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Sicily is the largest region in Italy in terms of area, with a population of over five million and has contributed many famous names to all walks of life. Geographically, it is the largest and most populated island in the Mediterranean Sea.
This list includes notable natives of Sicily and its predecessor states, as well as those who were born elsewhere but spent a large part of their active life in Sicily. People of Sicilian heritage and descent are in a separate section of this article. The Sicilian-Americans have a specific list.
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- Pantaenus (died 200 AD), theologian, saint
- Agatha of Catania (231–251 AD), martyr and saint
- Lucy of Syracuse (283–304 AD), martyr and saint
- Saint Vitus (c. 290–c. 303 AD), martyr and saint
- Euplius (died 304 AD), martyr and saint
- Bassianus of Lodi (c. 320– c. 409), bishop and saint
- Mamilian of Palermo (died 460), bishop and saint
- Olivia of Palermo (448-463), martyr and saint
- Pope Agatho (575–681), Pope from 678 to his death, saint
- Pope Leo II (611–683), Pope from 682 to his death, saint
- Pope Sergius I (650–701), Pope from 687 to his death, saint
- Pope Stephen III (723–772), Pope from 768 to his death
- Methodios I (788/800–847), Ecumenical Patriarch of Constantinople and saint
- Leo Luke of Corleone (815–915), monk and saint
- Joseph the Hymnographer (816–886), monk and saint
- Elias of Enna (822 or 823–903), monk and saint
- Symeon of Trier (980/990–1035), monk and saint
- Filarete of Calabria (c. 1020–1070), monk and saint
- John Theristus (1049–1129), monk and saint
- Rosalia of Palermo (1130–1166), hermit and saint
- Albert of Trapani (1240–1307), friar and saint
- Agostino Novello (1240–1309), Augustinian friar, scholar and blessed
- Nicolò de' Tudeschi "Panormitanus", (1386–1445), canonist, pseudocardinal
- Pietro Geremia (1399–1452), Dominican preacher and blessed
- Eustochia Smeralda Calafato (1434–1485), Franciscan hermitess and saint
- Luigi Rabatà (1443–1490), Carmelite priest and blessed
- Benedict the Moor (1526–1589), friar and saint
- Giordano Ansaloni (1598–1634), Dominican missionary and saint
- Bernard of Corleone (1605–1667), friar and saint
- Prospero Intorcetta (1626–1696), Jesuit missionary
- Giuseppe Maria Tomasi (1649–1713), Theatine priest, cardinal and saint
- Giovanni Battista Sidotti (1668–1714), priest, missionary
- Felix of Nicosia (1715–1787), Capuchin friar and saint
- Giacomo Cusmano (1834–1888), priest and blessed
- Mariano Rampolla (1843–1913), cardinal secretary of state
- Annibale Maria di Francia (1851–1927), priest and saint
- Carolina Santocanale (1852–1923), nun and blessed
- Maria Crocifissa Curcio (1877–1957), Carmelite nun and blessed
- Gabriele Allegra (1907–1976), Franciscan missionary, translator and blessed
- Giuseppina Suriano (1915–1950), Catholic activist and blessed
- Salvatore Pappalardo (1918–2006), archbishop and cardinal
- Francesco Spoto (1924–1964), priest, missionary and blessed
- Pino Puglisi (1937–1993), priest and blessed
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- Empedocles (c. 490–430 BC), scientist and philosopher
- Acron (5th century BC), physician
- Gorgias (c. 483–375 BC), philosopher
- Hicetas (c. 400–c. 335 BC), philosopher
- Monimus (c. 399–300 BC), philosopher
- Menecrates of Syracuse (4th century BC), physician
- Euhemerus (c. 330–250 a.C.), philosopher
- Dicaearchus (c. 350–c. 285 BC), philosopher, cartographer, geographer, mathematician
- Archimedes (c. 287 – 212 BC), engineer and mathematician
- Ibn Zafar (1104–1170), philosopher and polymath
- Giovanni Aurispa (1376–1459), anthropologist
- Francesco Maurolico (1494–1575), mathematician
- Giovanni Filippo Ingrassia (1510–1580), physician, anatomist
- Giovanni Battista Hodierna (1597–1660), astronomer
- Paolo Boccone (1633–1704), botanist
- Tommaso Campailla (1668–1740), philosopher, doctor, poet
