JWH-210

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB₁ and CB₂ receptors, with K_i values of 0.46 nM at CB₁ and 0.69 nM at CB₂. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower K_i) at CB₁ than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB₁ K_i 0.69 nM) and JWH-182 (CB₁ K_i 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB₁ K_i 1.2 nM).^[4] It was discovered by and named after John W. Huffman.

JWH-210

Legal status
Legal status	BR: Class F2 (Prohibited psychotropics)[1] CA: Schedule II DE: Anlage II[2] UK: Class B US: Schedule I Illegal in Sweden, I-N (Poland)[3]
Identifiers
IUPAC name 4-Ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone
CAS Number	824959-81-1 Y (JWH-210) 824960-02-3 (JWH-182)
PubChem CID	45270396
ChemSpider	24617616 N
UNII	R18JYO04PY
CompTox Dashboard (EPA)	DTXSID301010019
ECHA InfoCard	100.233.380
Chemical and physical data
Formula	C26H27NO
Molar mass	369.508 g·mol−1
3D model (JSmol)	Interactive image
SMILES c4cccc2c4c(CC)ccc2C(=O)c(c3)c1ccccc1n3CCCCC
InChI InChI=1S/C26H27NO/c1-3-5-10-17-27-18-24(22-13-8-9-14-25(22)27)26(28)23-16-15-19(4-2)20-11-6-7-12-21(20)23/h6-9,11-16,18H,3-5,10,17H2,1-2H3 N Key:LACIUQLUNACUKC-UHFFFAOYSA-N N
NY (what is this?)  (verify)

JWH-210 may be neurotoxic to animals when administered in high doses.^[5]

Legal status

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-210 are Schedule I Controlled Substances.^[6]

JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" synthetic cannabis products.^[7][8] The substances JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.^[9]

As of October 2015 JWH-210 is a controlled substance in China.^[10]

See also

• JWH-081
• JWH-193
• JWH-398