Kottaiyannan Mudaliar: was a 14th-century chieftain who was ruling Kongu region and fought against Muslim invaders. He belongs to the lineage of Sengunthar Therinja Kaikolar regiment.
Chinna Mudaliyar: chief of Rasipuram in 16th century. He renovated many temples. He constructed a mandapam in Tiruchengode Ardhanareeswarar temple. People call him as Rasipuram Chinna Mudaliyar.
Zamindars and Mirasdars
Nagamanikam Mudaliyar: Last Zamindar of Nanjai Uthukuli, Erode district. 1,600 acre zamin estate.
S. Sivaraj Mudaliyar: Mirasdar from Tirukovilur whose family holds thousands of acre cultivatable land in that area. He won 4 times as MLA from Rishivandyam constituency.
P.S. Thuraiyappa Mudaliar: Last Mirasdar of Puthukaiputhur, Erode district. His family has hold 1300 acre cultivatable land in Gobi taluka.
A.G. Murugesa Mudaliar: Last Mirasdar of Variyankaval, Ariyalur district. His family has hold 450 acre cultivatable land in Andimadam taluk.
Social leaders, activists
S. P. Ayyaswamy Mudaliar, His house Gandhi Peak in Royapettah, Chennai hosted many INC meetings and Netaji.
C. Jambulingam Mudaliar, Indian politician and freedom-fighter who served as a civil court judge and member of the Madras Legislative Council
Muthuranga Mudaliar, Freedom-fighter from Nasarath pettai near Poonamallee in Thiruvallur District. He participated in the Quit India Movement in 1942
Sarojini Varadappan, Social worker in women welfare and empowerment, awarded Padma Shri 1971 and Padma Bhushan in 2009.
M.B. Nirmal, Social worker in consumer advocacy, afforestation programmes, and rehabilitation of convicts among others.
Tamil literature
Bharathidhasan (1891-1964) (born as Kanaga. Subburathinam Mudaliar)[9] known as Paavendhar, Puratchi Kavignar [need quotation to verify], Tamil poet, politician, social activist and teacher.
Nachimuthu Mudaliar, a philanthropist from Chennimalai. He was the founder of Chentex weavers co-operative society in which thousands of weavers benefited and he was a Padma Shree awardee. He was former president of Senguntha Mahajana Sangam.
Ekiri Sanjeevi Mudaliyar: Philanthropist and district board member,(zilla parisad member) of Chittoor district in 1937 and first president of Podaturpet town.
S. J. Ramaswamy Mudali: Textile merchant and Former MLA of Arakkonam and former MP of Sholinghur constituency.
A. Ranganatha Mudaliar: Indian politician and theosophist from Bellary, first Commissioner of the Thirumala-Tirupathi devasthanam board from 1935 to 1939.
Alarmel Valli, Classical dancer, teacher and choreographer, exponent of the Pandanallur style, of the classical dance form of Bharatanatyam, awarded Padma Shri in 1991 and Padma Bhushan in 2004.
Guruswami Mudaliar, first Indian to be appointed Professor of Therapeutics at the Madras Medical College, first Dean of Madras Medical college
A.Shanmukha Mudaliar Professor of Samskrit, Head of Department of Samskrit - Pachiyappa’s College, Chennai. Co-Founder - Kuppuswamy Sastri Research Institute. Mylapore.
M. Annamalai, Space scientist and former director of the Satish Dhawan Space Centre, Sriharikota and Senior Advisor for Space Transportations Systems at ISRO.