- Francesco Paolo Cantelli (1875–1966), mathematician
- Orso Mario Corbino (1876–1937), physicist
- Leonardo Ximenes (1716–1786), mathematician, engineer, astronomer, geographer
- Bernardino da Ucria (1739–1796), botanist
- Giuseppe Piazzi (1746–1826), astronomer, discovered the minor planet Ceres
- Niccolò Cacciatore (1780–1841), astronomer
- Vincenzo Tineo (1791–1856), botanist
- Gioacchino Ventura di Raulica (1792–1861), philosopher
- Filippo Parlatore (1816–1877), botanist
- Stanislao Cannizzaro (1826–1910), chemist
- Giuseppe Seguenza (1833–1889), naturalist, geologist
- Giuseppe Sergi (1841–1936), anthropologist
- Gaetano Mosca (1858–1941), political scientist
- Silvio Micali (born 1954), computer scientists and Turing award recipient
- Gaspare Mignosi (1875–1951), mathematician
- Gaetano Fichera (1922–1996), mathematician
- Giuseppe Lauricella (1867–1913), mathematician
- Giovanni Gentile (1875–1944), philosopher
- José Ingenieros (1877–1925), physician, pharmacist, philosopher
- Michele Cipolla (1880–1947), mathematician
- Mauro Picone (1885–1977), mathematician
- Giuseppe Oddo (1865–1954), chemist
- Emanuele Paternò (1847–1935), chemist
- Giuseppe Mario Bellanca (1886–1960), aviation inventor
- Giovanni Sansone (1888–1979), mathematician
- David J. Impastato (1903–1986), neuropsychiatrist
- Giuseppe Gabrielli (1903–1987), aeronautics engineer
- Michele Parrinello (born 1945), physicist
- Antonino Lo Surdo (1880–1949), physicist
- Ettore Majorana (1906–1997), physicist
- Quirino Majorana (1871–1957), physicist
- Antonino Zichichi (born 1929), physicist
- Luca Parmitano (born 1976), engineer and astronaut
- Vito Latora (born 1971), physicist
- Flavia Sparacino (born 1966)
- Napoleone Ferrara (born 1956)
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- Epicharmus of Kos (c. 524–c. 435 BC), comic poet, dramatist, philosopher
- Antiochus of Syracuse (5th century BC), historian
- Corax of Syracuse (5th century BC), rhetorician
- Sophron (5th century BC), writer of mimes
- Lysias (c. 445–c. 380 BC), logographer, jurist
- Philistus (c. 432–356 BC), historian
- Carcinus (c. 420–360 BC), dramatist
- Archestratus (4th century BC), poet
- Timaeus (c. 345–250 BC), historian
- Rhinthon (c. 323–285 BC), dramatist
- Theocritus (c. 310–250 BC), poet
- Diodorus Siculus (c. 90–30 BC), historian
- Julius Firmicus Maternus (4th century AD), writer, astrologer
- Ibn al-Qatta (1041–1121), philologist and lexicographer
- Ibn Hamdis (1056–1133), poet
- Al-Mazari (1061–1141), eminent jurist from Mazara del Vallo
- Eugenius of Palermo (c. 1130–1202), translator
- Cielo d'Alcamo (13th century), poet
- Nina Siciliana (13th century), poet
- Stefano Protonotaro da Messina (13th century), poet
- Giacomo da Lentini (1210–1260), poet
- Guido Delle Colonne (1215–1290), poet
- Antonio Beccadelli (1394–1471), poet, historian
- Pietro Ranzano (1428–1492), historian
- Lucio Marineo (1444–1533), humanist, historian
- Giovanni Luca Barberi (1452–1520), historian
- Cataldo Parisio (1455–1517), humanist
- Tommaso Fazello (1498–1570), historian
- Nicoletta Pasquale (16th century), poet
- Antonio Veneziano (1543–1593), poet
- Sebastiano Bagolino (1562–1604), poet, scholar
- Pietro Fullone (1600–1670), poet
- Filadelfo Mugnos (1607–1675), historian, genealogist, poet
- Giuseppe Artale (1632–1679), poet
- Giovanni Meli (1740–1815), poet
- Domenico Tempio (1750–1821), poet
- Michele Amari (1806–1889), historian, orientalist, politician
- Gabriele Dara (1826–1885), Arbëreshë poet, politician
- Luigi Capuana (1839–1915), writer
- Giovanni Verga (1840–1922), novelist
- Giuseppe Pitrè (1841–1916), historian
- Mario Rapisardi (1844–1912), poet
- Napoleone Colajanni (1847–1921), writer, journalist, politician
- Pietro Gori (1865–1911), journalist, poet
- Luigi Pirandello (1867–1936), dramatist, Nobel laureate
- Nino Martoglio (1870–1921), writer, dramatist
- Maria Messina (1887–1944), writer of short fiction, novelist
- Giuseppe Tomasi di Lampedusa (1896–1957), writer, poet
