HOMER3

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.^[5][6][7]

HOMER3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P8V, 3CVF
Identifiers
Aliases	HOMER3, HOMER-3, VESL3, homer scaffolding protein 3, homer scaffold protein 3
External IDs	OMIM: 604800; MGI: 1347359; HomoloGene: 37972; GeneCards: HOMER3; OMA:HOMER3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,929,201 bp[1] End 18,941,261 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 70,282,827 bp[2] End 70,294,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis right hemisphere of cerebellum C1 segment spleen muscle of thigh gastrocnemius muscle inferior ganglion of vagus nerve stromal cell of endometrium ganglionic eminence right lobe of thyroid gland Top expressed in cerebellar cortex lobe of cerebellum ventricular zone yolk sac cerebellar vermis dentate gyrus of hippocampal formation granule cell neural layer of retina lip ganglionic eminence embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein C-terminus binding protein binding protein domain specific binding G protein-coupled glutamate receptor binding identical protein binding Cellular component basal part of cell cell junction postsynaptic membrane synapse postsynaptic density membrane cytoplasm cytosol plasma membrane cellular component glutamatergic synapse dendrite neuron projection Biological process G protein-coupled glutamate receptor signaling pathway protein targeting negative regulation of interleukin-2 production negative regulation of calcineurin-NFAT signaling cascade regulation of postsynaptic neurotransmitter receptor activity regulation of store-operated calcium entry Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9454 26558 Ensembl ENSG00000051128 ENSMUSG00000003573 UniProt Q9NSC5 Q99JP6 RefSeq (mRNA) NM_001145721 NM_001145722 NM_001145724 NM_004838 NM_001146153 NM_011984 RefSeq (protein) NP_001139193 NP_001139194 NP_001139196 NP_004829 NP_001139194.1 NP_001139196.1 NP_001139625 NP_036114 Location (UCSC) Chr 19: 18.93 – 18.94 Mb Chr 8: 70.28 – 70.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.^[7]

Interactions

HOMER3 has been shown to interact with TRPC1^[8] and RYR1.^[9]

See also

• HOMER1
• HOMER2

References

1. GRCh38: Ensembl release 89: ENSG00000051128 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003573 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (Feb 2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". Journal of Molecular Biology. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
6. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Oct 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. S2CID 2851554.
7. "Entrez Gene: HOMER3 homer homolog 3 (Drosophila)".
8. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576. S2CID 10552676.
9. Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.

Further reading

• Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF (Mar 1997). "Homer: a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284–8. Bibcode:1997Natur.386..284B. doi:10.1038/386284a0. PMID 9069287. S2CID 4346579.
• Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Oct 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458. S2CID 16431031.
• Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
• Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576. S2CID 10552676.
• Ishiguro K, Xavier R (Mar 2004). "Homer-3 regulates activation of serum response element in T cells via its EVH1 domain". Blood. 103 (6): 2248–56. doi:10.1182/blood-2003-08-2671. PMID 14645007.
• Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11". BMC Genetics. 6: 43. doi:10.1186/1471-2156-6-43. PMC 1208879. PMID 16098226.
• Schreiner D, Müller K, Hofer HW (Oct 2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins". FEBS Letters. 580 (22): 5295–300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624. S2CID 10267922.