NME2

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.^[5][6]

NME2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BBB, 3BBF, 1NSK, 3BBC, 1NUE
Identifiers
Aliases	NME2, NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF, NME/NM23 nucleoside diphosphate kinase 2
External IDs	OMIM: 156491; MGI: 97356; HomoloGene: 133879; GeneCards: NME2; OMA:NME2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 51,165,435 bp[1] End 51,171,744 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 93,840,640 bp[2] End 93,847,085 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary skin of abdomen skin of leg left coronary artery canal of the cervix mucosa of esophagus mucosa of transverse colon lactiferous gland right ovary body of pancreas Top expressed in right kidney epiblast pancreas quadriceps femoris muscle morula human kidney islet of Langerhans muscle tissue embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity DNA binding nucleotide binding protein histidine kinase activity DNA-binding transcription factor activity metal ion binding kinase activity protein binding ATP binding nucleoside diphosphate kinase activity protein serine/threonine kinase activity fatty acid binding intermediate filament binding enzyme binding transcription coactivator activity GDP binding G-quadruplex DNA binding Cellular component cytoplasm cytosol cell projection focal adhesion ruffle extracellular exosome nucleus cell periphery lamellipodium extracellular region secretory granule lumen ficolin-1-rich granule lumen intermediate filament mitochondrial membranes perinuclear region of cytoplasm Biological process UTP biosynthetic process peptidyl-histidine phosphorylation nucleobase-containing small molecule interconversion CTP biosynthetic process regulation of transcription, DNA-templated phosphorylation positive regulation of epithelial cell proliferation positive regulation of keratinocyte differentiation negative regulation of apoptotic process nucleotide metabolic process nucleoside diphosphate phosphorylation transcription, DNA-templated cell adhesion nucleoside triphosphate biosynthetic process integrin-mediated signaling pathway GTP biosynthetic process regulation of epidermis development positive regulation of transcription by RNA polymerase II neutrophil degranulation negative regulation of myeloid leukocyte differentiation positive regulation of neuron projection development cellular response to oxidative stress protein autophosphorylation protein complex oligomerization response to growth hormone cellular response to glucose stimulus cellular response to fatty acid adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4831 18103 Ensembl ENSG00000243678 ENSMUSG00000020857 UniProt P22392 Q01768 RefSeq (mRNA) NM_002512 NM_001018137 NM_001018138 NM_001018139 NM_001198682 NM_001077529 NM_008705 RefSeq (protein) NP_001018147 NP_001018148 NP_001018149 NP_001185611 NP_002503 NP_001018146 NP_001070997 NP_032731 Location (UCSC) Chr 17: 51.17 – 51.17 Mb Chr 11: 93.84 – 93.85 Mb PubMed search [3] [4]
Wikidata
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Function

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally occurring transcripts (NME1-NME2) which encode a fusion protein consisting of sequence sharing identity with each individual gene product.^[6]

Interactions

NME2 has been shown to interact with NME3^[7][8] and HERC5.^[9]