- Ignazio Buttitta (1899–1997), poet
- Salvatore Quasimodo (1901–1968), poet, Nobel laureate
- Ercole Patti (1903–1976), writer
- Vitaliano Brancati (1907–1954), writer
- Elio Vittorini (1908–1966), writer
- Helle Busacca (1915–1996), poet
- Gesualdo Bufalino (1920–1996), writer
- Leonardo Sciascia (1921–1989), writer, politician
- Vince Colletta (1923–1991), comic book artist, art director
- Andrea Camilleri (1925–2019), novelist
- Giuseppe Fava (1925–1984), writer and dramatist
- Mario Francese (1925–1979), journalist
- Maria Costa (1926–2016), poet
- Candido Cannavò (1930–2009) sports journalist
- Santi Visalli (born 1932), photojournalist
- Vincenzo Consolo (1933–2012), novelist
- Dacia Maraini (born 1936), novelist
- Gaetano Cipolla (born 1937), Sicilian-to-English translator, author, publisher of the journal Arba Sicula
- Emma Baeri (born 1942), feminist historian, political scientist
- Peppino Impastato (1948–1978), journalist, political activist
- Marcello Sorgi (born 1955), writer, journalist
- Lara Cardella (born 1969), novelist
- Melissa Panarello (born 1985), novelist
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- Phalaris (died 555 or 554 BC), tyrant of Akragas
- Theron (c. 535–472 BC), tyrant of Akragas
- Diocles of Syracuse (5th century BC), legislator and military leader
- Gelo (died 478 BC), tyrant of Gela and Syracuse
- Hiero I (died 467 or 466), tyrant of Gela and Syracuse
- Ducetius (died 440 BC), king of the Sicels
- Dionysius I (432 – 367 BC), tyrant of Syracuse
- Dion (408 – 354 BC), tyrant of Syracuse, friend of Plato
- Hermocrates (died 407 BC), Syracusan general
- Charondas (4th century), lawgiver
- Dionysius II (397 – 343 BC), tyrant of Syracuse
- Timoleon (411 – 337 BC), tyrant of Syracuse
- Agathocles (361 – 289 BC), tyrant of Syracuse
- Hicetas of Leontini (died 338 BC), tyrant of Leontini
- Hiero II (c. 308–c. 215 BC), tyrant of Syracuse
- Antander (4th century BC–3rd century BC), strategos
- Epicydes (3rd century BC), tyrant of Syracuse
- Lanassa (3rd century BC), queen consort of Epirus and Macedon
- Hieronymus, (231–214 BC), tyrant of Syracuse
- Euphemius (9th century AD), admiral
- al-Hasan al-Kalbi (r. 948 – 964 AD), founder of the Emirate of Sicily
- Jawhar al-Siqilli (966–992), general of the Fatimid Caliphate
- Roger I[1] (1031–1101), founder of the County of Sicily
- Felicia (1078–1102), queen consort of Hungary
- Roger II[2] (1095-1154), king of Sicily
- William I (1131–1166), king of Sicily
- William II (1155–1189), king of Sicily
- Tancred (1138–1194), king of Sicily
- William III (1186–1198), king of Sicily
- Constance I (1154–1198), queen of Sicily, Holy Roman Empress
- Frederick II[3] (1194–1250), king of Sicily, Holy Roman Emperor
- Henry VII (1211–1242), king of Sicily and Germany
- Manfred[4] (1232–1266), king of Sicily
- Constance II (1249–1302), queen consort of Aragon and Sicily
- Frederick III[5] (1272–1337), king of Sicily
- Peter II (1304–1342), king of Sicily
- Constance (1305–1344), queen consort of Jerusalem and Cyprus and Armenia
- Eleanor (1325–1375), queen consort of Aragon
- Louis (1338–1355), king of Sicily
- Frederick IV (1341–1377), king of Sicily
- Maria (1363–1401), queen of Sicily
- Costanza Chiaramonte (1377–1423), queen consort of Naples
- Ferdinand II (1810–1859), king of the Two Sicilies
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- Abu al-Qasim ibn Hammud (c. 1130), qā’id or senoir official
- Leopoldo de Gregorio, Marquess of Squillace (1699–1785), statesman
- Federico Carlo Gravina (1756–1806), admiral of Spain
- Francesco Paolo Di Blasi (1753/1755–1795), jurist, revolutionary
- Carlo Cottone (1756–1829), politician
- Ruggero Settimo (1776–1863), politician
- Giuseppe La Farina (1815–1863), politician
- Giuseppe Natoli (1815–1867), politician
- Francesco Crispi (1819–1901), politician, 11th Prime Minister of Italy
- Emanuele Notarbartolo (1834–1893), politician
