HOMER2

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.^[5][6][7]

HOMER2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I7A
Identifiers
Aliases	HOMER2, ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2
External IDs	OMIM: 604799; MGI: 1347354; HomoloGene: 3560; GeneCards: HOMER2; OMA:HOMER2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.2 Start 82,836,946 bp[1] End 82,986,153 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D3 Start 81,250,229 bp[2] End 81,357,275 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas olfactory zone of nasal mucosa muscle of thigh minor salivary glands gastrocnemius muscle islet of Langerhans Skeletal muscle tissue of rectus abdominis skin of leg parotid gland skin of abdomen Top expressed in lacrimal gland parotid gland transitional epithelium of urinary bladder lateral septal nucleus substantia nigra Region I of hippocampus proper crypt of lieberkuhn of small intestine epithelium of stomach olfactory epithelium trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity protein domain specific binding synaptic receptor adaptor activity actin binding G protein-coupled glutamate receptor binding glutamate receptor binding protein heterodimerization activity Cellular component cytoplasm soma postsynaptic membrane dendrite synapse postsynaptic density membrane apical part of cell stereocilium tip cell projection stereocilium plasma membrane cell junction cytosol glutamatergic synapse neuron projection Biological process G protein-coupled glutamate receptor signaling pathway chemical homeostasis within a tissue behavioral response to cocaine regulation of G protein-coupled receptor signaling pathway hearing calcium-mediated signaling using intracellular calcium source negative regulation of interleukin-2 production negative regulation of calcineurin-NFAT signaling cascade regulation of store-operated calcium entry positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9455 26557 Ensembl ENSG00000103942 ENSMUSG00000025813 UniProt Q9NSB8 Q9QWW1 RefSeq (mRNA) NM_004839 NM_199330 NM_199331 NM_199332 NM_001164086 NM_001164087 NM_011983 NM_177029 RefSeq (protein) NP_004830 NP_955362 NP_001157558 NP_001157559 NP_036113 Location (UCSC) Chr 15: 82.84 – 82.99 Mb Chr 7: 81.25 – 81.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.^[7]

Interactions

HOMER2 has been shown to interact with RYR1.^[8]

See also

• HOMER1
• HOMER3

References

1. GRCh38: Ensembl release 89: ENSG00000103942 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025813 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
6. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Dec 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi:10.1016/S0896-6273(00)80588-7. PMID 9808458.
7. "Entrez Gene: HOMER2 homer homolog 2 (Drosophila)".
8. Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. 277 (47). United States: 44722–30. doi:10.1074/jbc.M207675200. ISSN 0021-9258. PMID 12223488.

Further reading

• Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". J. Mol. Biol. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
• Feng W, Tu J, Yang T, et al. (2003). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
• Kim JT, Park SH, Kim SK, et al. (2003). "Potential role of Homer-2a on cutaneous vascular anomaly". J. Korean Med. Sci. 17 (5): 636–40. doi:10.3346/jkms.2002.17.5.636. PMC 3054924. PMID 12378015.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T (2003). "Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons". Mol. Cell. Neurosci. 22 (2): 188–201. doi:10.1016/S1044-7431(03)00037-X. PMID 12676529. S2CID 38323844.
• Rong R, Ahn JY, Huang H, et al. (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310. S2CID 807407.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ishibashi T, Ogawa S, Hashiguchi Y, et al. (2005). "A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems". J. Biochem. 137 (5): 617–23. doi:10.1093/jb/mvi074. PMID 15944415.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Dahl JP, Kampman KM, Oslin DW, et al. (2006). "Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population". Psychiatr. Genet. 15 (4): 277–83. doi:10.1097/00041444-200512000-00010. PMID 16314758. S2CID 24128233.