen intermediate filament mitochondrial membranes perinuclear region of cytoplasm Biological process UTP biosynthetic process peptidyl-histidine phosphorylation nucleobase-containing small molecule interconversion CTP biosynthetic process regulation of transcription, DNA-templated phosphorylation positive regulation of epithelial cell proliferation positive regulation of keratinocyte differentiation negative regulation of apoptotic process nucleotide metabolic process nucleoside diphosphate phosphorylation transcription, DNA-templated cell adhesion nucleoside triphosphate biosynthetic process integrin-mediated signaling pathway GTP biosynthetic process regulation of epidermis development positive regulation of transcription by RNA polymerase II neutrophil degranulation negative regulation of myeloid leukocyte differentiation positive regulation of neuron projection development cellular response to oxidative stress protein autophosphorylation protein complex oligomerization response to growth hormone cellular response to glucose stimulus cellular response to fatty acid adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 654364 433968 Ensembl ENSG00000011052 n/a UniProt P22392 n/a RefSeq (mRNA) NM_001018136 n/a RefSeq (protein) NP_001018147 NP_001018148 NP_001018149 NP_001185611 NP_002503 NP_001018146 n/a Location (UCSC) Chr 17: 51.15 – 51.17 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

The NME1-NME2 mRNA is a naturally occurring co-transcribed product of the neighboring NME1 and NME2 genes. The significance of this co-transcribed mRNA and the function of its predicted protein product have not yet been determined.

Alternative splicing of this gene results in different transcript variants encoding distinct isoforms, but the full-length nature of each variant has not been defined.^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000011052 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: NME1-NME2 NM23-LV".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Valentijn LJ, Koster J, Versteeg R (2006). "Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV". Genomics. 87 (4): 483–9. doi:10.1016/j.ygeno.2005.11.004. PMID 16442775.