- Antonio Starabba, Marquess of Rudinì (1839–1908), politician, 12th Prime Minister of Italy
- Antonino Paternò Castello, Marquess of San Giuliano (1852–1914), diplomat and Minister of Foreign Affairs
- Vittorio Emanuele Orlando (1860–1952), politician, 23rd Prime Minister of Italy
- Pietro Lanza di Scalea (1863–1938), politician
- Luigi Sturzo (1871–1959), politician
- Guido Jung (1876–1949), banker, politician
- Andrea Finocchiaro Aprile (1878–1964), politician
- Gaspare Ambrosini (1886–1986), judge, politician
- Luigi Rizzo (1887–1951), admiral
- Gaetano Martino (1900–1967), politician
- Vincent R. Impellitteri (1900–1987), politician, mayor of New York City
- Mario Scelba (1901–1991), politician
- Filippo Anfuso (1901–1963), diplomat, politician
- Ugo La Malfa (1903–1979), politician
- Giorgio La Pira (1904–1977), politician
- Giuseppe Alessi (1905–2009), politician
- Antonio Canepa (1908–1945), politician, revolutionary
- Placido Rizzotto (1914–1948), trade union leader
- Antonino Caponnetto (1920–2002), judge
- Cesare Terranova (1921–1979), judge, politician
- Rocco Chinnici (1925–1983), judge
- Pio La Torre (1927–1982), politician
- Boris Giuliano (1930–1979), policeman
- Piersanti Mattarella (1935–1980), politician
- Giovanni Falcone (1939–1992), judge
- Paolo Borsellino (1940–1992), judge
- Sergio Mattarella (born 1941), judge, politician, current president of Italy
- Antonio Martino (born 1942), politician
- Pietro Grasso (born 1945), judge, politician
- Ninni Cassarà (1947–1985), policeman
- Ignazio La Russa (born 1947), politician
- Leoluca Orlando (born 1947), politician
- Renato Schifani (born 1950), politician
- Rosario Livatino (1952–1990), judge
- Anna Finocchiaro (born 1955), politician
- Angelino Alfano (born 1970), politician
- Alfonso Bonafede (born 1976), politician
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- Antonello da Messina (1430–1479), painter
- Riccardo Quartararo (1443–1506), painter
- Girolamo Alibrandi (1470–1524), painter
- Antonello Gagini (1478–1536), sculptor
- Giacomo del Duca (1520–1604), sculptor, architect
- Tommaso Laureti (1530–1602), painter
- Natale Masuccio (1561–1619), Jesuit architect
- Mariano Smiriglio (1561–1636), architect, painter
- Mario Minniti (1577–1640), painter
- Alonzo Rodriguez (1578–1648), painter
- Antonio Barbalonga (1600–1649), painter
- Pietro Novelli (1603–1647), painter
- Giovanni Quagliata (1603–1673), painter
- Onofrio Gabrielli (1619–1706), painter
- Agostino Scilla (1629–1700), painter
- Angelo Italia (1628–1700), Jesuit architect
- Filippo Tancredi (1655–1722), painter
- Gaetano Giulio Zumbo (1656–1701), sculptor
- Filippo Juvarra (1678–1736), architect
- Rosario Gagliardi (1698–1762), architect
- Giovanni Battista Vaccarini (1702–1768), architect
- Pietro Novelli (1603–1647), painter
- Giacomo Serpotta (1656–1732), sculptor
- Olivio Sòzzi (1696–1765), painter
- Giovanni Antonio Medrano (1703–1760), architect
- Vincenzo Sinatra (1720–1765), architect
- Francesco Sabatini (1722–1797), architect
- Giuseppe Venanzio Marvuglia (1729–1814), architect
- Mariano Rossi (1731–1807), painter
- Giuseppe Velazquez (1750–1827), painter
- Giuseppe Cammarano (1766–1850), painter
- Michele Rapisardi (1822–1886), painter
- Giovan Battista Filippo Basile (1825–1891), architect
- Francesco Lojacono (1838–1915), painter
- Vitaliano Poselli (1838–1918), architect
- Vincenzo Ragusa (1841–1927), sculptor
- Ettore Ximenes (1855–1926), sculptor
- Ernesto Basile (1857–1932), architect
- Mario Rutelli (1859–1941), sculptor
- Giorgio de Chirico (1888–1978), painter
- Francisco Salamone (1897–1959), architect
- Giuseppe Migneco (1908–1997), painter
- Renato Guttuso (1912–1987), painter
- Emilio Greco (1913–1995), sculptor,
- Topazia Alliata (1913–2015), painter, art curator
- Salvatore Fiume (1915–1997), painter, sculptor, architect
- Pietro Consagra (1920–2005), sculptor
- Bruno Caruso (1927–2018), painter, illustrator, graphic designer
- Gaetano Tranchino (born 1938), painter
- Arturo Di Modica (born 1941), sculptor
- Emanuele Viscuso (born 1952), sculptor
- Manfredi Beninati (born 1970), visual artist
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- Sigismondo d'India (1582–1629), composer
- Alessandro Scarlatti (1660–1725), composer
- Emanuele d'Astorga (1680–1757), composer
- Pietro Antonio Coppola (1793–1876), composer, conductor
- Giovanni Pacini (1796–1867), composer
- Mario Aspa (1797–1868), composer
- Vincenzo Bellini (1801–1835), opera composer
- Errico Petrella (1813–1877), opera composer
- Corrado Galzio (1919–2020), musician and piano player
- Antonino Gandolfo Brancaleone (1820–1888), composer
- Achille Campisiano (1837–1908), pianist, composer
- Roberto Stagno (1840–1897), tenor
- Mario Sammarco (1868–1930), baritone
- Giuseppe Anselmi (1876–1929), tenor
- Vincent Rose (1880–1944), violinist, pianist, composer
- Ignacio Corsini (1891–1967), folklore and tango musician
- Santa Biondo (1892–1989), soprano
- Salvatore Allegra (1898–1993), composer
- Franco Ferrara (1911–1985), conductor
- Giuseppe Di Stefano (1921–2008), operatic tenor
- Rosa Balistreri (1927–1990), singer
- Roberto Pregadio (1928–2010), composer, conductor, TV personality
- Pippo Caruso (1935–2018), composer, conductor
- Tony Cucchiara (1937–2018), singer, composer
- Umberto Balsamo (born 1942), singer-songwriter
- Salvatore Adamo (born 1943), singer
- Nico dei Gabbiani (1944–2012), singer
- Aldo Stellita (1944–1998), composer, musician, member of Matia Bazar
- Franco Battiato (1945–2021), musician, filmmaker
- Gianni Bella (born 1945), singer-songwriter, composer
- Cristiano Malgioglio (born 1945), singer-songwriter, composer
- Salvatore Sciarrino (born 1947), composer
- Christian (born 1949), singer
- Frédéric François (born 1950), singer
- Giuni Russo (1951–2004), singer-songwriter
- Marcella Bella (born 1952), singer
- Vincenzo Spampinato (born 1953), singer-songwriter
- Luca Madonia (born 1957), singer-songwriter
- Giovanni Sollima (born 1962), composer, cellist
- Lucia Aliberti (born 1963), operatic soprano
- Rosario Di Bella (born 1963), singer-songwriter
- Mario Venuti (born 1963), singer-songwriter, producer
- Marcello Giordani (1963–2019), tenor
- Gerardina Trovato (born 1967), singer
- Salvatore Di Vittorio (born 1967), composer
- Francesca Alotta (born 1968), singer
- Roy Paci (born 1969), trumpeter, singer-songwriter
- Jeffrey Jey (born 1970), singer-songwriter, member of Eiffel 65
- Paolo Buonvino (born 1970), composer, conductor, music arranger
- Mario Biondi (born 1971), singer
- Filippa Giordano (born 1974), singer
- Carmen Consoli (born 1974), singer-songwriter
- Misstress Barbara (born 1975), DJ, singer-songwriter
- Antonino Fogliani (born 1976), conductor
- Desirée Rancatore (born 1977), soprano
- Vincenzo Luvineri (born 1977) rapper AKA Vinnie Paz
- Silvia Salemi (born 1978), singer-songwriter
- Marracash (born 1979), rapper
- Giusy Ferreri (born 1979), singer
- Romina Arena (born 1980), singer
- Oriana Civile (born 1980), singer and ethnomusicologist
- Cristina Scuccia (born 1988), singer
- Francesco Cafiso (born 1989), jazz saxophonist
- Giovanni Caccamo (born 1990), singer-songwriter
- Deborah Iurato (born 1991), singer
- Piero Barone (born 1993), singer, member of Il Volo
- Lorenzo Fragola (born 1995), singer
- La Bionda, composers, record producers
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- Angelo Musco (1872–1937), actor
- Ernesto Almirante (1877–1964), actor
- Febo Mari (1884–1939), actor, director
- Mimi Aguglia (1884–1970), actress
- Henry Armetta (1888–1945), actor
- Sol Polito (1892–1960), cinematographer
- Piero Carnabuci (1893–1958), actor
- Frank Capra (1897–1991), actor, director
- Rosina Anselmi (1880–1965), actress
- Michele Abruzzo (1904–1996), actor
- Rocco D'Assunta (1904–1970), actor
- Salvo Randone (1906–1991), actor
- Pino Mercanti (1911–1986), director, screenwriter
- Gino Buzzanca (1912–1985), actor
- Ignazio Balsamo (1912–1994), actor
- Saro Urzì (1913–1979), actor
- Mario Landi (1920–1992), director
- Turi Ferro (1921–2001), actor
- Adolfo Celi (1922–1986), actor
- Ciccio Ingrassia (1922–2003), actor, director
- Turi Vasile (1922–2009), producer, director
- Vittorio De Seta (1923–2011), director
- Nino Terzo (1923–2005), actor
- Carlo Sposito (1924–1984), actor
- Roberto Mauri (1924–2018), actor, director
- Carla Calò (1926–2019), actress
- Franco Franchi (1928–1992), actor
- Massimo Mollica (1929–2013), actor, theatre director
- Luigi Vannucchi (1930–1978), actor
- Franco Indovina (1932–1972), director, screenwriter
- Michele Lupo (1932–1989), director
- Pino Caruso (1934–2019), actor, author, TV personality
- Tuccio Musumeci (born 1934), actor
- Aldo Puglisi (born 1935), actor
- Robert Hundar (1935–2008), actor
- Daniela Rocca (1937–1995), actress, model
- Biagio Pelligra (born 1937), actor
- Lando Buzzanca (born 1938), actor
- Michele Gammino (born 1941), actor
- Elio Zamuto (born 1941), actor
- Luigi Maria Burruano (1945–2017), actor
- Leo Gullotta (born 1946), actor
- Beppe Cino (born 1947), director
- Carla Cassola (born 1947), actress
- Nino Frassica (born 1950), actor
- Jerry Calà (born 1951), actor, comedian
- Andrea Tidona (born 1951), actor
- Antonio Catania (born 1952), actor
- Lucia Sardo (born 1952), actress
- Frank Sivero (born 1952), actor
- Riccardo Schicchi (1953–2012), director, producer
- Tony Sperandeo (born 1953), actor
- Giuseppe Tornatore (born 1956), director
- Aurelio Grimaldi (born 1957), director
- Donatella Maiorca (born 1957), director
- Franco Maresco (born 1958), director
- Roberto Andò (born 1959), director
- Anna Kanakis (born 1962), model, actress
- Daniele Ciprì (born 1962), director
- Ninni Bruschetta (born 1962), actor, director
- Enrico Lo Verso (born 1964), actor
- Vincenzo Amato (born 1966), actor
- Luigi Lo Cascio (born 1967), actor
- Francesco Benigno (born 1967), actor
- Salvatore Termini (born 1968), actor
- Giuseppe Fiorello (born 1969), actor
- Maria Grazia Cucinotta (born 1969), actress
- Donatella Finocchiaro (born 1970), actress
- Dario Bandiera (born 1970), actor, comedian
- Ficarra e Picone (born 1971), actors, comedians
- Lorenzo Crespi (born 1971), actor
- Luca Guadagnino (born 1971), director
- Pif (born 1972), actor, director
- Paolo Briguglia (born 1974), actor
- Loredana Cannata (born 1975), actress
- Claudio Gioè (born 1975), actor
- Barbara Tabita (born 1975), actress
- Tiziana Lodato (born 1976), actress
- Daniele Gangemi (born 1980), director
- Nicole Grimaudo (born 1980), actress
- Isabella Ragonese (born 1981), actress
- Francesco Scianna (born 1982), actor
- Margareth Madè (born 1982), actress
- Valeria Bilello (born 1982), actress, model
- Tea Falco (born 1986), actress
- Chazz Palminteri (born 1952), actor
- Paolo Boi (1528–1598), chess player
- Pietro Speciale (1876–1945), fencer, gold medal in the team foil at the 1920 Antwerp Olympics
- Giovanni Canova (1880–1960), fencer (gold medal at the 1920 Summer Olympics)
- Francesco Calì (1882–1949), footballer
- Johnny Dundee (1893–1965), boxer
- Francesco Gargano (1899–1975), fencer and the first Sicilian to win a gold medal at the 1920 Antwerp Olympics
- Giovanni Corrieri (1920–2017), road bicycle racer
- Concetto Lo Bello (1924–1991), football referee
- Enzo Maiorca (1931–2016), free diver
- Guido Messina (1931–2020), road bicycle racer (gold medal with the Italian team at the 1952 Summer Olympics)
- Nino Vaccarella (born 1933), racecar driver
- Franco Scoglio (1941–2005), football manager
- Giuseppe Furino (born 1946), footballer
- Tullio Lanese (born 1947), football referee
- Pietro Anastasi (1948–2020), footballer
- Giovanni Scalzo (born 1959), fencer (gold medal in the team sabre event at the 1984 Summer Olympics)
- Salvatore Antibo (born 1962), runner
- Pasquale Marino (born 1962), footballer, football manager
- Alessandro Campagna (water polo) (born 1963), water polo player and coach
- Salvatore Schillaci (born 1964), footballer
- Maurizio Randazzo (born 1964), fencer (gold medal in the team épée events at the 1996 and 2000 Summer Olympics)
- Annarita Sidoti (1969–2015), race walker
- Andrea Lo Cicero (born 1976), rugby union player
- Valerio Vermiglio (born 1976), volleyball player
- Paolo Tiralongo (born 1977), road bicycle racer
- Giuseppe Gibilisco (born 1979), pole vaulter
- Silvia Bosurgi (born 1979), water polo player (gold medal with the Women's National Team at the 2004 Summer Olympics)
- Giuseppe Mascara (born 1979), footballer
- Giovanni Visconti[6] (born 1983), road bicycle racer
- Vincenzo Nibali (born 1984), road bicycle racer
- Tony Cairoli (born 1985), eight-time Grand Prix motocross world champion
- Luca Marin (born 1986), medley swimmer
- Damiano Caruso (born 1987), road bicycle racer
- Giorgio Avola (born 1989), fencer (gold medal at the 2012 Summer Olympics in the men's team foil event)
- Mario Balotelli (born 1990), footballer
- Daniele Garozzo (born 1992), foil fencer (gold medal in the Men's Individual Foil at the 2016 Summer Olympics)
- Marco Cecchinato (born 1992), tennis player
- Miriam Sylla (born 1995), volleyball player
- Phrygillus (5th century BC), medallist and engraver of precious stones
- Eunus (died 132 BC), leader of the slave uprising in the First Servile War
- Dina and Clarenza (13th century), heroines during the Sicilian Vespers
- Manfredi Chiaramonte (died 1391), nobleman
- Aaron Abualrabi (1400–1450), Jewish scholar, cabalist, and astrologer
- Laura Lanza, Baroness of Carini (1529–1563), noblewoman
- Juan Dominguez Palermo (c.1560–1635), conquistador
- Procopio Cutò (1651–1727), chef
- Giovanna Bonanno (1713–1789), alleged witch and poisoner
- Count Alessandro di Cagliostro (1743–1795), traveller, occultist
- Lucia Migliaccio (1770–1826), second wife of the king Ferdinand I of the Two Sicilies
- Pietro Bachi (1787–1853), professor
- Giuseppa Bolognara Calcagno (1826–1884), freedom fighter
- Joseph Whitaker (1850–1936), ornithologist, archaeologist and sportsman
- Maria Paternò Arezzo (1869–1908), noblewoman, philanthropist
- Ignazio Florio Jr. (1869–1957), entrepreneur
- Franca Florio (1873–1950), noblewoman, socialite
- Vincenzo Florio (1883–1959), entrepreneur and founder of the Targa Florio race
- Frank Lentini (1884/1889–1966), showman
- Josephine Terranova (1889–1981), accused murderer
- Fulco di Verdura (1898–1978), jeweller
- Nunzio Filogamo (1902–2002), television and radio presenter
- Bernard Castro (1904–1991), inventor
- Nicolò Carosio (1907–1984), sport journalist
- Raimondo Lanza di Trabia[7] (1915–1954), soldier, diplomat, sportsman
- Rosalia Lombardo (1918–1920), known as the Sleeping Beauty
- Renzo Barbera (1920–2002), businessman and sportsman
- Salvatore Giuliano (1922–1950), bandit
- Danilo Dolci (1924–1997), social activist, sociologist
- Enzo Sellerio (1924–2012), photographer, publisher, and collector
- Libero Grassi (1924–1991), manufacturer and antimafia activist
- Paolo Giaccone (1929–1982) professor, forensic pathologist and Mafia’s victim
- Nuccio Costa (1925–1991), television presenter
- Pino Zac (1930–1985), illustrator
- Pippo Baudo (born 1936), television presenter
- Giuseppe Coco (1936–2012), illustrator
- Lino Saputo (born 1937), businessman
- Giucas Casella (born 1949), illusionist, hypnotist
- Michele Cucuzza (born 1955), television presenter
- Domenico Dolce (born 1958), fashion designer
- Rosario Fiorello (born 1960), singer, television personality
- Pietro Scalia (born 1960), film editor
- Angelo d'Arrigo (1961–2006), aviator
- Fabrizio Corona (born 1974), photographer, actor, television personality
- Eleonora Abbagnato (born 1978), ballet dancer, model
- Eva Riccobono (born 1983), model
- Miriam Leone (born 1985), model, television personality
- La Diamond (born 1987), drag queen, winner of Drag Race Italia (season two)
- Diletta Leotta (born 1991), television personality
- Aura Eternal (born 1998), drag queen, finalist of Drag Race Italia (season two)
Europe
- Giulio Raimondo Mazzarino (1602–1661), cardinal and Chief minister of France
- Domenico Scarlatti (1685–1757), composer
- Luigi Almirante (1884–1963), actor
- Giorgio de Chirico (1888–1978), painter
- Totò (1898–1967), actor
- Julius Evola (1898–1974), political philosopher, esotericist, painter
- Giuseppe Giovanni Lanza del Vasto (1901–1981), philosopher, poet, artist
- Pietro Ingrao (1915-2015), politician
- Enrico Maria Salerno (1926–1994), actor
- Emanuele Severino (1929–2020), philosopher
- Bartolomeo Sorge (1929-2020), Jesuit
- Paolo Villaggio (1932–2017), actor
- Sophia Loren (born 1934), actress
- Bettino Craxi (1934–2000), politician, former Prime Minister of Italy
- Giuliano Amato (born 1938), politician, former Prime Minister of Italy
- Giorgio La Malfa (born 1939), politician
- Toto Cutugno (1943–2023), singer-songwriter
- Beppe Grillo (born 1948), actor and politician
- Gaetano Scirea (born 1953), footballer
- Francesco Rutelli (born 1954), Mayor of Rome
- Michele Serra (born 1954), writer and journalist
- Ignazio Marino (born 1955), Mayor of Rome
- Sergio Scariolo (born 1961), basketball coach
- Amadeus (born 1962), Tv presenter
- Antonio Albanese (born 1964), actor
- Paolo Virzì (born 1964), film director, writer, producer
- Max Gazzè (born 1967), singer-songwriter
- Gianluigi Lentini (born 1969), footballer
- Stefan Schwoch (born 1969), footballer
- Massimo Oddo (born 1976), footballer
- Giorgia Meloni (born 1977), politician
- Luca Argentero (born 1978), actor
- Sebastian Giovinco (born 1987), footballer
- Vito Mannone (born 1988), footballer
- Roberto Gagliardini (born 1994), footballer
- Nicola Cabibbo (born 1935), physicist
- Dario Argento (born 1940), film director
- Enzo Scifo (born 1966), footballer, football manager
- Lara Fabian (born 1970), singer
- Silvio Proto (born 1983), footballer
- Jean-Paul Belmondo (born 1933), actor
- Roberto Alagna (born 1963), tenor
- Jean Alesi (born 1964), Formula One driver
- Nathalie Cardone (born 1967), actress, singer
- Alexandre del Valle (born 1968), writer, professor, columnist
- Calogero (born 1971), singer
- Fabio Quartararo (born 1999), motorcycle racer
- Ralph Giordano (1923–2014), writer
- Lou Bega (born 1975), singer
- Vincenzo Grifo (born 1993), footballer
- Sébastien Buemi (1988), Formula One driver
- Gia Scala (1934–1972), actress
- Tony Iommi (born 1948), guitarist
- Ronnie O'Sullivan (born 1975), professional snooker player
- Luke Pasqualino (born 1990), actor
- Nico Mirallegro (born 1991), actor
Africa
- Edwige Fenech (born 1948), actress
- Claudio Gentile (born 1953), footballer, football manager
- Sandra Milo (born 1933), actress
- Claudia Cardinale (born 1938), actress
- Claude Bartolone (born 1951), politician, former President of the National Assembly of France
America
- Salvador Mazza (1886–1946), physician, epidemiologist
- Argentina Brunetti (1907–2005), actress
- René Favaloro (1923–2000), cardiac surgeon
- Duilio Marzio (1923–2013), actor
- Alfredo Di Stéfano (1926–2014), footballer, football manager
- Carlos Bilardo (born 1939), footballer, football manager
- Alfio Basile (born 1943), footballer, football manager
- Ricardo Bochini (born 1954), footballer
- Martín Palermo (born 1973), footballer
- Gabriel Heinze (born 1978), footballer
- Florencia Bertotti (born 1983), actress, singer
- Javier Mascherano (born 1984), footballer
- Federico Fazio (born 1987), footballer
- Leonel Vangioni (born 1987), footballer
- Yvonne De Carlo (1987–2007), actress, dancer, singer
- Joey Saputo (born 1964), businessman, sportsman
- Michael Cammalleri (born 1982), ice hockey player
- Carmelina Moscato (born 1984), soccer player
- Michael Cera (born 1994), actor, musician
Australia
- Tina Arena (born 1967), singer-songwriter
- Natalie Imbruglia (born 1975), singer, actress
- The Veronicas (born 1984), singers
- Daniel Ricciardo (born 1989), Formula One driver
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